Research Project: Genomics, Nutrition, and Health

Location: Jean Mayer Human Nutrition Research Center On Aging

Publications (Clicking on the reprint icon will take you to the publication reprint.)

PhyteByte: Identification of foods containing compounds with specific pharmacological properties - (Peer Reviewed Journal)
Westerman, K., Harrington, S.M., Ordovas, J.M., Parnell, L.D. 2020. PhyteByte: Identification of foods containing compounds with specific pharmacological properties. BMC Bioinformatics. https://doi.org/10.1186/s12859-020-03582-7.

Metabolomic links between sugar-sweetened beverage intake and obesity - (Peer Reviewed Journal)
Zhou, B., Ichikawa, R., Parnell, L.D., Noel, S.E., Zhang, X., Bhupathiraju, S., Smith, C., Tucker, K.L., Ordovas, J.M., Lai, C. 2020. Metabolomic links between sugar-sweetened beverage intake and obesity. Journal of Obesity. https://doi.org/10.1155/2020/7154738.

Salivary AMY1 copy number variation modifies age-related type 2 diabetes risk - (Peer Reviewed Journal)
Liu, Y., Smith, C.E., Parnell, L.D., Lee, Y., An, P., Straka, R.J., Tiwari, H.K., Wood, A.C., Kabagame, E.K., Hopkins, P., Province, M., Arnett, D.K., Tucker, K., Ordovas, J.M., Lai, C. 2020. Salivary AMY1 copy number variation modifies age-related type 2 diabetes risk. Clinical Chemistry. 66(5):718-726. https://doi.org/10.1093/clinchem/hvaa072.

Mediterranean diet adherence modulates anthropometric measures by TCF7L2 genotypes among Puerto Rican adults - (Peer Reviewed Journal)
Sotos-Prieto, M., Smith, C.E., Lai, C., Tucker, K.L., Ordovas, J.M., Mattei, J. 2019. Mediterranean diet adherence modulates anthropometric measures by TCF7L2 genotypes among Puerto Rican adults. Journal of Nutrition. 150(1):167-175. https://doi.org/10.1093/jn/nxz210.

Long-term dietary adherence and changes in dietary intake in coronary patients after intervention with a Mediterranean diet or a low-fat diet: the CORDIOPREV randomized trial - (Peer Reviewed Journal)
Quintana-Navarro, G.M., Alcala-Diaz, J.F., Lopez-Moreno, J., Perez-Corral, I., Leon-Acuna, A., Torres-Pena, J.D., Rangel-Zuniga, O.A., Arenas De Larriva, A.P., Corina, A., Camargo, A., Yubero-Serrano, E.M., Rodriguez-Cantalejo, F., Garcia-Rios, A., Luque, R.M., Ordovas, J.M., Perez-Martinez, P., Lopez-Miranda, J., Delgado-Lista, J. 2019. Long-term dietary adherence and changes in dietary intake in coronary patients after intervention with a Mediterranean diet or a low-fat diet: the CORDIOPREV randomized trial. European Journal of Nutrition. https://doi.org/10.1007/s00394-019-02059-5.

DNA methylation modules associate with incident cardiovascular disease and cumulative risk factor exposure - (Peer Reviewed Journal)
Westerman, K., Sebastiani, P., Jacques, P., Liu, S., Demeo, D., Ordovas, J.M. 2019. DNA methylation modules associate with incident cardiovascular disease and cumulative risk factor exposure. Journal of Clinical Epigenetics. 11:142. https://doi.org/10.1186/s13148-019-0705-2.

A genome-wide association study identifies blood disorder-related variants influencing hemoglobin A1c with implications for glycemic status in U.S. Hispanics/Latinos - (Peer Reviewed Journal)
Moon, J., Louie, T., Jain, D., Sofer, T., Schurmann, C., Below, J.E., Lai, C., Aviles-Santa, M., Talavera, G.A., Smith, C.E., Petty, L.E., Bottinger, E.P., Chen, Y.I., Taylor, K.D., Daviglus, M.L., Cai, J., Wang, T., Tucker, K.L., Ordovas, J.M., Hanis, C.L., Loos, R.J., Schneiderman, N., Rotter, J.I., Kaplan, R.C., Qi, Q. 2019. A genome-wide association study identifies blood disorder-related variants influencing hemoglobin A1c with implications for glycemic status in U.S. Hispanics/Latinos. Diabetes Care. 42(8). https://doi.org/10.2337/dc19-0168.

Ultra-processed food consumption and incident frailty: a prospective cohort study of older adults - (Peer Reviewed Journal)
Sandoval-Insausti, H., Blanco-Rojo, R., Graciani, A., Lopez-Garcia, E., Moreno-Franco, B., Laclaustra, M., Donat-Vargas, C., Ordovas, J.M., Rodriguez-Artalejo, F., Guallar-Castillon, P. 2019. Ultra-processed food consumption and incident frailty: a prospective cohort study of older adults. The Journals of Gerontology: Medical Sciences. https://doi.org/10.1093/gerona/glz140.

Gene lifestyle interactions with relation to obesity, cardiometabolic, and cardiovascular traits among South Asians - (Review Article)
Ahmad, S., Fatima, S.S., Rukh, G., Smith, C.E. 2019. Gene lifestyle interactions with relation to obesity, cardiometabolic, and cardiovascular traits among South Asians. Frontiers in Endocrinology. https://doi.org/10.3389/fendo.2019.00221.

Development of a genetic score to predict an increase in HDL cholesterol concentration after a dietary intervention in adults with metabolic syndrome - (Peer Reviewed Journal)
Guevara-Cruz, M., Medina-Vera, I., Flores-Lopez, A., Aguilar-Lopez, M., Smith, C.E., Parnell, L.D., Lee, Y., Lai, C., Tovar, A.R., Ordovas, J.M., Torres, N. 2019. Development of a genetic score to predict an increase in HDL cholesterol concentration after a dietary intervention in adults with metabolic syndrome. Journal of Nutrition. https://doi.org/10.1093/jn/nxz060.

Dairy intake and body composition and cardiometabolic traits among adults: Mendelian randomization analysis of 182041 individuals from 18 studies: Mendelian randomization of dairy consumption working group - (Peer Reviewed Journal)
Huang, T., Sun, D., Heianza, Y., Bergholdt, H.K., Gao, M., Fang, Z., Ding, M., Frazier-Wood, A.C., North, K.E., Marouli, E., Graff, M., Smith, C.E., Varbo, A., Lemaitre, R.N., Corella, D., Wang, C.A., Tjonneland, A., Overvad, K., Sorensen, T.I., Feitosa, M.F., Wojczynski, M.K., Kahonen, M., Mikkila, V., Bartz, T.M., Psaty, B.M., Siscovick, D.S., Danning, R.D., Dedoussis, G., Pedersen, O., Hansen, T., Havulinna, A.S., Mannisto, S., Rotter, J.I., Sares-Jaske, L., Allison, M.A., Rich, S.S., Sorli, J.V., Coltell, O., Pennell, C.E., Eastwood, P., Ridker, P.M., Viikari, J., Raitakari, O., Lehtimaki, T., Helminen, M., Wang, Y., Deloukas, P., Knekt, P., Kanerva, N., Kilpelainen, T.O., Province, M.A., Mozaffarian, D., Chasman, D.I., Nordestgaard, B.G., Ellervik, C., Qi, L. 2019. Dairy intake and body composition and cardiometabolic traits among adults: Mendelian randomization analysis of 182041 individuals from 18 studies: Mendelian randomization of dairy consumption working group. Clinical Chemistry. 65(6):751-760. https://doi.org/10.1373/clinchem.2018.300335.

An exome-wide sequencing study of the GOLDN cohort reveals novel associations of coding variants and fasting plasma lipids - (Peer Reviewed Journal)
Geng, X., Irvin, M.R., Hidalgo, B., Aslibekyan, S., Srinivasasainagendra, V., An, P., Frazier-Wood, A.C., Tiwari, H.K., Dave, T., Ryan, K., Ordovas, J.M., Straka, R.J., Feitosa, M.F., Hopkins, P.N., Borecki, I., Province, M.A., Mitchell, B.D., Arnett, D.K., Zhi, D. 2019. An exome-wide sequencing study of the GOLDN cohort reveals novel associations of coding variants and fasting plasma lipids. Frontiers in Genetics. 10:158. https://doi.org/10.3389/fgene.2019.00158.

