Research Project: Detection and Fate of Chemical and Biological Residues in Food and Environmental Systems

Location: Food Animal Metabolism Research

Publications (Clicking on the reprint icon will take you to the publication reprint.)

Urinary concentrations of triclosan, bisphenol A, and brominated flame retardant in the association of triclosan with demographic characteristics and body fatness among women with newly diagnosed breast cancer - (Peer Reviewed Journal)
Ilozumba, M., Shelver, W.L., Hong, C., Ambrosone, C.B., Cheng, T.D. 2022. Urinary concentrations of triclosan, bisphenol A, and brominated flame retardant in the association of triclosan with demographic characteristics and body fatness among women with newly diagnosed breast cancer. International Journal of Environmental Research and Public Health. 19. Article 4681. https://doi.org/10.3390/ijerph19084681.

Perfluorooctanoic acid (PFOA) transport in soil and absorption and distribution in alfalfa (Medicago sativa) - (Peer Reviewed Journal)
Lupton, S.J., Casey, F., Smith, D.J., Hakk, H. 2021. Perfluorooctanoic acid (PFOA) transport in soil and absorption and distribution in alfalfa (Medicago sativa). Journal of Food Protection. 85:164-172. https://doi.org/10.4315/JFP-21-276.

Micro/nanoplastic mediated pathophysiological changes in rodents, rabbits, and chicken - (Review Article)
Banerjee, A., Shelver, W.L. 2021. Micro/nanoplastic mediated pathophysiological changes in rodents, rabbits, and chicken. Journal of Food Protection. https://doi.org/10.4315/JFP-21-117.

Absorption, distribution, metabolism, and excretion of three [14C]PBDE congeners in laying hens and transfer to eggs - (Peer Reviewed Journal)
Hakk, H., Pfaff, C.M., Lupton, S.J., Singh, A. 2020. Absorption, distribution, metabolism, and excretion of three [14C]PBDE congeners in laying hens and transfer to eggs. Xenobiotica. 51:335-344. https://doi.org/10.1080/00498254.2020.1860269.

Perfluorooctanoic acid (PFOA) uptake by alfalfa (Medicago sativa) and bioavailability in Sprague-Dawley rats - (Peer Reviewed Journal)
Lupton, S.J., Hakk, H. 2020. Perfluorooctanoic acid (PFOA) uptake by alfalfa (Medicago sativa) and bioavailability in Sprague-Dawley rats. Journal of Food Protection. 84:688–694. https://doi.org/10.4315/JFP-20-389.

Surveillance of plasticizers, bisphenol A, steroids and caffeine in surface water of River Ganga and Sundarban wetland along the Bay of Bengal: occurrence, sources, estrogenicity screening and ecotoxicological risk assessment - (Peer Reviewed Journal)
Chakraborty, P., Shappell, N.W., Mukhopadhyay, M., Onanong, S., Rex, K., Snow, D. 2020. Surveillance of plasticizers, bisphenol A, steroids and caffeine in surface water of River Ganga and Sundarban wetland along the Bay of Bengal: occurrence, sources, estrogenicity screening and ecotoxicological risk assessment. Water Research. https://doi.org/10.1016/j.watres.2020.116668.

Micro- and nanoplastic induced cellular toxicity in mammals: A review - (Peer Reviewed Journal)
Banerjee, A., Shelver, W.L. 2020. Micro- and nanoplastic induced cellular toxicity in mammals: A review. Science of the Total Environment. 755:142518. https://doi.org/10.1016/j.scitotenv.2020.142518.

Estrogenicity of agricultural runoff: A rainfall simulation study of worst-case scenarios using fresh layer and roaster litter, and farrowing swine manure - (Peer Reviewed Journal)
Shappell, N., Shipitalo, M., Billey, L.O. 2020. Estrogenicity of agricultural runoff: A rainfall simulation study of worst-case scenarios using fresh layer and roaster litter, and farrowing swine manure. Science of the Total Environment. 750:141188. https://doi.org/10.1016/j.scitotenv.2020.141188.

