Research Project: Evaluation of Swine Immunity and Development of Novel Immune and Genomic Intervention Strategies to Prevent and/or Treat Respiratory Diseases of Swine

Location: Animal Parasitic Diseases Laboratory

Publications (Clicking on the reprint icon will take you to the publication reprint.)

Genome wide association study of thyroid hormone levels following challenge with porcine reproductive and respiratory syndrome virus - (Peer Reviewed Journal)
Van Goor, A.G., Pasternak, A., Walugembe, M., Chehab, N.L., Hamonic, G., Dekkers, J., Harding, J., Lunney, J.K. 2023. Genome wide association study of thyroid hormone levels following challenge with porcine reproductive and respiratory syndrome virus. Frontiers in Genetics. 14. Article 1110463. https://doi.org/10.3389/fgene.2023.1110463.

Effect of the host genotype at a Porcine Reproductive and Respiratory Syndrome (PRRS) resistance marker on evolution of the modified-live PRRS vaccine virus in pigs - (Peer Reviewed Journal)
Rowland, R.R., Doerksen, T., Lu, A., Sheahan, M., Lunney, J.K., Dekkers, J., Palinski, R.M. 2022. Effect of the host genotype at a Porcine Reproductive and Respiratory Syndrome (PRRS) resistance marker on evolution of the modified-live PRRS vaccine virus in pigs. Virus Research. https://doi.org/10.1016/j.virusres.2022.198809.

Future of biomedical, agricultural and biological systems research using domesticated animals - (Peer Reviewed Journal)
Spencer, T.E., Wells, K.D., Lee, K., Telugu, B.P., Hansen, P.J., Bartol, F.F., Blomberg, L., Schook, L.B., Dawson, H.D., Lunney, J.K., Driver, J.P., Davis, T.A., Donovan, S.M., Dilger, R.N., Saif, L.J., Moeser, A., McGill, J.L., Smith, G., Ireland, J.J. 2022. Future of biomedical, agricultural and biological systems research using domesticated animals. Biology of Reproduction. 106(4):629-638. https://doi.org/10.1093/biolre/ioac019.

Development and characterization of new monoclonal antibodies against porcine Interleukin-17A and Interferon-gamma - (Peer Reviewed Journal)
Manirarora, J., Walker, K.E., Patil, V., Renukaradhya, G., Labresh, J., Sullivan, Y., Francis, O., Lunney, J.K. 2022. Development and characterization of new monoclonal antibodies against porcine Interleukin-17A and Interferon-gamma. Frontiers in Immunology. 13:786396. https://doi.org/10.3389/fimmu.2022.786396.

The natural cytotoxicity receptor NKp44 (NCR2, CD336) is expressed on the majority of porcine NK cells ex vivo without stimulation - (Peer Reviewed Journal)
Mair, K., Crossman, A., Wagner, B., Babsyan, S., Noronha, L., Boyd, P., Zarlenga, D.S., Stadler, M., Von Dongen, K., Gerner, W., Sallmueller, A., Lunney, J.K. 2022. The natural cytotoxicity receptor NKp44 (NCR2, CD336) is expressed on the majority of porcine NK cells ex vivo without stimulation. Frontiers in Immunology. https://doi.org/10.3389/fimmu.2022.767530.

Thyroid dysfunction in feeder pigs following polymicrobial or porcine reproductive and respiratory syndrome virus-2 challenge - (Peer Reviewed Journal)
Pasternak, A., Macphee, D., Lunney, J.K., Rowland, R., Dyck, M., Fortin, F., Dekkers, J., Plastow, G., Harding, J. 2021. Thyroid dysfunction in feeder pigs following polymicrobial or porcine reproductive and respiratory syndrome virus-2 challenge. Journal of Animal Science. 99:(911)1-13. https://doi.org/10.1093/jas/skab325.

Importance of the pig as a human biomedical model: 2020 Update - (Peer Reviewed Journal)

Associations of natural variation in the cd163 and other candidate genes on host response of nursery pigs to PRRSV infection - (Peer Reviewed Journal)
Dong, Q., Dunkelberger, J., Lim, K., Lunney, J.K., Tuggle, C., Rowland, R., Dekkers, J. 2021. Associations of natural variation in the cd163 and other candidate genes on host response of nursery pigs to PRRSV infection. Journal of Animal Science. 1-54. https://doi.org/10.1093/jas/skab274.