Genome-Wide Association Study (GWAS) on bilirubin concentrations in subjects with metabolic syndrome: sex-specific GWAS analysis and gene-diet interactions in a Mediterranean population - (Peer Reviewed Journal)
Coltell, O., Arsenio, E.M., Sorli, J.V., Barragan, R., Fernandez-Carrion, R., Portoles, O., Ortega-Azorin, C., Martinez-Lacruz, R., Gonzalez, J.I., Zonon-Moreno, V., Gimenez-Alba, I., Fito, M., Ros, E., Ordovas, J.M., Corella, D. 2019. Genome-Wide Association Study (GWAS) on bilirubin concentrations in subjects with metabolic syndrome: sex-specific GWAS analysis and gene-diet interactions in a Mediterranean population. Nutrients. 11(1):90. https://doi.org/10.3390/nu11010090.

A guide to applying the sex-gender perspective to nutritional genomics - (Review Article)
Corella, D., Coltell, O., Portoles, O., Sotos-Prieto, M., Fernandez-Carrion, R., Ramirez-Sabio, J.B., Zanon-Moreno, V., Mattei, J., Sorli, J.V., Ordovas, J.M. 2018. A guide to applying the sex-gender perspective to nutritional genomics. Nutrients. 11(1):4. https://doi.org/10.3390/nu11010004.

CLOCK gene polymorphisms and quality of aging in a cohort of nonagenarians - the MUGELLO study - (Peer Reviewed Journal)
Pagliai, G., Sofi, F., Dinu, M., Sticchi, E., Vannetti, F., Molino Lova, R., Ordovas, J.M., Gori, A.M., Marcucci, R., Giusti, B., Macchi, C. 2019. CLOCK gene polymorphisms and quality of aging in a cohort of nonagenarians - the MUGELLO study. Scientific Reports. 9(1):1472. https://doi.org/10.1038/s41598-018-37992-8.

Changes in health status predict changes in alcohol consumption in older adults: the Seniors-ENRICA cohort - (Peer Reviewed Journal)
Ortola, R., Garcia-Esquinas, E., Soler-Vila, H., Ordovas, J.M., Lopez-Garcia, E., Rodriguez-Artalejo, F. 2018. Changes in health status predict changes in alcohol consumption in older adults: the Seniors-ENRICA cohort. Journal of Epidemiology and Community Health. 73(2):123-129. https://doi.org/10.1136/jech-2018-211104.

Bitter, sweet, salty, sour and umami taste perception decreases with age: sex-specific analysis, modulation by genetic variants and taste-preference associations in 18 to 80 year-old subjects - (Peer Reviewed Journal)
Barragan, R., Coltell, O., Portoles, O., Asensio, E.M., Sorli, J.V., Ortega-Azorin, C., Gonzalez, J.I., Saiz, C., Fernandez-Carrion, R., Ordovas, J.M., Corella, D. 2018. Bitter, sweet, salty, sour and umami taste perception decreases with age: sex-specific analysis, modulation by genetic variants and taste-preference associations in 18 to 80 year-old subjects. Nutrients. 10(10):1539. https://doi.org/10.3390/nu10101539.

Association of sleep duration and quality with subclinical atherosclerosis - (Peer Reviewed Journal)
Dominguez, F., Fuster, V., Fernandez-Alvira, J.M., Fernandez-Friera, L., Lopez-Melgar, B., Blanco-Rojo, R., Fernandez-Ortiz, A., Garcia-Pavia, P., Sanz, J., Mendiguren, J.M., Ibanez, B., Bueno, H., Lara-Pezzi, E., Ordovas, J.M. 2019. Association of sleep duration and quality with subclinical atherosclerosis. Journal of the American College of Cardiology. 73(2):134-144. https://doi.org/10.1016/j.jacc.2018.10.060.

Cross-sectional associations of objectively-measured sleep characteristics with obesity and type 2 diabetes in the PREDIMED-Plus trial - (Peer Reviewed Journal)
Rosique-Esteban, N., Papandreou, C., Romagera, D., Warnberg, J., Corella, D., Martinez-Gonzalez, M.A., Diaz-Lopez, A., Estruch, R., Vioque, J., Aros, F., Garcia-Rios, A., Bueno-Cavanillas, A., Vidal, J., Serra-Majem, L., Sibai, A.A., Tinahones, F.J., Martinez, J.A., Ordovas, J.M., Tur, J.A., Torrego Ellacuria, M., Sanllorente, A., Pinto, X., Buil-Cosiales, P., Fernandez-Carrion, R., Castaner, O., Bullo, M., Ruiz-Canela, M., Garcia-De La Hera, M., Perez-Farinos, N., Baron-Lopez, F.J., Colom, A., Abete, I., Ros, E., Salas-Salvado, J. 2018. Cross-sectional associations of objectively-measured sleep characteristics with obesity and type 2 diabetes in the PREDIMED-Plus trial. Sleep. 41(12). https://doi.org/10.1093/sleep/zsy190.

Alpha cell function interacts with diet to modulate prediabetes and type 2 diabetes - (Peer Reviewed Journal)
Roncero-Ramos, I., Jimenez-Lucena, R., Alcala-Diaz, J.F., Vals-Delgado, C., Arenas-Larriva, A.P., Rangel-Zuniga, O.A., Leon-Acuna, A., Malagon, M.M., Delgado-Lista, J., Perez-Martinez, P., Ordovas, J.M., Camargo, A., Lopez-Miranda, J. 2018. Alpha cell function interacts with diet to modulate prediabetes and type 2 diabetes. Journal of Nutritional Biochemistry. 62:247-256. https://doi.org/10.1016/j.jnutbio.2018.08.012.

Curcumin supplementation increases survival and lifespan in Drosophila under heat stress conditions - (Peer Reviewed Journal)
Chen, Y., Liu, X., Jiang, C., Liu, L., Ordovas, J.M., Lai, C., Shen, L. 2018. Curcumin supplementation increases survival and lifespan in Drosophila under heat stress conditions. Biofactors. 44(6):577-587. https://doi.org/10.1002/biof.1454.

Low intake of vitamin E accelerates cellular aging in patients with established cardiovascular disease: the CORDIOPREV study - (Peer Reviewed Journal)
Corina, A., Rangel-Zuniga, O.A., Jimenez-Lucena, R., Alcala-Diaz, J.F., Quintana-Navarro, G., Yubero-Serrano, E.M., Lopez-Moreno, J., Delgado-Lista, J., Tinahones, F., Ordovas, J.M., Lopez-Miranda, J., Perez-Martinez, P. 2018. Low intake of vitamin E accelerates cellular aging in patients with established cardiovascular disease: the CORDIOPREV study. The Journals of Gerontology: Medical Sciences. https://doi.org/10.1093/gerona/gly195.

Dietary epicatechin improves survival and skeletal muscle function in aged mice - (Peer Reviewed Journal)
Si, H., Wang, X., Zhang, L., Parnell, L.D., Admed, B., Leroith, T., Ansah, T., Zhang, L., Ordovas, J.M., Liu, D., Lai, C. 2018. Dietary epicatechin improves survival and skeletal muscle function in aged mice. Journal of Federation of American Societies for Experimental Biology. https://doi.org/10.1096/fj.201800554RR.

Long-term consumption of a Mediterranean diet improves postprandial lipemia in patients with type 2 diabetes: the Cordioprev randomized trial - (Peer Reviewed Journal)
Gomez-Marin, B., Gomez-Delgado, F., Lopez-Moreno, J., Alcala-Diaz, J.F., Jimenez-Lucena, R., Torres-Pena, J.D., Garcia-Rios, A., Ortiz-Morales, A.M., Yubero-Serrano, E.M., Malagon, M., Lai, C., Delgado-Lista, J., Ordovas, J.M., Lopez-Miranda, J., Perez-Martinez, P. 2018. Long-term consumption of a Mediterranean diet improves postprandial lipemia in patients with type 2 diabetes: the Cordioprev randomized trial. American Journal of Clinical Nutrition. 108:963-970. https://doi.org/10.1093/ajcn/nqy144.

Fermented dairy products, diet quality, and cardio-metabolic profile of a Mediterranean cohort at high cardiovascular risk - (Peer Reviewed Journal)
Menz-Sanchez, G., Babio, N., Martinez-Gonzalez, M.A., Corella, D., Schroder, H., Vioque, J., Romaguera, D., Martinez, J.A., Lopez-Miranda, J., Estruch, R., Warnberg, J., Bueno-Cavanillas, A., Serra-Majem, L., Tur, J.A., Aros, F., Tinahones, F.J., Sanchez, V.M., Lapetra, J., Pinto, X., Vidal, J.C., Vasquez, C., Ordovas, J.M., Delgado-Rodriguez, M., Matia-Martin, P., Basora, J.F., Buil-Cosiales, P., Fernandez-Carrion, R., Fito, M., Salas-Salvado, J. 2018. Fermented dairy products, diet quality, and cardio-metabolic profile of a Mediterranean cohort at high cardiovascular risk. Nutrition, Metabolism and Cardiovascular Diseases. 28(10):1002-1011. https://doi.org/10.1016/j.numecd.2018.05.006.