Electrospray ionization rapid screening (ESI-RS) sans LC column: A sensitive method for detection and quantification of chemicals in animal tissues and urine - (Peer Reviewed Journal)
Chakrabarty, S., Shelver, W.L., Smith, D.J. 2020. Electrospray ionization rapid screening (ESI-RS) sans LC column: A sensitive method for detection and quantification of chemicals in animal tissues and urine. Rapid Communications in Mass Spectrometry. 34:8876. https://doi.org/10.1002/rcm.8876.

Distribution and chemical fate of [36Cl]chlorine dioxide gas on avocados, eggs, onions, and sweet potatoes - (Peer Reviewed Journal)
Smith, D.J., Scapanski, A.R. 2020. Distribution and chemical fate of [36Cl]chlorine dioxide gas on avocados, eggs, onions, and sweet potatoes. Journal of Agricultural and Food Chemistry. 68:5000-5008. https://doi.org/10.1021/acs.jafc.0c01466.

Pharmacokinetic parameters and estimated milk withdrawal intervals for domestic goats (Capra aegagrus hircus) after administration of single and multiple intravenous and subcutaneous doses of flunixin meglumine - (Peer Reviewed Journal)
Smith, J.S., Marmulak, T.L., Angelos, J.A., Lin, Z., Rowe, J.D., Carlson, J.L., Shelver, W.L., Lee, E.A., Tell, L.A. 2020. Pharmacokinetic parameters and estimated milk withdrawal intervals for domestic goats (Capra aegagrus hircus) after administration of single and multiple intravenous and subcutaneous doses of flunixin meglumine. Frontiers in Veterinary Science. 7:213. https://doi.org/10.3389/fvets.2020.00213.

Electrospray ionization inlet tandem mass spectrometry: A hyphenated method for the sensitive determination of chemicals in animal tissues and body fluids - (Peer Reviewed Journal)
Chakrabarty, S., Shelver, W.L., Smith, D.J. 2021. Electrospray ionization inlet tandem mass spectrometry: A hyphenated method for the sensitive determination of chemicals in animal tissues and body fluids. Journal of American Society for Mass Spectrometry. 32:14-20. https://doi.org/10.1021/jasms.9b00114.

Reproductive performance of mares fed dietary zearalenone - (Peer Reviewed Journal)
Vance, C.K., King, E., Bowers, S.D., Ryan, P.L., Walters, K., Shappell, N.W. 2019. Reproductive performance of mares fed dietary zearalenone. Frontiers in Veterinary Science. 6:423. https://doi.org/doi: 10.3389/fvets.2019.00423.

Free and conjugated estrogens detections in drainage tiles and wells beneath fields receiving swine manure slurry - (Peer Reviewed Journal)
Casey, F.X., Hakk, H., Desutter, T.M. 2020. Free and conjugated estrogens detections in drainage tiles and wells beneath fields receiving swine manure slurry. Environmental Pollution. 256. https://doi.org/10.1016/j.envpol.2019.113384.

An in vitro comparison of estrogenic equivalents per serving size of some common foods - (Peer Reviewed Journal)
Shappell, N.W., Berg, E.P., Magolski, J.D., Billey, L.O. 2019. An in vitro comparison of estrogenic equivalents per serving size of some common foods. Journal of Food Science. https://doi.org/10.1111/1750-3841.14847.

An in vitro comparison of estrogenic equivalents per serving size of some common foods - (Peer Reviewed Journal)
Shappell, N.W., Berg, E.P., Magolski, J., Billey, L.O. 2019. An in vitro comparison of estrogenic equivalents per serving size of some common foods. Journal of Food Science. 84(12):3876-3884. https://doi.org/10.1111/1750-3841.14847.

Evaluation of waterborne estrogenic activity at a land-based, water recirculation aquaculture facility using E-screen - (Abstract Only)
Shappell, N.W., Good, C.M., Harper, S.B., Davidson, J., Harrison, C.E. 2019. Evaluation of waterborne estrogenic activity at a land-based, water recirculation aquaculture facility using E-screen [abstract]. 40th Annual Mtg of North American Society of Environmental Toxicology and Chemistry. November 3 - 7, 2019. Toronto, Canada. Poster No. 354.