Gene expression in tonsils in swine following infection with porcine reproductive and respiratory syndrome virus - (Peer Reviewed Journal)
Dong, Q., Lunney, J.K., Lim, K., Nguyen, Y., Hess, A.S., Beiki, H., Rowland, R., Walker, K.E., Reecy, J., Tuggle, C., Dekkers, J. 2021. Gene expression in tonsils in swine following infection with porcine reproductive and respiratory syndrome virus. BioMed Central (BMC) Veterinary Research. 17:88. https://doi.org/10.1186/s12917-021-02785-1.

Effect of genotype at a genetic marker for the GBP5 gene on resilience to a polymicrobial natural disease challenge in pigs - (Peer Reviewed Journal)
Jeon, R., Cheng, J., Putz, A., Dong, Q., Harding, J., Dyck, M., Plastow, G., Fortin, F., Lunney, J.K., Rowland, R., Dekkers, J. 2021. Effect of genotype at a genetic marker for the GBP5 gene on resilience to a polymicrobial natural disease challenge in pigs. Livestock Science. 244:104399. https://doi.org/10.1016/j.livsci.2021.104399.

Differential responses in placenta and fetal thymus at 12 days post infection elucidate mechanisms of viral level and fetal compromise following PRRSV2 infection - (Peer Reviewed Journal)
Van Goor, A.G., Pasternak, A., Walker, K.E., Hong, L., Malgarin, C., Macphee, D.J., Harding, J.C., Lunney, J.K. 2020. Differential responses in placenta and fetal thymus at 12 days post infection elucidate mechanisms of viral level and fetal compromise following PRRSV2 infection. BMC Genomics. 21:763. https://doi.org/10.1186/s12864-020-07154-0.

Neonatal and infant immunity for vaccine development against tuberculosis: importance of age-matched animal models - (Peer Reviewed Journal)
Ramos, L., Lunney, J.K., Gonzalez-Juarrero, M. 2020. Neonatal and infant immunity for vaccine development against tuberculosis: importance of age-matched animal models. Disease Models and Mechanisms. 13: dmm045740. https://doi.org/10.1242/dmm.045740.

The veterinary immunological toolbox: past, present and future - (Peer Reviewed Journal)
Entrican, G., Lunney, J.K., Wattegedera, S.R., Mwangi, W., Hope, J.C., Hammond, J.A. 2020. The veterinary immunological toolbox: past, present and future. Frontiers in Immunology. 11(1651). https://doi.org/10.3389/fimmu.2020.01651.

Porcine cytokines, chemokines and growth factors: 2019 Update - (Peer Reviewed Journal)
Dawson, H.D., Sang, Y., Lunney, J.K. 2020. Porcine cytokines, chemokines and growth factors: 2019 Update. Research in Veterinary Science. 131:266-300. https://doi.org/10.1016/j.rvsc.2020.04.022.

The NC229 multi-station research consortium on emerging viral diseases of swine: solving stakeholder problems through innovative science and research - (Review Article)
Benfield, D., Lunney, J.K., Murtaugh, M., Nelson, E., Osorio, F., Pogranichniy, R., Ramamoorthy, S., Rowland, R.R., Zimmerman, J.J., Zuckermann, F. 2020. The NC229 multi-station research consortium on emerging viral diseases of swine: solving stakeholder problems through innovative science and research. Virus Research. 280:197898. https://doi.org/10.1016/j.virusres.2020.197898.

Distinguishing fetal and placental immune responses to congenital infection with porcine respiratory and reproductive syndrome virus using NanoString arrays - (Abstract Only)

Importance of the MHC (SLA) in swine health and biomedical research - (Review Article)
Hammer, S.E., Ho, C., Ando, A., Rogel-Gaillard, C., Charles, M., Tector, M., Joseph, T.A., Lunney, J.K. 2020. Importance of the MHC (SLA) in swine health and biomedical research. Review Article. 8:171-198. https://doi.org/10.1146/annurev-animal-020518-115014.

The effects of a globin blocker on the resolution of 3’mRNA sequencing data in porcine blood - (Peer Reviewed Journal)
Kyu-Sang, L., Dong, Q., Moll, P., Vitkovska, J., Wiktorin, G., Bannister, S., Daujotyte, D., Tuggle, C.K., Lunney, J.K., Plastow, G., Dekkers, J. 2019. BMC Genomics. 20:741. https://doi.org/10.1186/s12864-019-6122-2.

Minipigs as neonatal animal model for tuberculosis vaccine efficacy testing - (Peer Reviewed Journal)
Ramos, L., Obregon-Henao, A., Henao-Tamayo, M., Bowen, R., Izzo, A., Lunney, J.K., Gonzalez-Juarrero, M. 2019. Minipigs as neonatal animal model for tuberculosis vaccine efficacy testing. Veterinary Immunology and Immunopathology. 215:109884. https://doi.org/10.1016/j.vetimm.2019.109884.