Circulating miRNAs as predictive biomarkers of type 2 diabetes mellitus development in coronary heart disease patients from the CORDIOPREV study - (Peer Reviewed Journal)
Jimenez-Lucena, R., Rangel-Zuniga, O.A., Alcala-Diaz, J.F., Lopez-Moreno, J., Roncero-Ramos, I., Molina-Abril, H., Yubero-Serrano, E.M., Caballero-Villaraso, J., Delgado-Lista, J., Pastor-Castano, J., Ordovas, J.M., Perez-Martinez, P., Camargo, A., Lopez-Miranda, J. 2018. Circulating miRNAs as predictive biomarkers of type 2 diabetes mellitus development in coronary heart disease patients from the CORDIOPREV study. Molecular Therapy - Nucleic Acids. 12:146-157. https://doi.org/10.1016/j.omtn.2018.05.002.

Genome-wide association meta-analysis of circulating odd-numbered chain saturated fatty acids: results from the CHARGE Consortium - (Peer Reviewed Journal)
De Oliveira Otto, M.C., Lemaitre, R.N., Sun, Q., King, I., Wu, J.H., Manichaikul, A., Rich, S., Tsai, M.Y., Chen, Y., Fornage, M., Weihua, G., Aslibekyan, S., Irvin, M.R., Kabagambe, E.K., Arnett, D.K., Jensen, M.K., McKnight, B., Psaty, B.M., Steffen, L.M., Smith, C.E., Riserus, U., Lind, L., Hu, F., Rimm, E., Siscovick, D.S., Mozaffarian, D. 2018. Genome-wide association meta-analysis of circulating odd-numbered chain saturated fatty acids results from the CHARGE Consortium. PLoS One. 13(5):e0196951. https://doi.org/10.1371/journal.pone.0196951.

Epigenomics and metabolomics reveal the mechanism of the APOA2-saturated fat intake interaction affecting obesity. - (Peer Reviewed Journal)
Lai, C., Smith, C.E., Parnell, L.D., Lee, Y., Corella, D., Hopkins, P., Hidalgo, B.A., Aslibekyan, S., Province, M.A., Absher, D.M., Arnett, D.K., Tucker, K.L., Ordovas, J.M. 2018. Epigenomics and metabolomics reveal the mechanism of the APOA2-saturated fat intake interaction affecting obesity. American Journal of Clinical Nutrition. 108:188-200.

Postprandial endotoxemia may influence the development of type 2 diabetes mellitus: from the CORDIOPREV study - (Peer Reviewed Journal)
Camargo, A., Jimenez-Lucena, R., Alcala-Diaz, J.F., Rangel-Zuniga, O.A., Garcia-Carpintero, S., Lopez-Moreno, J., Blanco-Rojo, R., Delgado-Lista, J., Perez-Martinez, P., Van Ommen, B., Malagon, M.M., Ordovas, J.M., Lopez-Miranda, J. 2018. Postprandial endotoxemia may influence the development of type 2 diabetes mellitus: from the CORDIOPREV study. Clinical Nutrition. 38(2):529-538. https://doi.org/10.1016/j.clnu.2018.03.016.

New diet trials and cardiovascular risk - (Review Article)
Garcia-Rios, A., Ordovas, J.M., Lopez-Miranda, J., Perez-Martinez, P. 2018. New diet trials and cardiovascular risk. Current Opinion in Cardiology. 33(4):423-428. https://doi.org/10.1097/HCO.0000000000000523.

Weight gain prevention buffers the impact of CETP rs3764261 on high density lipoprotein cholesterol in young adulthood: the Study of Novel Approaches to Weight Gain Prevention (SNAP) - (Peer Reviewed Journal)
McCaffery, J.M., Ordovas, J.M., Huggins, G.S., Lai, C., Espeland, M.A., Tate, D.F., Wing, R.R. 2018. Weight gain prevention buffers the impact of CETP rs3764261 on high density lipoprotein cholesterol in young adulthood: the Study of Novel Approaches to Weight Gain Prevention (SNAP). Nutrition Metabolism and Cardiovascular Disease. 28(8):816-821. https://doi.org/10.1016/j.numecd.2018.02.018.

Childhood BMI and adult type 2 diabetes, coronary artery diseases, chronic kidney disease, and cardiometabolic traits: a Mendelian randomization analysis - (Peer Reviewed Journal)
Geng, T., Smith, C.E., Li, C., Haung, T. 2018. Childhood BMI and adult type 2 diabetes, coronary artery diseases, chronic kidney disease, and cardiometabolic traits: a Mendelian randomization analysis. Diabetes Care. 41:1089-1096. https://doi.org/10.2337/dc17-2141.

Transethnic evaluation identifies low-frequency loci associated with 25-hydroxyvitamin D concentrations - (Peer Reviewed Journal)
Hong, J., Hatchell, K.E., Bradfield, J.P., Bjonnes, A., Chesi, A., Lai, C., Langefeld, C.D., Lu, L., Lu, Y., Lutsey, P.L., Musani, S.K., Nalls, M.A., Robinson-Cohen, C., Roizen, J.D., Saxena, R., Tucker, K.L., Ziegler, J.T., Arking, D.E., Bis, J.C., Boerwinkle, E., Bottinger, E.P., Bowden, D.W., Gilsanz, V., Houston, D.K., Kalkwarf, H.J., Kelly, A., Lappe, J.M., Liu, Y., Michos, E.D., Oberfield, S.E., Palmer, N.D., Rotter, J.I., Sapkota, B., Shepherd, J.A., Wilson, J.G., Basu, S., De Boer, I.H., Divers, J., Freedman, B.I., Grant, S.F., Hakanarson, H., Harris, T.B., Kestenbaum, B.R., Kritchevsky, S.B., Loos, R.J., Norris, J.M., Norwood, A.F., Ordovas, J.M., Pankow, J.S., Psaty, B.M., Sanghera, D.K., Wagenknecht, L.E., Zemel, B.S., Meigs, J., Dupius, J., Florez, J.C., Wang, T.J., Liu, C., Engelman, C.D., Billings, L.K. 2018. Transethnic evaluation identifies low-frequency loci associated with 25-hydroxyvitamin D concentrations. Journal of Clinical Endocrinology and Metabolism. 103(4):1380-1392. https://doi.org/10.1210/jc.2017-01802.

Advances in understanding the molecular basis of the Mediterranean diet effect - (Review Article)
Corella, D., Coltell, O., Macian, F., Ordovas, J.M. 2018. Advances in understanding the molecular basis of the Mediterranean diet effect. Annual Review of Food Science & Technology. 9:227-249. https://doi.org/10.1146/annurev-food-032217-020802.

Endotoxemia is modulated by quantity and quality of dietary fat in older adults - (Peer Reviewed Journal)
Lopez-Moreno, J., Garcia-Carpintero, S., Gomez-Delgado, F., Jimenez-Lucena, R., Vals-Delgado, C., Alcala-Diaz, J.F., Roncero-Ramos, I., Rangel-Zuniga, O.A., Yubero-Serrano, E.M., Malagon, M.M., Ordovas, J.M., Perez-Martinez, P., Lopez-Miranda, J., Camargo, A. 2017. Endotoxemia is modulated by quantity and quality of dietary fat in older adults. Experimental Gerontology. 109:119-125. https://doi.org/10.1016/j.exger.2017.11.006.