Estrogenicity of agricultural runoff: rainfall simulation study of worst-case scenarios using fresh farrowing swine manure, layer and broiler litter - (Abstract Only)
Shappell, N.W., Billey, L.O., Shipitalo, M.J. 2019. Estrogenicity of agricultural runoff: rainfall simulation study of worst-case scenarios using fresh farrowing swine manure, layer and broiler litter [abstract]. 40th Annual Mtg of North American Society of Environmental Toxicology and Chemistry. November 3 - 7, 2019. Toronto, Canada. Poster No. PC021.

Detection and quantification of residues in sheep exposed to trace levels of dietary zilpaterol HCl - (Peer Reviewed Journal)
Smith, D.J., Shelver, W.L., Chakrabarty, S., Hoffman, T.W. 2019. Detection and quantification of residues in sheep exposed to trace levels of dietary zilpaterol HCl. Food Additives & Contaminants: Part A. 36(9):1289-1301. https://doi.org/10.1080/19440049.2019.1627005.

Assessment of veterinary drugs present in pork kidney purchased from a Midwest US retail market - (Peer Reviewed Journal)
Shelver, W.L., Mcgarvey, A.M. 2019. Assessment of veterinary drugs present in pork kidney purchased from a Midwest US retail market. Food Additives & Contaminants: Part A. 36(4):571-581. https://doi.org/10.1080/19440049.2019.1586455.

In vitro subcellular characterization of flunixin liver metabolism in heifers, steers, and cows - (Peer Reviewed Journal)
Shappell, N.W., Duke, S.E., Bartholomay, K.A. 2019. In vitro subcellular characterization of flunixin liver metabolism in heifers, steers, and cows. Research in Veterinary Science. 123:118-123. https://doi.org/10.1016/j.rvsc.2018.12.012.

Atmospheric solid analysis probe and modified desorption electrospray ionization mass spectrometry for rapid screening and semi-quantification of zilpaterol in urine and tissues of sheep - (Peer Reviewed Journal)
Chakrabarty, S., Shelver, W.L., Hakk, H., Smith, D.J. 2018. Atmospheric solid analysis probe and modified desorption electrospray ionization mass spectrometry for rapid screening and semi-quantification of zilpaterol in urine and tissues of sheep. Journal of Agricultural and Food Chemistry. 66(41):10871-10880. https://doi.org/10.1021/acs.jafc.8b03925.

Distribution of chemical residues among fat, skim, curd, whey, and protein fractions in fortified, pasteurized milk - (Peer Reviewed Journal)
Shelver, W.L., Lupton, S.J., Shappell, N.W., Smith, D.J., Hakk, H. 2018. Distribution of chemical residues among fat, skim, curd, whey, and protein fractions in fortified, pasteurized milk. ACS Omega. 3(8):8697-8708. https://doi.org/10.1021/acsomega.8b00762.

Urinary excretion and tissue residues of zilpaterol HCl after trace-level exposures - (Abstract Only)

Fate and transport of brominated estradiols as surrogates for native 17ß-estradiol in an agricultural field - (Abstract Only)

Development of an immunochromatographic assay for the ß-adrenergic agonist feed additive zilpaterol - (Peer Reviewed Journal)
Shelver, W.L., Smith, D.J. 2018. Development of an immunochromatographic assay for the ß-adrenergic agonist feed additive zilpaterol. Food Additives & Contaminants: Part A. 35(8):1519-1529. https://doi.org/10.1080/19440049.2018.1463568.

Determination of zilpaterol in sheep urine and tissues using immunochromatographic assay - (Abstract Only)

Fluorescent microarray for multiplexed quantification of environmental contaminants in seawater samples - (Peer Reviewed Journal)
Sanchis, A., Salvador, J.P., Campbell, K., Elliott, C.T., Shelver, W.L., Li, Q.X., Marco, M.P. 2018. Fluorescent microarray for multiplexed quantification of environmental contaminants in seawater samples. Talanta. 184:499-506. https://doi.org/10.1016/j.talanta.2018.03.036.

Rapid semi-quantification of zilpaterol from biological matrices using ASAP and DESI-like MS from a commercial heated electrospray ionization probe - (Abstract Only)

Use of fixed ratios in mixture studies, in vitro evidence of issues - (Other)
Shappell, N.W. 2018. Use of fixed ratios in mixture studies, in vitro evidence of issues. Integrated Environmental Assessment and Management. 14(3):420-422. https://doi.org/10.1002/ieam.4038.

