Research Project: Identification of Host Factors and Immunopathogenesis of Pneumonia in Domestic and Bighorn Sheep

Location: Animal Disease Research

Publications (Clicking on the reprint icon will take you to the publication reprint.)

A high-density genome-wide association with absolute blood monocyte count in domestic sheep identifies novel loci - (Peer Reviewed Journal)
Oliveira, R.D., Mousel, M.R., Gonzalez, M.V., Durfee, C.J., Davenport, K.M., Murdoch, B.M., Taylor, J.B., Neibergs, H.L., White, S.N. 2022. A high-density genome-wide association with absolute blood monocyte count in domestic sheep identifies novel loci. PLoS ONE. 17(5). Article e0266748. https://doi.org/10.1371/journal.pone.0266748.

Development of a real-time PCR assay for detection and differentiation of Mycoplasma ovipneumoniae and a novel respiratory-associated Mycoplasma species in domestic sheep and goats - (Peer Reviewed Journal)
Noll, L.W., Highland, M.A., Hamill, V.A., Tsui, W., Porter, E.P., Lu, N., Sebhatu, T., Brown, S., Herndon, D.R., Grossman, P.C., Bai, J. 2022. Development of a real-time PCR assay for detection and differentiation of Mycoplasma ovipneumoniae and a novel respiratory-associated Mycoplasma species in domestic sheep and goats. Transboundary and Emerging Diseases. https://doi.org/10.1111/tbed.14477.

Proteome-wide epitope prediction: Leveraging bioinformatic technologies in rational vaccine design - (Peer Reviewed Journal)
Piel, L.M., White, S.N. 2022. Proteome-wide epitope prediction: Leveraging bioinformatic technologies in rational vaccine design. Cellular Immunology. 3(6):375-379. https://doi.org/10.33696/immunology.3.120.

Laboratory concordance study for the molecular detection of Mycoplasma ovipneumoniae - (Peer Reviewed Journal)
Lieske, C.L., Herndon, D.R., Highland, M.A., Beckmen, K.F. 2022. Laboratory concordance study for the molecular detection of Mycoplasma ovipneumoniae. Journal of Wildlife Diseases. 58(2):257-268. https://doi.org/10.7589/JWD-D-21-00118.

Genes involved in immune, gene translation and chromatin organization pathways associated with Mycoplasma ovipneumoniae presence in nasal secretions of domestic sheep - (Peer Reviewed Journal)
Mousel, M.R., White, S.N., Herndon, M.K., Herndon, D.R., Taylor, J.B., Becker, G.M., Murdoch, B.M. 2021. Genes involved in immune, gene translation and chromatin organization pathways associated with Mycoplasma ovipneumoniae presence in nasal secretions of domestic sheep. PLoS ONE. 16(7). Article e0247209. https://doi.org/10.1371/journal.pone.0247209.

A DNA regulatory element haplotype at zinc finger genes is associated with host resilience to small ruminant lentivirus in two sheep populations - (Peer Reviewed Journal)
Massa, A.T., Mousel, M.R., Durfee, C.J., Herndon, M.K., Hemmerling, K.M., Taylor, J.B., Neibergs, H.L., White, S.N. 2021. A DNA regulatory element haplotype at zinc finger genes is associated with host resilience to small ruminant lentivirus in two sheep populations. Animals. 11(7). Article 1907. https://doi.org/10.3390/ani11071907.

Proteome-wide analysis of Coxiella burnetii for conserved T-cell epitopes with presentation across multiple host species - (Peer Reviewed Journal)
Piel, L.M.W., Durfee, C.J., White, S.N. 2021. Proteome-wide analysis of Coxiella burnetii for conserved T-cell epitopes with presentation across multiple host species. BMC Bioinformatics. 22. Article 296. https://doi.org/10.1186/s12859-021-04181-w.

Characterizing genetic regulatory elements in ovine tissues - (Peer Reviewed Journal)
Davenport, K.M., Massa, A.T., Bhattarai, S., McKay, S.D., Mousel, M.R., Herndon, M.K., White, S.N., Cockett, N.E., Smith, T.P., Murdoch, B.M. 2021. Characterizing genetic regulatory elements in ovine tissues. Frontiers in Genetics. 12. Article 628849. https://doi.org/10.3389/fgene.2021.628849.

Functional variants surrounding endothelin 2 are associated with mycobacterium avium subspecies paratuberculosis infection - (Peer Reviewed Journal)
Kiser, J.N., Wang, Z., Zanella, R., Scraggs, E., Neupane, M., Cantrell, B., Van Tassell, C.P., White, S.N., Talor, J.F., Neibergs, H.L. 2021. Functional variants surrounding endothelin 2 are associated with mycobacterium avium subspecies paratuberculosis infection. Frontiers in Veterinary Science. https://doi.org/10.3389/fvets.2021.625323.