Dairy consumption and body mass index among adults: Mendelian randomization analysis of 184802 individuals from 25 studies - (Peer Reviewed Journal)
Huang, T., Ding, M., Bergholdt, H.K., Wang, T., Heianza, Y., Sun, D., Frazier-Wood, A.C., Aslibekyan, S., North, K.E., Voortman, T., Graff, M., Smith, C., Lai, C., Varbo, A., Lemaitre, R.N., De Jonge, M.A., Fumeron, F., Corella, D., Wang, C.A., Tjønneland, A., Overvad, K., Sørensen, T.I., Feitosa, M.F., Wojczynski, M.K., Kähönen, M., Renström, F., Psaty, B.M., Siscovick, D.S., Barroso, I., Johansson, I., Hernandez, D., Ferrucci, L., Bandinelli, S., Linneberg, A., Zillikens, M., Sandholt, C., Pederson, O., Hansen, T., Schulz, C.A., Sonestedt, E., Orho-Melander, M., Chen, T., Rotter, J.I., Allison, M.A., Rich, S.S., Sorli, J.V., Coltell, O., Pennell, C.E., Eastwood, P., Hofman, A., Uitterlinden, A.G., Van Rooij, F.J., Chu, A.Y., Rose, L.M., Ridker, P.M., Viikari, J., Raitakari, O., Lehtimäki, T., Mikkilä, V., Willet, W.C., Wang, Y., Tucker, K.L., Ordovas, J.M., Kilpeläinen, T.O., Province, M.A., Franks, P.W., Arnett, D.K., Tanaka, T., Toft, U., Ericson, U., Franco, O.H., Mazaffarian, D., Hu, F.B., Chasman, D.I., Nordestgaard, B.G., Ellervik, C., Qi, L. 2018. Dairy consumption and body mass index among adults: Mendelian randomization analysis of 184802 individuals from 25 studies. Clinical Chemistry. 64(1):183-191. https://doi.org/10.1373/clinchem.2017.280701.

Environmental and epigenetic regulation of postprandial lipemia - (Peer Reviewed Journal)
Lai, C., Ordovas, J.M., Parnell, L.D. 2018. Environmental and epigenetic regulation of postprandial lipemia. Current Opinion in Lipidology. 29(1):30-35.

Mediterranean Diet adherence and genetic background roles within a web-based nutritional intervention: The Food4Me Study - (Peer Reviewed Journal)
San-Cristobal, R., Navas-Carretero, S., Livingstone, K.M., Celis-Morales, C., Macready, A.L., Fallaize, R., O'Donovan, C.B., Lambrinou, C.P., Moschonis, G., Marsaux, C.F., Manios, Y., Miroslaw, J., Hannelore, D., Gibney, E.R., Brennan, L., Drevon, C.A., Gundersen, T.E., Gibney, M., Saris, W.H., Lovegrove, J.A., Grimaldi, K., Parnell, L.D., Bouwman, J., Van Ommen, B., Mathers, J.C., Martinez, J. 2017. Mediterranean Diet adherence and genetic background roles within a web-based nutritional intervention: The Food4Me Study. Nutrients. https://doi.org/10.3390/nu9101107.

Sex differences in blood HDL-c, the total cholesterol/HDL-c ratio, and palmitoleic acid are not associated with variants in common candidate genes - (Peer Reviewed Journal)
Klingel, S.L., Roke, K., Hidalgo, B., Aslibekyan, S., Straka, R.J., An, P., Province, M.A., Hopkins, P.N., Arnett, D.K., Ordovas, J.M., Lai, C., Mutch, D.M. 2017. Sex differences in blood HDL-c, the total cholesterol/HDL-c ratio, and palmitoleic acid are not associated with variants in common candidate genes. Lipids. 52(12):969-980. https://doi.org/10.1007/s11745-017-4307-5.

Dietary fat modulation of hepatic lipase variant -514 C/T for lipids: a crossover randomized dietary intervention trial in Caribbean Hispanics - (Peer Reviewed Journal)
Smith, C.E., Van Rompay, M.I., Mattei, J., Garcia, J.F., Garcia-Bailo, B., Lichtenstein, A.H., Tucker, K.L., Ordovas, J.M. 2017. Dietary fat modulation of hepatic lipase variant -514 C/T for lipids: a crossover randomized dietary intervention trial in Caribbean Hispanics. Physiological Genomics. 49(10):592-600. https://doi.org/10.1152/physiolgenomics.00036.2017.

Genome-wide interactions with dairy intake for body mass index in adults of European descent - (Peer Reviewed Journal)
Smith, C.E., Follis, J.L., Dashti, H., Tanaka, T., Graff, M., Fretts, A.M., Kilpelainen, T., Wojczynski, M., Richardson, K., Nalls, M., Schulz, C.N., Liu, Y., Frazier-Wood, A., Van Eekelen, E., Wang, C., De Vries, P.S., Mikkila, V., Rohde, R., Psaty, B.M., Hansen, T., Feitosa, M.F., Lai, C., Houston, D.K., Ferrucci, L., Ericson, U., Wang, Z., De Mutsert, R., Oddy, W.H., De Jonge, E.A., Seppala, I., Justice, A.E., Lemaitre, R.N., Sorensen, T.I., Province, M.A., Parnell, L.D., Garcia, M.E., Bandinelli, S., Orho-Melander, M., Rich, S.S., Rosendaal, F.R., Pennell, C.E., Kiefte-Dejong, J.C., Kahonen, M., Young, K.L., Pederesen, O., Aslibekyan, S., Rotter, J.I., Mook-Kanamori, D.O., Zillikens, M.C., Raitakari, O.T., North, K.E., Overvad, K., Arnett, D.K., Hofman, A., Lehtimaki, T., Tjonneland, A., Uitterlinden, A.G., Rivadeneira, F., Franco, O.H., German, J., Siscovick, D.S., Cupples, L.A., Ordovas, J.M. 2017. Genome-wide interactions with dairy intake for body mass index in adults of European descent. Molecular Nutrition and Food Research. https://doi.org/10.1002/mnfr.201700347.

Utilizing nutritional genomics to tailor diets for the prevention of cardiovascular disease: a guide for upcoming studies and implementations - (Review Article)
Corella, D., Coltell, O., Mattingley, G., Sorli, J.V., Ordovas, J.M. 2017. Utilizing nutritional genomics to tailor diets for the prevention of cardiovascular disease: a guide for upcoming studies and implementations. Expert Review of Molecular Diagnostics. 17(5):495-513. https://doi.org/10.1080/14737159.2017.1311208.

Dairy consumption, systolic blood pressure, and risk of hypertension: Mendelian randomization study - (Peer Reviewed Journal)
Ding, M., Huang, T., Bergholdt, H.K., Frazier Wood, A.C., Aslibekyan, S., North, K.E., Voortman, T., Graff, M., Smith, C.E., Lai, C., Varbo, A., Lemaitre, R.N., De Jonge, E.A., Fumeron, F., Corella, D., Wang, C.A., Tjonneland, A., Overvad, K., Sorensen, T.I., Feitosa, M.F., Wojczynski, M.K., Kahonen, M., Ahmad, S., Trndytom, F., Psaty, B.M., Siscovick, D.S., Barroso, I., Johansson, I., Hernandez, D.G., Ferrucci, L., Bandinelli, S., Linneberg, A., Sandholt, C.H., Pedersen, O., Hansen, T., Schulz, C., Sonestedt, E., Orho-Melander, M., Chen, T., Rotter, J.I., Allison, M.A., Rich, S.S., Sorli, J.V., Coltell, O., Pennell, C.E., Eastwood, P., Hofman, A., Uitterlinden, A.G., Zillikens, M., Van Rooij, F.J., Chu, A.Y., Rose, L.M., Ridker, P.M., Viikari, J., Raitakara, O., Lehtimaki, T., Mikkila, V., Willett, W.C., Wang, Y., Tucker, K.L., Ordovas, J.M., Kilpelainen, T.O., Province, M.A., Franks, P.W., Arnett, D.K., Tanaka, T., Toft, U., Ericson, U., Franco, O.H., Mozaffarian, D., Hu, F.B., Chasman, D.I., Nordestgaard, B.G., Ellervik, C., Qi, L. 2017. Dairy consumption, systolic blood pressure, and risk of hypertension: Mendelian randomization study. British Medical Journal. doi: 10.1136/bmj.j1000.

Beneficial effect of CETP gene polymorphism in combination with a Mediterranean diet influencing lipid metabolism in metabolic syndrome patients: CORDIOPREV study - (Peer Reviewed Journal)
Garcia-Rios, A., Alcala-Diaz, J.F., Gomez-Delgado, F., Delgado-Lista, J., Marin, C., Leon-Acuna, A., Camargo, A., Rodriguez-Cantalego, F., Blanco-Rojo, R., Quintana-Navarro, G., Ordovas, J.M., Perez-Jimenez, F., Lopez-Mirando, J., Perez-Martinez, P. 2016. Beneficial effect of CETP gene polymorphism in combination with a Mediterranean diet influencing lipid metabolism in metabolic syndrome patients: CORDIOPREV study. Clinical Nutrition. doi: 10.1016/j.clnu.2016.12.011.

Genome-wide expression profiling in muscle and subcutaneous fat of lambs in response to the intake of concentrate supplemented with vitamin E - (Peer Reviewed Journal)
Gonzalea-Calvo, L., Dervishi, E., Joy, M., Sarto, P., Martin-Hernandez, R., Serrano, M., Ordovas, J.M., Calvo, J. 2017. Genome-wide expression profiling in muscle and subcutaneous fat of lambs in response to the intake of concentrate supplemented with vitamin E. BMC Genomics. doi: 10.1186/s12864-016-3405-8.