Chloroxyanion residue on seeds and sprouts after chlorine dioxide sanitation of alfalfa seed - (Peer Reviewed Journal)
Smith, D.J., Herges, G.R. 2018. Chloroxyanion residue on seeds and sprouts after chlorine dioxide sanitation of alfalfa seed. Journal of Agricultural and Food Chemistry. 66(8):1974-1980. https://doi.org/10.1021/acs.jafc.7b05953.

The distribution of environmental contaminants and pharmaceuticals among skim milk, milk fat, curd, whey, and milk protein fractions through milk processing - (Abstract Only)
Shelver, W.L., Lupton, S.J., Shappell, N.W., Hakk, H., Smith, D.J. 2017. The distribution of environmental contaminants and pharmaceuticals among skim milk, milk fat, curd, whey, and milk protein fractions through milk processing [abstract]. 8th International Symposium on Recent Advances in Food Analysis. Nov. 7-10, 2017. Prague, Czech Republic. Paper No. L107.

Do environmental factors affect male fathead minnow (Pimephales promelas) response to estrone? Part 2. Temperature and food availability - (Peer Reviewed Journal)
Shappell, N.W., Feifarek, D.J., Rearick, D.C., Bartell, S.E., Schoenfuss, H.L. 2018. Do environmental factors affect male fathead minnow (Pimephales promelas) response to estrone? Part 2. Temperature and food availability. Science of the Total Environment. 610–611:32–43. https://doi.org/10.1016/j.scitotenv.2017.08.021.

Do environmental factors affect male fathead minnow (Pimephales promelas) response to estrone? Part 1. Dissolved oxygen and sodium chloride - (Peer Reviewed Journal)
Feifarek, D.J., Shappell, N.W., Schoenfuss, H.L. 2018. Do environmental factors affect male fathead minnow (Pimephales promelas) response to estrone? Part 1. Dissolved oxygen and sodium chloride. Science of the Total Environment. 610-611:1262-1270. http://dx.doi.org/10.1016/j.scitotenv.2017.07.251.

Stability of sodium chlorate residues in frozen tomato and cantaloupe homogenates - (Peer Reviewed Journal)
Smith, D.J., Herges, G.R. 2017. Stability of sodium chlorate residues in frozen tomato and cantaloupe homogenates. Journal of Agricultural and Food Chemistry. 65(30):6258-6263. doi:10.1021/acs.jafc.7b02520.

Estrogenic activity, estrogens, and calcium in runoff post-layer litter application from rainfall simulated events - (Abstract Only)
Shappell, N.W., Shipitalo, M.J., Billey, L.O. 2017. Estrogenic activity, estrogens, and calcium in runoff post-layer litter application from rainfall simulated events [abstract]. 38th Annual Society of Environmental Toxicology and Chemistry North American Mtg., November 12-16, Minneapolis, MN. Abstract #547. p. 134.

Comparison of immunomagnetic separation beads for detection of six Non-O157:H7 shiga toxin-producing Escherichia coli serogroups in different matrices - (Peer Reviewed Journal)
Kraft, A.L., Lacher, D.W., Shelver, W.L., Sherwood, J.S., Bergholz, T.M. 2017. Comparison of immunomagnetic separation beads for detection of six non-O157 Shiga toxin-producing Escherichia coli serogroups in different matrices. Letters in Applied Microbiology. 65(3):213-219. https://doi.org/10.1111/lam.12771.

Development of an immunochromatographic assay for the detection of the feed additive zilpaterol - (Abstract Only)
Shelver, W.L., Smith, D.J. 2017. Development of an immunochromatographic assay for the detection of the feed additive zilpaterol [abstract]. 54th Annual North American Chemical Residue Workshop. July 23-26, 2017. Naples, FL. p. 68.

Absorption and elimination of [14C]-Dicoumarol in goats - (Proceedings)
Chakrabarty, S., Smith, D.J. 2017. Absorption and elimination of [14C]-Dicoumarol in goats. Proceedings of Western Section American Society of Animal Science. 68:188-191.