Differential pulmonary immunopathology of domestic sheep (Ovis aries) and bighorn sheep (Ovis canadensis) with Mycoplasma ovipneumoniae infection: a retrospective study - (Peer Reviewed Journal)
Grossman, P.C., Schneider, D.A., Herndon, D.R., Knowles, D.P., Highland, M.A. 2021. Differential pulmonary immunopathology of domestic sheep (Ovis aries) and bighorn sheep (Ovis canadensis) with Mycoplasma ovipneumoniae infection: a retrospective study. Comparative Immunology Microbiology and Infectious Diseases. 76. Article 101641. https://doi.org/10.1016/j.cimid.2021.101641.

Draft genome sequence of a novel Mycoplasma species identified from the respiratory tract of an Alaska moose (Alces alces gigas) - (Peer Reviewed Journal)
Herndon, D.R., Beckmen, K.B., Highland, M.A. 2021. Draft genome sequence of a novel Mycoplasma species identified from the respiratory tract of an Alaska moose (Alces alces gigas). Microbiology Resource Announcements. 10(8). Article e01371- 20. https://doi.org/10.1128/MRA.01371-20.

Natural genetic variation in Drosophila melanogaster reveals genes associated with Coxiella burnetii infection - (Peer Reviewed Journal)
Guzman, R.M., Howard, Z.P., Liu, Z., Oliveira, R.D., Massa, A.T., Omsland, A., White, S.N., Goodman, A.G. 2021. Natural genetic variation in Drosophila melanogaster reveals genes associated with Coxiella burnetii infection. Genetics. 217(3). Article iyab005. https://doi.org/10.1093/genetics/iyab005.

Association of TMEM8B and SPAG8 with mature weight in sheep - (Peer Reviewed Journal)
Cinar, M.U., Mousel, M.R., Herndon, M.K., Taylor, J.B., White, S.N. 2020. Association of TMEM8B and SPAG8 with mature weight in sheep. Animals. 10(12). Article 2391. https://doi.org/10.3390/ani10122391.

Genome-wide histone modifications and CTCF enrichment predict gene expression in sheep macrophages - (Peer Reviewed Journal)
Massa, A.T., Mousel, M.R., Herndon, M.K., Herndon, D.R., Murdoch, B.M., White, S.N. 2021. Genome-wide histone modifications and CTCF enrichment predict gene expression in sheep macrophages. Frontiers in Genetics. 11. Article 612031. https://doi.org/10.3389/fgene.2020.612031.

Assay to compare cell-and antibody-mediated immune responses in domestic sheep and goats - (Peer Reviewed Journal)
Herndon, M.K., White, S.N., Mousel, M.R. 2020. Assay to compare cell-and antibody-mediated immune responses in domestic sheep and goats. Veterinary Immunology and Immunopathology. 230. Article 110125. https://doi.org/10.1016/j.vetimm.2020.110125.

The EDN2 rs110287192 gene polymorphism is associated with paratuberculosis susceptibility in multibreed cattle population - (Peer Reviewed Journal)
Cinar, M.U., Akyüz, B., Arslan, K., White, S.N., Neibergs, H.L., Gümüssoy, K.S. 2020. The EDN2 rs110287192 gene polymorphism is associated with paratuberculosis susceptibility in multibreed cattle population. PLoS ONE. 15(9). Article e0238631. https://doi.org/10.1371/journal.pone.0238631.

Comparison of three methods of enumeration for Mycoplasma ovipneumoniae - (Peer Reviewed Journal)
Ackerman, M., Schneider, D.A., Baker, K.N., Besser, T.E. 2019. Comparison of three methods of enumeration for Mycoplasma ovipneumoniae. Journal of Microbiological Methods. 165. https://doi.org/10.1016/j.mimet.2019.105700.

Mycoplasma ovis infection in domestic sheep (Ovis aries) in the United States: prevalence, distribution, associated risk factors, and associated outcomes - (Peer Reviewed Journal)
Urie, N.J., Highland, M.A., Knowles, D.P., Brannan, M.A., Herndon, D.R., Marshall, K.L. 2019. Mycoplasma ovis infection in domestic sheep (Ovis aries) in the United States: prevalence, distribution, associated risk factors, and associated outcomes. Preventive Veterinary Medicine. 171. https://doi.org/10.1016/j.prevetmed.2019.104750.