Ordovas-Oxidized LDL is associated with metabolic syndrome traits independently of central obesity and insulin resistance - (Peer Reviewed Journal)
Hurtado-Roca, Y., Bueno, H., Fernandez-Ortiz, A., Ordovas, J., Ibanez, B., Fuster, V., Rodriquez-Artalejo, F., Laclaustra, M. 2017. Ordovas-Oxidized LDL is associated with metabolic syndrome traits independently of central obesity and insulin resistance. Diabetes. doi: 10.2337/db16-0933.

Polymorphism of the transcription factor 7-like 2 Gene (TCF7L2) interacts with obesity on type-2 diabetes in the PREDIMED Study emphasizing the heterogeneity of genetic variants in type-2 diabetes risk prediction: time for... - (Peer Reviewed Journal)
Corella, D., Coltell, O., Sorli, J.V., Estruch, R., Quiles, L., Martínez-González, M.Á., Salas-Salvado, J., Castaner, O., Arós, F., Ortega-Calvo, M., Serra-Majem, L., Gomez-Gracia, E., Portoles, O., Fiol, M., Espino, J., Basora, J., Fito, M., Ros, E., Ordovas, J.M. 2016. Polymorphism of the transcription factor 7-like 2 Gene (TCF7L2) interacts with obesity on type-2 diabetes in the PREDIMED Study emphasizing the heterogeneity of genetic variants in type-2 diabetes risk prediction: time for obesity-specific genetic risk scores. Nutrients. 8(12):793. https://doi.org/10.3390/nu8120793.

Epigenome-wide association study of triglyceride postprandial responses to high-fat dietary challenge in the Genetics of Lipid Lowering Drugs and Diet Network study - (Peer Reviewed Journal)
Lai, C., Wojczynski, M.K., Parnell, L.D., Hidalgo, B., Irvin, M.R., Aslibekyan, S., Province, M.A., Devin, A., Arnett, D.K., Ordovas, J. 2016. Epigenome-wide association study of triglyceride postprandial responses to high-fat dietary challenge in the Genetics of Lipid Lowering Drugs and Diet Network study. Journal of Lipid Research. 57:2200-2207.

Heritable DNA methylation in CD4+ cells among complex families displays genetic and non-genetic effects - (Peer Reviewed Journal)
Day, K., Waite, L.L., Alonso, A., Irvin, M.R., Zhi, D., Thibeault, K.S., Aslibekyan, S., Hidalgo, B., Borecki, I., Ordovas, J.M., Arnett, D.K., Tiwari, H.K., Absher, D.M. 2016. Heritable DNA methylation in CD4+ cells among complex families displays genetic and non-genetic effects. PLoS One. doi: 10.1371/journal.pone.0165488.

Higher chylomicron remnants and LDL particle numbers associate with CD36 SNPs and DNA methylation sites that reduce CD36 - (Peer Reviewed Journal)
Love-Gregory, L., Kraja, A.T., Allum, F., Aslibekyan, S., Hedman, A.K., Duan, Y., Borecki, I.B., Arnett, D.K., Mccarthy, M.I., Deloukas, P., Ordovas, J.M., Hopkins, P.N., Grundberg, E., Abumrad, N.A. 2016. Higher chylomicron remnants and LDL particle numbers associate with CD36 SNPs and DNA methylation sites that reduce CD36. Journal of Lipid Research. doi: 10.1194/jlr.P065250.

Telomerase RNA Component (TERC) genetic variants interact with the mediterranean diet modifying the inflammatory status and its relationship with aging: CORDIOPREV study - (Peer Reviewed Journal)
Gomez-Delgado, F., Delgado-Lista, J., Lopez-Moreno, J., Rangel-Zuñiga, O., Alcala-Diaz, J., Leon Acuña, A., Baba, A.C., Yubero-Serrano, E., Torres Peña, J., Camargo, A., Garcia-Rios, A., Cabellero, J., Castaño, J., Ordovas, J.M., Lopez-Miranda, J., Perez-Martinez, P. 2016. Telomerase RNA Component (TERC) genetic variants interact with the mediterranean diet modifying the inflammatory status and its relationship with aging: CORDIOPREV study. Journal of Gerontology Medical Science. doi: 10.1093/gerona/glw194.

Identification and validation of seven new loci showing differential DNA methylation related to serum lipid profile: an epigenome-wide approach. The REGICOR study - (Peer Reviewed Journal)
Sayols-Baixeras, S., Subirana, I., Lluis-Ganella, C., Civeira, F., Roquer, J., Do, A., Absher, D., Cenarro, A., Munoz, D., Soriano-Tarraga, C., Jimenez-Conde, J., Ordovas, J.M., Senti, M., Aslibekyan, S., Marrugat, J., Arnett, D.K., Elosua, R. 2016. Identification and validation of seven new loci showing differential DNA methylation related to serum lipid profile: an epigenome-wide approach. The REGICOR study. Human Molecular Genetics. 25(20):4556-4565. doi: 10.1093/hmg/ddw285.

MicroRNAs and drinking: association between the pre-miR-27a rs895819 polymorphism and alcohol consumption in a Mediterranean population - (Peer Reviewed Journal)
Barragan, R., Coltell, O., Asensio, E.M., Frances, F., Sorli, J.V., Estruch, R., Salas-Huetos, A., Ordovas, J.M., Corella, D. 2016. MicroRNAs and drinking: association between the pre-miR-27a rs895819 polymorphism and alcohol consumption in a Mediterranean population. International Journal of Molecular Sciences. doi: 10.3390/ijms17081338.

Lunch eating predicts weight-loss effectiveness in carriers of the common allele at PERILIPIN1: the ONTIME (Obesity, Nutrigenetics, Timing, Mediterranean) study - (Peer Reviewed Journal)
Garaulet, M., Vera, B., Bonnet-Rubio, G., Gómez-Abellán, P., Lee, Y., Ordovas, J.M. 2016. Lunch eating predicts weight-loss effectiveness in carriers of the common allele at PERILIPIN1: the ONTIME (Obesity, Nutrigenetics, Timing, Mediterranean) study. American Journal of Clinical Nutrition. doi: 10.3945/ajcn.116.134528.

Genetic admixture and body composition in Puerto Rican adults from the Boston Puerto Rican osteoporosis study - (Peer Reviewed Journal)
Noel, S.E., Arevalo, S., Smith, C.E., Lai, C., Dawson-Hughes, B., Ordovas, J.M., Tucker, K.T. 2016. Genetic admixture and body composition in Puerto Rican adults from the Boston Puerto Rican Osteoporosis Study. Journal of Bone and Mineral Research. doi: 10.1007/s00774-016-0775-6.

TNFA gene variants related to the inflammatory status and its association with cellular aging: From the CORDIOPREV study - (Peer Reviewed Journal)
Rangel Zúñiga, O., Corina, A., Lucena-Porras, B., Cruz-Teno, C., Gómez-Delgado, F., Jiménez-Lucena, R., Alcalá Díaz, J., Haro Mariscal, C., Yubero-Serrano, E., Delgado-Lista, J., López Moreno, J., Rodriguez-Cantealejo, F., Carmargo, A., Tinahones, F., Ordovas, J.M., López Miranda, J., Pérez Martínez, P. 2016. TNFA gene variants related to the inflammatory status and its association with cellular aging: From the CORDIOPREV study. Experimental Gerontology. 83:56–62.

A dysregulation of glucose metabolism control is associated with carotid atherosclerosis in patients with coronary heart disease (CORDIOPREV-DIAB study) - (Peer Reviewed Journal)
Yubero-Serrano, E.M., Delgado-Lista, J., Alcala-Diaz, J.F., Garcia-Rios, A., Perez-Caballero, A.I., Blanco-Rojo, R., Gomez-Delgado, F., Marin, C., Tinahones, F., Caballero, J., Ordovas, J.M., Van Ommen, B., Perez-Jimenez, F., Perez-Martinez, P., Lopez-Miranda, J. 2016. A dysregulation of glucose metabolism control is associated with carotid atherosclerosis in patients with coronary heart disease (CORDIOPREV-DIAB study). Atherosclerosis. doi: 10.1016/j.atherosclerosis.2016.07.903.

