Contact:

612-624-4155

matthew.moscou@usda.gov

Education:

 

Grasses and biotrophic pathogens

My group studies the interaction of grasses and biotrophic pathogens, with a focus on the cereal-rust interaction. Our research areas span genetics, bioinformatics, molecular biology, and evolutionary biology. Our long-term goal is to develop durable disease resistance to improve food security.

• Publications

  • (Clicking on the reprint icon will take you to the publication reprint.)
  • A barley MLA receptor is targeted by a specialized non-ribosomal peptide effector of the necrotrophic spot blotch fungus to induce disease susceptibility-(Peer Reviewed Journal)
    
    
  • A single NLR gene confers resistance to leaf and stripe rust in wheat -(Peer Reviewed Journal)
    Sharma, D., Avni, R., Gutierrez-Gonzalez, J., Kumar, R., Sela, H., Prusty, M.R., Shatil-Cohen, A., Molnar, I., Holusova, K., Said, M., Dolezel, J., Millet, E., Khazan-Kost, S., Landau, U., Bethke, G., Sharon, O., Ezrati, S., Ronen, M., Maatuk, O., Eilam, T., Manisterski, J., Ben-Yehuda, P., Anikster, Y., Matny, O., Steffenson, B.J., Mascher, M., Brabham, H.J., Moscou, M.J., Liang, Y., Yu, G., Wulff, B., Muehlbauer, G., Minz-Dub, A., Sharon, A. 2024. A single NLR gene confers resistance to leaf and stripe rust in wheat. Nature Communications. https://doi.org/10.1038/s41467-024-54068-6.
    
  • Colocalization of genetic regions that confer resistance/susceptibility against Puccinia species and association with Pyrenophora teres loci within the barley genome -(Peer Reviewed Journal)
    Clare, S.J., Novakazi, F., Hayes, P.M., Moscou, M.J., Brueggeman, R.S. 2024. Colocalization of genetic regions that confer resistance/susceptibility against Puccinia species and association with Pyrenophora teres loci within the barley genome. Frontiers in Agronomy. 6. https://doi.org/10.3389/fagro.2024.1451281.
    
  • VRS5 (HvTB1) binds to the promoter of tillering and floral homeotic genes to regulate their expression -(Pre-print Publication)
    Winkelmolen, T., Colleoni, P., Moscou, M.J., Hoseinzadeh, P., Oldach, K., Schmidt, R., Immink, R., Van Esse, G.W. 2024. VRS5 (HvTB1) binds to the promoter of tillering and floral homeotic genes to regulate their expression. bioRxiv. https://doi.org/10.1101/2024.08.22.609225.
    
  • Molecular mimicry of a pathogen virulence target by a plant immune receptor -(Pre-print Publication)
    Gomez De La Cruz, D., Zdrzalek, R., Banfield, M.J., Talbot, N.J., Moscou, M.J. 2024. Molecular mimicry of a pathogen virulence target by a plant immune receptor. bioRxiv. https://doi.org/10.1101/2024.07.26.605320.
    
  • Discovery of functional NLRs using high expression level, high-throughput transformation, and large-scale phenotyping -(Pre-print Publication)
    Brabham, H.J., Hernandez-Pinzon, I., Yanagihara, C., Ishikawa, N., Komori, T., Matny, O.N., Hubbard, A., Witek, K., Numazawa, H., Green, P., Dreiseitl, A., Takemori, N., Komari, T., Freedman, R.P., Steffenson, B., Van Esse, P., Moscou, M.J. 2024. Discovery of functional NLRs using high expression level, high-throughput transformation, and large-scale phenotyping. bioRxiv. https://doi.org/10.1101/2024.06.25.599845.
    
  • Barley MLA3 recognizes the host-specificity determinant PWL2 from Magnaporthe oryzae -(Peer Reviewed Journal)
    Brabham, H.J., Gomez De La Cruz, D., Were, V., Shimizu, M., Saitoh, H., Hernandez-Pinzon, I., Green, P., Lorang, J., Fujisaki, K., Sato, K., Molnar, I., Simkova, H., Dolezel, J., Russell, J., Taylor, J., Smoker, M., Gupta, Y., Wolpert, T., Talbot, N.J., Terauchi, R., Moscou, M.J. 2023. Barley MLA3 recognizes the host-specificity determinant PWL2 from Magnaporthe oryzae. The Plant Cell. 36(2):447-470. https://doi.org/10.1093/plcell/koad266.
    
  • Rapid discovery of functional NLRs using the signature of high expression and high-throughput screening-(Abstract Only)
    Brabham, H.J., Hernandez-Pinzon, I., Yanagihara, C., Ishikawa, N., Komori, T., Matny, O.N., Hubbard, A., Witek, K., Numazawa, H., Green, P., Takemori, N., Komari, T., Freedman, R.P., Steffenson, B.J., Van Esse, P., Moscou, M.J. 2023. Rapid discovery of functional NLRs using the signature of high expression and high-throughput screening [abstract]. Plant and Animal Genome Conference.
    
  • Barley MLA3 recognizes the host-specificity determinant PWL2 from rice blast (M. oryzae) -(Pre-print Publication)
    Brabham, H.J., Gomez De La Cruz, D., Were, V., Shimizu, M., Saitoh, H., Hernandez-Pinzon, I., Green, P., Lorang, J., Fujisaki, K., Sato, K., Molnar, I., Simkova, H., Dolezel, J., Russell, J., Taylor, J., Smoker, M., Gupta, Y., Wolpert, T., Talbot, N.J., Terauchi, R., Moscou, M.J. 2022. Barley MLA3 recognizes the host-specificity determinant PWL2 from rice blast (M. oryzae). bioRxiv. https://doi.org/10.1101/2022.10.21.512921.
    

• Projects

  Surveillance, Pathogen Biology, and Host Resistance of Cereal Rusts In-House Appropriated (D)   Accession Number:441854

  Wheat Stem Rust Gap Analysis and Laboratory/Field Research Project Interagency Reimbursable Agreement (I)   Accession Number:446930

  Multi-modal Prediction and Cross-scale Monitoring of Wheat Rust Disease at the Field Level Non-Assistance Cooperative Agreement (S)   Accession Number:446297

  Multi-Level Remote Sensing for High-Throughput Phenotyping of Stem Rust Disease Non-Assistance Cooperative Agreement (S)   Accession Number:438407

  Genomic of Host and Host-Pathogen Interaction in Cereal Rust Fungi Non-Assistance Cooperative Agreement (S)   Accession Number:440567

  Wheat Disease Early Warning Advisory System (DEWAS) Trust Fund Cooperative Agreement (T)   Accession Number:443991

• ARS News Articles

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