Mycoplasma ovipneumoniae associated with polymicrobial pneumonia in a free-ranging yearling caribou (Rangifer tarandus tarandus) from Alaska, USA - (Peer Reviewed Journal)
Rovani, E.R., Beckman, K.B., Highland, M.A. 2019. Mycoplasma ovipneumoniae associated with polymicrobial pneumonia in a free-ranging yearling caribou (Rangifer tarandus tarandus) from Alaska, USA. Journal of Wildlife Diseases. 55(3):733-736. https://doi.org/10.7589/2018-08-188.

Chapter 61: Caprine arthritis-encephalitis - (Book / Chapter)
Murphy, B., Knowles, D., Highland, M.A. 2018. Caprine arthritis-encephalitis. Anipedia-Infectious Diseases of Livestock. Available: https://www.anipedia.org/resources/caprine-arthritis-encephalitis/1027.

Chapter 60: Visna-maedi - (Book / Chapter)
Murphy, B., Knowles, D., Highland, M.A. 2018. Visna-maedi. In: Coetzer, J.A.W., Thomson, G.R., Maclachlan, N.J., Penrith, M.L., editors. Anipedia-Infectious Diseases of Livestock. Anipedia. Available: https://www.anipedia.org/resources/visna-maedi/1035.

Identification of Mycoplasma ovipneumoniae in wildlife species beyond the subfamily caprinae - (Peer Reviewed Journal)
Highland, M.A., Herndon, D.R., Bender, S., Hansen, L., Gerlach, R.F., Beckman, K.B. 2018. Identification of Mycoplasma ovipneumoniae in wildlife species beyond the subfamily caprinae. Emerging Infectious Diseases. 24(12):2384-2386. https://doi.org/10.3201/eid2412.180632.

Tenascin-XB (TNXB) amino acid substitution E2004G is associated with mature weight and milk score in rambouillet, targhee, polypay, and suffolk sheep - (Peer Reviewed Journal)
Cinar, M., Mousel, M.R., Herndon, M.K., Taylor, J.B., White, S.N. 2018. Tenascin-XB (TNXB) amino acid substitution E2004G is associated with mature weight and milk score in rambouillet, targhee, polypay, and suffolk sheep. Small Ruminant Research. 166:129-133. https://doi.org/10.1016/j.smallrumres.2018.06.013.

Complete mitochondrial genome sequence of bighorn sheep - (Peer Reviewed Journal)
Davenport, K.M., Duan, M., Hunter, S.S., New, D.D., Fagnan, M.W., Highland, M.A., Murdoch, B.M. 2018. Complete mitochondrial genome sequence of bighorn sheep. Genome Announcements. https://doi.org/10.1128/genomeA.00464-18.

Passive transfer in domestic and bighorn lambs Total IgG in ewe sera and colostrum and serum IgG kinetics in lambs following colostrum ingestion are similar in domestic sheep and bighorn sheep (ovis aries and ovis canadensis) - (Peer Reviewed Journal)
Highland, M.A., Berglund, A.K., Knowles, D.P. 2018. Total IgG concentrations in ewe sera and colostrum and kinetics in lambs following colostrum ingestion is similar in domestic sheep and bighorn sheep (ovis aries and ovis canadensis). Sheep and Goat Research Journal. 32:36-42.

Identification of genes associated with susceptibility to mycobacterium avium ssp. paratuberculosis (Map) tissue infection in Holstein cattle using gene set enrichment analysis-SNP - (Peer Reviewed Journal)
Kise, J.N., Neupane, M., White, S.N., Neibergs, H.N. 2018. Identification of genes associated with susceptibility to mycobacterium avium ssp. paratuberculosis (Map) tissue infection in Holstein cattle using gene set enrichment analysis-SNP. Mammalian Genome. 29(7-8):539-549. https://doi.org/10.1007/s00335-017-9725-4.

Underdominant KCC3b R31I association with blood sodium concentration in domestic sheep suggests role in oligomer function - (Peer Reviewed Journal)
White, S.N., Oliveira, R.D., Mousel, M.R., Gonzalez, M.V., Highland, M.A., Herndon, M.K., Taylor, J.B., Knowles Jr, D.P. 2017. Underdominant KCC3b R31I association with blood sodium concentration in domestic sheep suggests role in oligomer function. Animal Genetics. 48(5):626-627. https://doi.org/10.1111/age.12585.

Small ruminant lentiviruses: Strain variation, viral tropism, and host genetics influence pathogenesis - (Peer Reviewed Journal)
Highland, M.A. 2017. Small ruminant lentiviruses: Strain variation, viral tropism, and host genetics influence pathogenesis. Veterinary Pathology. 54(3):353-354.