Supplementation with major royal jelly proteins increases lifespan, feeding and fecundity in Drosophila - (Peer Reviewed Journal)
Xin, X., Chen, Y., Chen, D., Xiao, F., Parnell, L.D., Zhao, J., Liu, L., Ordovas, J.M., Lai, C., Shen, L. 2016. Supplementation with major royal jelly proteins increases lifespan, feeding and fecundity in Drosophila. Journal of Agricultural and Food Chemistry. 64(29):5803–5812. doi: 10.1021/acs.jafc.6b00514.

Using genetic technologies to reduce, rather than widen, health disparities - (Review Article)
Smith, C.E., Fuillerton, S.M., Dookeran, K.A., Hampel, H., Tin, A., Maruthur, N.M., Schisler, J.C., Henderson, J.A., Tucker, K.L., Ordovas, J.M. 2016. Using genetic technologies to reduce, rather than widen, health disparities. Health Affairs. 35(8):1367-1373.

Effect of personalized nutrition on health-related behavior change: evidence from the Food4Me randomized controlled trial - (Peer Reviewed Journal)
Celis-Morales, C., Livingstone, K.M., O'Donovan, C.B., Woolhead, C., Forster, H., Walsh, M.C., Marsaux, C.F., Macready, A.L., Fallaize, R., Tsirigoti, L., Lambrinou, C.P., Efstathopoulou, E., Moschonis, G., Navas-Carretero, S., Can-Cristobal, R., Kolossa, S., Hallmann, J., Godlewska, M., Surwilla, A., Traczyk, I., Drevon, C.A., Bouwman, J., Grimaldi, K., Parnell, L.D., Manios, Y., Daniel, H., Martinez, J., Lovegrove, J.A., Gibney, E.R., Brennan, L., Saris, W.H., Gibney, M., Mathers, J.C. 2016. Effect of personalized nutrition on health-related behavior change: evidence from the Food4Me randomized controlled trial. International Journal of Epidemiology. doi: 10.1093/ije/dyw186.

Assessment of postprandial triglycerides in clinical practice: validation in a general population and coronary heart disease patients - (Peer Reviewed Journal)
Perez-Martinez, P., Alcala-Diaz, J.F., Kabagambe, E.K., Garcia-Rios, A., Tsai, M.Y., Delgado-Lista, J., Kolobou, G., Straka, R.J., Gomez-Delgado, F., Hopkins, P.N., Marin, C., Borecki, I.B., Yubero-Serrano, E.M., Hixson, J.E., Camargo, A., Province, M.A., Lopez-Moreno, J., Rodriguez-Cantalejo, F., Tinahones, F.J., Mikhailidis, D., Perez-Jimenez, F., Arnett, D.K., Ordovas, J.M., Lopez-Miranda, J. 2016. Assessment of postprandial triglycerides in clinical practice: validation in a general population and coronary heart disease patients. Journal of Clinical Lipidology. doi: 10.1016/j.jacl.2016.05.009.

Association between a social-business eating pattern and early asymptomatic atherosclerosis - (Peer Reviewed Journal)
Penalvo, J.L., Fernandez-Friera, L.L., Lopez-Melgar, B., Uzhova, I., Oliva, B., Fernandez-Alvira, J.M., Laclaustra, M., Pocock, S., Mocoroa, A., Mendiguren, J.M., Sanz, G., Guallar, E., Bansilal, S., Vedanthan, R., Jimenez-Borreguero, L.J., Ibanez, B., Ordovas, J.M., Fernandez-Ortiz, A., Bueno, H., Fuster, V. 2016. Association between a social-business eating pattern and early asymptomatic atherosclerosis. Journal of the American College of Cardiology. doi: 10.1016/j.jacc.2016.05.080.

Coronary diet intervention with olive oil and cardiovascular prevention study (the CORDIOPREV study); rationale, methods, and baseline characteristics: a clinical trial comparing the efficacy of a Mediterranean diet rich... - (Peer Reviewed Journal)
Delgado-Lista, J., Perez-Martinez, P., Garcia-Rios, A., Alcala-Diaz, J.F., Perez-Caballero, A.I., Gomez-Delgado, F., Fuentes, F., Quintana-Navarro, G., Lopez-Segura, F., Ortiz-Morales, A.M., Delgado-Casado, N., Yubero-Serrano, E.M., Camargo, A., Marin, C., Rodriguez-Cantalejo, F., Gomez-Luna, P., Ordovas, J.M., Lopez-Miranda, J., Perez-Jimenez, F. 2016. Coronary diet intervention with olive oil and cardiovascular prevention study (the CORDIOPREV study); rationale, methods, and baseline characteristics: a clinical trial comparing the efficacy of a Mediterranean diet rich in olive oil versus a low-fat diet on cardiovascular disease in coronary patients. American Heart Journal. doi: 10.1016/j.ahj.2016.04.011.

Influence of obesity and metabolic disease on carotid atherosclerosis in patients with coronary artery disease (CordioPrev study) - (Peer Reviewed Journal)
Talavera-Garcia, E., Delgado-Lista, J., Garcia-Rios, A., Delgado-Casado, N., Gomez-Luna, P., Gomez-Garduño, A., Gomez-Delgado, F., Alcala-Diaz, J.F., Yubero-Serrano, E., Marin, C., Perez-Caballero, A.I., Fuentes-Jimenez, F.J., Camargo, A., Rodriguez-Cantalejo, F., Tinahones, F.J., Ordovas, J.M., Perez- Jimenez, F., Perez-Martinez, P., Lopez-Miranda, J. 2016. Influence of obesity and metabolic disease on carotid atherosclerosis in patients with coronary artery disease (CordioPrev study). PLoS One. doi: 10.1371/journal.pone.0157213.

A genome-wide study of lipid response to fenofibrate in Caucasians: a combined analysis of the GOLDN and ACCORD studies - (Peer Reviewed Journal)
Irvin, M.R., Rotroff, D.M., Aslibekyan, S., Zhi, D., Hidalgo, B., Motsinger-Reif, A., Marvel, S., Srinivasainagendra, V., Claas, S.A., Buse, J.B., Straka, R.J., Ordovas, J.M., Borecki, I.B., Guo, X., Chen, I.Y., Rotter, J.I., Wagner, M.J., Arnett, D.K. 2016. A genome-wide study of lipid response to fenofibrate in Caucasians: a combined analysis of the GOLDN and ACCORD studies. Pharmacogenetics and Genomics. 26(7):324-333.

Nutrigenomics, the microbiome, and gene environment interactions: new directions in cardiovascular disease research, prevention, and treatment. A scientific statement From the American Heart Association - (Review Article)
Ferguson, J.F., Allayee, H., Gerszten, R.E., Ideraabdullah, F., Kris-Etherton, P.M., Ordovas, J.M., Rimm, E.B., Wang, T.J., Bennett, B.J. 2016. Nutrigenomics, the microbiome, and gene environment interactions: new directions in cardiovascular disease research, prevention, and treatment. A scientific statement From the American Heart Association. Circulation: Cardiovascular Genetics. 9(3):291-313.

The omega-3 index is inversely associated with depressive symptoms among individuals with elevated oxidative stress biomarkers - (Peer Reviewed Journal)
Bigornia, S.J., Harris, W.S., Falcon, L.M., Ordovas, J.M., Lai, C., Tucker, K.L. 2016. The omega-3 index is inversely associated with depressive symptoms among individuals with elevated oxidative stress biomarkers. Journal of Nutrition. 146(4):758-766. doi: 10.3945/jn.115.222562.

Unsuccessful detection of plant microRNAs in beer, extra virgin olive oil and human plasma after an acute ingestion of extra virgin olive oil - (Peer Reviewed Journal)
Mico, V., Martin, R., Lasuncion, M., Ordovas, J.M., Daimiel, L. 2016. Unsuccessful detection of plant microRNAs in beer, extra virgin olive oil and human plasma after an acute ingestion of extra virgin olive oil. Plant Foods for Human Nutrition. doi: 10.1007/s11130-016-0534-9.

Actigraphic sleep fragmentation, efficiency and duration associate with dietary intake in the Rotterdam study - (Peer Reviewed Journal)
Dashti, H.S., Zuurbier, L.A., De Jonge, E., Voortman, T., Jacques, P.F., Lamon-Fava, S., Scheer, F.A., Kiefte-De Jong, J.C., Hofman, A., Ordovas, J.M., Franco, O.H., Tiemeier, H. 2016. Actigraphic sleep fragmentation, efficiency and duration associate with dietary intake in the Rotterdam study. Journal of Sleep Research. doi: 10.1111/jsr.12397.