Comparison of lateral flow assay, kidney inhibition swab, and liquid chromatography-tandem mass spectrometry for the detection of penicillin G residues in sow urine - (Peer Reviewed Journal)
Shelver, W.L., Chakrabarty, S., Smith, D.J. 2017. Comparison of lateral flow assay, kidney inhibition swab, and liquid chromatography-tandem mass spectrometry for the detection of penicillin G residues in sow urine. Journal of Agricultural and Food Chemistry. 65:1778-1783. doi:10.1021/acs.jafc.6b05049.

Distribution of animal drugs among curd, whey, and milk protein fractions in spiked skim milk and whey - (Peer Reviewed Journal)
Shappell, N.W., Shelver, W.L., Lupton, S.J., Fanaselle, W., Van Doren, J.M., Hakk, H. 2017. Distribution of animal drugs among curd, whey, and milk protein fractions in spiked skim milk and whey. Journal of Agricultural and Food Chemistry. 65:938-949. doi:10.1021/acs.jafc.6b04258.

Distribution of flunixin residues in muscles of dairy cattle dosed with lipopolysaccharide or saline and treated with flunixin by intravenous or intramuscular injection - (Peer Reviewed Journal)
Shelver, W.L., Schneider, M.J., Smith, D.J. 2016. Distribution of flunixin residues in muscles of dairy cattle dosed with lipopolysaccharide or saline and treated with flunixin by intravenous or intramuscular injection. Journal of Agricultural and Food Chemistry. 64:9697-9701. doi:10.1021/acs.jafc.6b04792.

Distribution, identification, and quantification of residues after treatment of ready-to-eat salami with 36Cl-labeled or nonlabeled chlorine dioxide gas - (Peer Reviewed Journal)
Smith, D.J., Giddings, J.M., Herges, G.R., Ernst, W. 2016. Distribution, identification, and quantification of residues after treatment of ready-to-eat salami with 36Cl-labeled or nonlabeled chlorine dioxide gas. Journal of Agricultural and Food Chemistry. 64:8454-8462.

Near infrared spectroscopy and aquaphotomics analysis of serum from mares exposed to the fungal mycotoxin zearalenone - (Abstract Only)
Vance, C.K., Counsell, K., Agcanas, L.A., Shappell, N.W., Bowers, S., Willard, S.T., Ryan, P. 2017. Near infrared spectroscopy and aquaphotomics analysis of serum from mares exposed to the fungal mycotoxin zearalenone [abstract]. Reproduction, Fertility and Development. 29(1):160-161.

A novel approach to comparing reproductive stage serum profiles in mares using near infrared spectroscopy (NIR) and aquaphotomics - (Abstract Only)
Agcanas, L.A., Counsell, K., Shappell, N.W., Bowers, S., Ryan, P., Willard, S.T., Vance, C.K. 2017. A novel approach to comparing reproductive stage serum profiles in mares using near infrared spectroscopy (NIR) and aquaphotomics [abstract]. Reproduction, Fertility and Development. 29(1):117.

Detection of residues in urine and tissues of sheep treated with trace levels of dietary ractopamine HCl - (Peer Reviewed Journal)
Smith, D.J., Shelver, W.L., Marx, A. 2016. Detection of residues in urine and tissues of sheep treated with trace levels of dietary ractopamine HCl. Journal of Animal Science. 94:5423–5433. doi:10.2527/jas2016-0899.

Urinary excretion of the ß-adrenergic feed additives ractopamine and zilpaterol in breast and lung cancer patients - (Peer Reviewed Journal)
Cheng, T.D., Shelver, W.L., Hong, C., McCann, S.E., Davis, W., Zhang, Y., Ambrosone, C.B., Smith, D.J. 2016. Urinary excretion of the ß-adrenergic feed additives ractopamine and zilpaterol in breast and lung cancer patients. Journal of Agricultural and Food Chemistry. 64(40):7632-7639.

Missing links in our understanding of estrogenic compounds; chemical quantitation vs. biological assessment – where do we go from here? - (Abstract Only)
Shappell, N.W. 2016. Missing links in our understanding of estrogenic compounds; chemical quantitation vs. biological assessment – where do we go from here? [abstract]. 7th Society of Environmental Toxicology and Chemistry [SETAC World Congress/SETAC North America 37th Annual Meeting, Nov. 6-10th, 2016, Orlando, Florida. Abstract #342. p. 97.