Rare variant in scavenger receptor BI raises HDL cholesterol and increases risk of coronary heart disease - (Peer Reviewed Journal)
Zanoni, P., Khetarpal, S.A., Larach, D.B., Hancock-Cerutti, W.F., Millar, J.S., Cuchel, M., Derohannessian, S., Kontush, A., Surendran, P., Saleheen, D., Trompet, S., Jukema, J., De Craen, A., Deloukas, P., Sattar, N., Ford, I., Packard, C., Majumder, A., Alam, D.S., Angelantonio, E.D., Abecasis, G., Chowdhury, R., Erdmann, J., Nordestgaard, B.G., Nielsen, S.F., Tybjaerg-Hansen, A., Schmidt, R.F., Kuulasmaa, K., Liu, D., Perola, M., Blankenberg, S., Salomaa, V., Mannisto, S., Amouyel, P., Arveiler, D., Ferrieres, J., Muller-Nurasyid, M., Ferrario, M., Kee, F., Willer, C.J., Samani, N., Schunkert, H., Butterworth, A.S., Howson, J.M., Peloso, G.M., Stitziel, N.O., Danesh, J., Kathiresan, S., Rader, D.J., Ordovas, J.M. 2016. Rare variant in scavenger receptor BI raises HDL cholesterol and increases risk of coronary heart disease. Science. doi: 10.1126/science.aad3517.

Circadian rhythms, metabolism, and chrononutrition in rodents and humans - (Review Article)
Johnston, J.D., Ordovas, J.M., Scheer, F.A., Turek, F.W. 2016. Circadian rhythms, metabolism, and chrononutrition in rodents and humans. Advances in Nutrition. doi: 10.3945/an.115.010777.

CLOCK gene variation is associated with incidence of type-2 diabetes and cardiovascular diseases in type-2 diabetic subjects: dietary modulation in the PREDIMED randomized trial - (Peer Reviewed Journal)
Corella, D., Asensio, E.M., Coltell, O., Sorli, J.V., Estruch, R., Martinez-Gonzalez, M., Salas-Salvadó, J., Castañer, O., Arós, F., Lapetra, J., Serra-Majem, L., Gómez-Gracia, E., Ortega-Azorín, C., Fiol, M., Espino, J.D., Díaz-López, A., Fitó, M., Ros, E., Ordovas, J.M. 2016. CLOCK gene variation is associated with incidence of type-2 diabetes and cardiovascular diseases in type-2 diabetic subjects: dietary modulation in the PREDIMED randomized trial. Cardiovascular Diabetology. 15:4. doi: 10.1186/s12933-015-0327-8.

Femoral and carotid subclinical atherosclerosis association with risk factors and coronary calcium: the AWHS study - (Peer Reviewed Journal)
Laclaustrta, M., Casasnovas, J.A., Fernandes-Ortiz, A., Fuster, V., Leon-Latre, M., Jimenez Borreguero, L.J., Pocovi, M.M., Hurtado-Roca, Y., Ordovas, J.M., Jarauta, E., Guallar, E., Ibanez, B., Civeira, F. 2016. Femoral and carotid subclinical atherosclerosis association with risk factors and coronary calcium: the AWHS study. Journal of the American College of Cardiology. doi: 10.1016/j.jacc.2015.12.056.

Interaction of methylation-related genetic variants with circulating fatty acids on plasma lipids: a meta-analysis of 7 studies & methylation analysis of 3 studies in the Cohorts for Heart & Aging Research - (Peer Reviewed Journal)
Ma, Y., Follis, J., Smith, C.E., Tanaka, T., Manichaikl, A., Chu, A.Y., Samieri, C., Zhou, X., Guan, W., Wang, L., Biggs, M., Chen, Y., Hernandez, D., Borecki, I.B., Chasman, D.I., Rich, S.S., Ferrucci, L., Irvin, M.R., Aslibekyan, S., Zhi, D., Tiwari, H.K., Claas, S.A., Sha, J., Kabagambe, E.K., Lai, C., Parnell, L.D., Lee, Y., Amouyel, P., Lambert, J., Psaty, B.M., King Irena, Mozaffarian, D., Mcknight, B., Bandinelli, S., Tsai, M.Y., Ridker, P.M., Ding, J., Mstat, K.L., Liu, Y., Sotoodehnia, N., Barberger-Gateau, P., Steffen, L.M., Siscovick, D.S., Absher, D.M., Arnett, D.K., Ordovas, J.M., Lemaitre, R.N. 2016. Interaction of methylation-related genetic variants with circulating fatty acids on plasma lipids: a meta-analysis of 7 studies & methylation analysis of 3 studies in the Cohorts for Heart & Aging Research. American Journal of Clinical Nutrition. doi: 10.3945/ajcn.115.112987.

Association of DNA methylation at CPT1A locus with metabolic syndrome in the Genetics of Lipid Lowering Drugs and Diet Network (GOLDN) Study - (Peer Reviewed Journal)
Das, M., Sha, J., Hidalgo, B., Aslibekyan, S., Do, A.N., Zhi, D., Sun, D., Zhang, T., Li, S., Chen, W., Srinivasan, S., Tiwari, H.K., Absher, D.M., Ordovas, J.M., Berenson, G.S., Arnett, D.K., Irvin, M.R. 2016. Association of DNA methylation at CPT1A locus with metabolic syndrome in the Genetics of Lipid Lowering Drugs and Diet Network (GOLDN) Study. PLoS One. 11(1):e0145789. https://doi.org/10.1371/journal.pone.0145789.

Physical activity attenuates the effect of the FTO genotype on obesity-related traits in European adults: Findings from the Food4Me study - (Peer Reviewed Journal)
Celis-Morales, C., Marsaux, C.F., Livingstone, K.M., Navas-Carretero, S., San-Cristobal, R., O'Donovan, C.B., Forster, H., Woolhead, C., Fallaize, R., Macready, A.L., Kolossa, S., Hallmann, J., Tsirigoti, L., Lambrinou, C.P., Moschonis, G., Godlewska, M., Surwillo, A., Grimaldi, K., Bouwman, J., Manios, Y., Traczyk, I., Drevon, C.A., Parnell, L.D., Daniel, H., Gibney, E.R., Brennan, L., Walsh, M., Gibney, M., Lovegrove, J.A., Martinez, J., Saris, W.H., Mathers, J.C. 2016. Physical activity attenuates the effect of the FTO genotype on obesity-related traits in European adults: Findings from the Food4Me study. International Journal of Obesity. 24:962-969. doi: 10.1002/oby.21422.

The integration of epigenetics and genetics in nutrition research for CVD risk factors - (Review Article)
Ma, Y., Ordovas, J.M. 2016. The integration of epigenetics and genetics in nutrition research for CVD risk factors. Proceedings of the Nutrition Society. doi: 10.1017/S0029665116000823.

Functional genomics analysis of big data identifies novel PPARy target SNPs showing association with cardio metabolic outcomes - (Peer Reviewed Journal)
Richardson, K., Schnitzler, G.R., Lai, C., Ordovas, J.M. 2015. Functional genomics analysis of big data identifies novel PPARy target SNPs showing association with cardio metabolic outcomes. Circulation: Cardiovascular Genetics. 8(6):842-851.

The effects of omega-3 polyunsaturated fatty acids and genetic variants on methylation levels of the interleukin-6 gene promoter - (Peer Reviewed Journal)
Ma, Y., Smith, C.E., Lai, C., Irvin, M.R., Parnell, L.D., Lee, Y., Pham, L.D., Aslibekyan, S., Claas, S.A., Tsai, M.Y., Borecki, I.B., Kagambe, E.K., Ordovas, J.M., Absher, D., Arnett, D.K. 2016. The effects of omega-3 polyunsaturated fatty acids and genetic variants on methylation levels of the interleukin-6 gene promoter. Epigenetics. 60(2):410-419. doi: 10.1002/mnfr.201500436.

Short sleep duration and dietary intake: epidemiologic evidence, mechanisms, and health implications - (Review Article)
Dashti, H.S., Scheer, F.A., Jacques, P.F., Lamon-Fava, S., Ordovas, J.M. 2015. Short sleep duration and dietary intake: epidemiologic evidence, mechanisms, and health implications. Advances in Nutrition. 6:648–659. doi: 10.3945/an.115.008623.

Lower-normal TSH is associated with better metabolic risk factors: a cross-sectional study on spanish men - (Peer Reviewed Journal)
Laclaustra, M., Hurtado-Roca, L., Sendin, M., Leon, M., Ledesma, M., Andres, E., Fernandez-Ortiz, A.I., Guallar, E., Ordovas, J.M., Casasnovas Lenguas, J. 2015. Lower-normal TSH is associated with better metabolic risk factors: a cross-sectional study on spanish men. Nutrition, Metabolism and Cardiovascular Diseases. 25:1095-1103.

Genetics and gene-environment interactions on longevity and lifespan - (Book / Chapter)
Lai, C., Ma, Y., Parnell, L.D. 2016. Genetics and gene-environment interactions on longevity and lifespan. In: Qi, L., Editor. Gene-Environment Interactions and Human Diseases. Hauppauge, NY: Nova Science Publishers, Inc. p. 245-264.

Genome-wide association study of triglyceride response to a high-fat meal among participants of the NHLBI genetics of lipid lowering drugs and diet network (GOLDN) - (Peer Reviewed Journal)
Wojczynski, M.K., Parnell, L.D., Pollin, T.I., Lai, C., Feitosa, M.F., O'Connel, J.R., Frazier-Wood, A.C., Gibson, Q., Aslibkeyan, S., Ryan, K.A., Province, M.A., Tiwari, H.K., Ordovas, J.M., Shuldiner, A.R., Arnett, D.K., Borecki, I.B. 2015. Genome-wide association study of triglyceride response to a high-fat meal among participants of the NHLBI genetics of lipid lowering drugs and diet network (GOLDN). Metabolism. 64:1359-1371.

Validation of internet-based self-reported anthropometric, demographic data and participant identity in the Food4Me study - (Peer Reviewed Journal)
Celis-Morales, C., Livingstone, K.M., Woolhead, C., Forster, H., O'Donovan, C.B., Macready, A.L., Fallaize, R., Marsaux, C.F., Tsirigoti, L., Efstathopoulou, E., Moschonis, G., Navas-Carretero, S., San-Cristobal, R., Kolossa, S., Godlewska, M., Surwillo, A., Drevon, C.A., Gjelstad, I.F., Karlsen, A.S., Bouwman, J., Grimaldi, K., Parnell, L.D., Manios, Y., Traczyk, I., Gibney, E.R., Brrennan, L., Hallmann, J., Walsh, M.C., Lovegrove, J.A., Martinez, J., Daniel, H., Saris, W.H., Gibney, M., Mathers, J.C. 2015. Validation of internet-based self-reported anthropometric, demographic data and participant identity in the Food4Me study. International Journal of Obesity. 10:476.

Guide and position of the International Society of Nutrigenetics/Nutrigenomics on personalised nutrition: Part 1 - fields of precision nutrition - (Review Article)
Ferguson, L.R., De Caterina, R., Gorman, U., Allayee, H., Kohlmeier, M., Prasad, C., Choi, M., Curi, R., De Luis, D., Gil, A., Kang, J.X., Martin, R.L., Milagro, F.I., Nicoletti, C.F., Nonino, C., Ordovas, J.M., Parslow, V.R., Portillo, M.P., Santos, J., Serhan, C.N., Simopoulos, A.P., Velazques-Arellano, A., Zulet, M., Martinez, J. 2016. Guide and position of the International Society of Nutrigenetics/Nutrigenomics on personalised nutrition: Part 1 - fields of precision nutrition. Jounal of Nutrigenetics and Nutrigenomics. 9:12-27.

Gene x dietary pattern interactions in obesity: analysis of up to 68,317 adults of European ancestry - (Peer Reviewed Journal)
Nettleton, J.A., Follis, J.L., Ngwa, J.S., Smith, C.E., Shafqat, A., Tanaka, T., Wojczynski, M.K., Voortman, T., Lemaitre, R.N., Kristiansson, K., Nuotio, M., Houston, D.K., Perala, M., Qi, Q., Sonestedt, E., Manichaikul, A., Kanoni, S., Ganna, A., Mikkila, V., North, K.E., Siscovick, D.S., Harald, K., McKeown, N.M., Johansson, I., Rissanen, H., Liu, Y., Lahti, J., Hu, F., Bandinelli, S.B., Rukh, G., Rich, S., Booij, L., Dmitriou, M., Ax, E., Raitakari, O., Mukamal, K., Mannisto, S., Hallmans, G., Jula, A., Ericson, U., Jacobs, D.R., Van Rooij, F.J., Deloukas, P., Sjogren, P., Kahonen, M., Djousse, L., Perola, M., Barroso, I., Hofman, A., Stirrups, K., Viikari, J., Uitterlinden, A.G., Kalafati, I.P., Franco, O.H., Mozaffarian, D., Salomaa, V., Borecki, I.B., Knekt, P., Kritchevsky, S.B., Eriksson, J.G., Dedoussis, G.V., Qi, L., Ferrucci, L., Orho-Melander, M., Zillikens, M., Ingelsson, E., Lehtimaki, T., Renstrom, F., Cupples, L., Loos, R., Franks, P.W. 2015. Gene x dietary pattern interactions in obesity: analysis of up to 68,317 adults of European ancestry. Human Molecular Genetics. https://doi.org/10.1093/hmg/ddv186.

Gene-environment interactions of circadian-related genes for cardiometabolic traits - (Peer Reviewed Journal)
Dashti, H., Follis, J.L., Smith, C.E., Tanaka, T., Garaulet, M.A., Gottlieb, D.J., Hruby, A., Jacques, P.F., Kiefte-De Jong, J.C., Lamon-Fava, S., Scheer, F.A., Bartz, T.M., Kovanen, L., Wojczynski, M.K., Frazier-Wood, A.C., Ahluwalia, T.S., Perala, M., Jonsson, A., Muka, T., Kalafati, I.P., Mikkila, V., Ordovas, J.M. 2015. Gene-environment interactions of circadian-related genes for cardiometabolic traits. Diabetes Care. 1-11. https://doi.org/10.2337/dc14-2709.

Network-based characterization of inflammation biomarkers, phytochemicals and disease - (Abstract Only)
Kamanu, F., Zirkler, E., Obin, M.S., Ordovas, J.M., Parnell, L.D., Smith, C.E. 2015. Network-based characterization of inflammation biomarkers, phytochemicals and disease. Journal of Federation of American Societies for Experimental Biology. 29(1):923.18.

Environmental chemicals and DNA methylation in adults: a systematic review of the epidemiologic evidence - (Review Article)
Ruiz-Hernandez, A., Kuo, C., Rentero-Garrido, P., Tang, W., Redon, J., Ordovas, J.M., Navas-Acien, A., Tellez-Plasza, M. 2015. Environmental chemicals and DNA methylation in adults: a systematic review of the epidemiologic evidence. Journal of Clinical Epigenetics. 7:55. https://doi.org/10.1186/s13148-015-0055-7.

Dietary fatty acids modulate associations between genetic variants and circulating fatty acids in plasma and erythrocyte membranes: meta-analysis of nine studies in the CHARGE consortium - (Peer Reviewed Journal)
Smith, C.E., Follis, J.L., Nettleton, J.A., Foy, M., Wu, J.H., Ma, Y., Tanaka, T., Manichakul, A.W., Wu, H., Chu, A.Y., Steffen, L.M., Fornage, M., Mozaffarian, D., Kabagambe, E.K., Ferruci, L., Chen, Y., Rich, S.S., Djousse, L., Ridker, P.M., Tang, W., Mcknight, B., Tsai, M.Y., Bandinelli, S., Rotter, J.I., Hu, F.B., Chasman, D.I., Psaty, B.M., Arnett, D.K., King, I.B., Sun, Q., Wang, L., Lumley, T., Chiuve, S.E., Siscovick, D.S., Ordovas, J.M., Lemaitre, R.N. 2015. Dietary fatty acids modulate associations between genetic variants and circulating fatty acids in plasma and erythrocyte membranes: meta-analysis of nine studies in the CHARGE consortium. Molecular Nutrition and Food Research. 59(7):1373-1383. https://doi.org/10.1002/mnfr.201400734.

Biomarkers: background, classification and guidelines for applications in nutritional epidemiology - (Review Article)
Corella, D., Ordovas, J.M. 2015. Biomarkers: background, classification and guidelines for applications in nutritional epidemiology. Nutricion Hospitalaria. 31(3):177-188. https://doi.org/10.3305/nh.2015.31.sup3.8765.

PRKCZ methylation is associated with sunlight exposure in a North American but not a Mediterranean population - (Peer Reviewed Journal)
Aslibekyan, S., Dashti, H., Tanaka, T., Sha, J., Ferrucci, L., Zhi, D., Bandinelli, S., Borecki, I., Absher, D.M., Arnett, D.K., Ordovas, J.M. 2014. PRKCZ methylation is associated with sunlight exposure in a North American but not a Mediterranean population. Chronobiology International. 31(9):1034-1040. https://doi.org/10.3109/07420528.2014.944266.