Genome to Phenome: Improving animal health, production, and well-being: A new USDA blueprint for animal genome research 2018–2027 - (Peer Reviewed Journal)
Rexroad III, C.E., Vallet, J.L., Matukumalli, L.K., Ernst, C., Van Tassell, C.P., Cheng, H.H., Reecy, J., Fulton, J., Taylor, J., Lunney, J.K., Liu, J., Cockett, N., Smith, T.P., Van Eenennaam, A., Clutter, A., Telugu, B., Purcell, C., Bickhart, D.M., Blackburn, H.D., Neibergs, H., Wells, K., Boggess, M.V., Sonstegard, T. 2019. Genome to phenome: improving animal health, production, and well-being: a new USDA blueprint for animal genome research 2018–2027. Frontiers in Genetics. 10:327. https://doi.org/10.3389/fgene.2019.00327.

Annual Progress Report- National Research Support Project- NRSP-8 BARC station report - (Experiment Station)

Genetic relationships of antibody response, viremia level and weight gain in pigs experimentally infected with porcine reproductive and respiratory syndrome virus - (Peer Reviewed Journal)
Hess, A.S., Trible, B., Hess, M.K., Rowland, R., Lunney, J.K., Plastow, G., Dekkers, J. 2018. Genetic relationships of antibody response, viremia level and weight gain in pigs experimentally infected with porcine reproductive and respiratory syndrome virus. Journal of Animal Science. 96:3565-3581. https://doi.org/10.1093/jas/sky229.

Identification of factors associated with virus level in tonsils of pigs experimentally infected with Porcine Reproductive and Respiratory Syndrome virus - (Peer Reviewed Journal)
Hess, A.S., Lunney, J.K., Abrams, S., Choi, I., Trible, B., Hess, M.K., Rowland, R., Plastow, G., Dekkers, J. 2018. Identification of factors associated with virus level in tonsils of pigs experimentally infected with Porcine Reproductive and Respiratory Syndrome virus. Journal of Animal Science. 97:536-547. https://doi.org/10.1093/jas/sky446.

Porcine cluster of differentiation (CD) Markers 2017 Update - (Peer Reviewed Journal)
Dawson, H.D., Lunney, J.K. 2018. Porcine cluster of differentiation (CD) Markers 2017 Update. Research in Veterinary Science. 118:199-246.

The effects of vaccination and WUR genotype on blood gene expression response to co-infection with PRRSV and PCV2 in pigs - (Proceedings)
Dong, Q., Lunney, J.K., Nguyen, Y., Tuggle, C., Reecy, J., Rowland, R.R., Dekkers, J. 2018. The effects of vaccination and WUR genotype on blood gene expression response to co-infection with PRRSV and PCV2 in pigs. World Congress of Genetics Applied in Livestock Production. 11:993.

Alternative strategies for the control and elimination of PRRS - (Review Article)
Rowland, R.R., Lunney, J.K. 2017. Alternative strategies for the control and elimination of PRRS. Veterinary Microbiology. 209:1-4. https://doi.org/10.1016/j.vetmic.2017.09.006.

Immune system - (Book / Chapter)
Chase, C., Lunney, J.K. 2019. Immune System. In:Zimmerman J, Karriker L, Ramirez A, Schwartz K, Stevenson G, Zhang J., editors. Diseases of Swine. 10th edition. Hoboken, New Jersey: John Wiley and Sons, Inc. p. 264-290.

The minipig as an animal model to study Mycobacterium tuberculosis infection and natural transmission - (Peer Reviewed Journal)
Ramos, L., Obregon-Henao, A., Henao-Tamayo, M., Bowen, R., Lunney, J.K., Gonzalez-Juarrero, M. 2017. The minipig as an animal model to study Mycobacterium tuberculosis infection and natural transmission. Tuberculosis. 106:91-98.

Using multi-trait and random regression models to identify genetic variation in tolerance of pigs to Porcine Reproductive and Respiratory Syndrome virus - (Peer Reviewed Journal)
Lough, G., Rashidi, H., Kyriazakis, I., Dekkers, J.C., Hess, A.S., Hess, M.K., Deeb, N., Kause, A., Lunney, J.K., Rowland, R.R., Mulder, H., Doeschl-Wilson, A. 2017. Using multi-trait and random regression models to identify genetic variation in tolerance of pigs to Porcine Reproductive and Respiratory Syndrome virus. Genetics Selection Evolution. 49:37.

Novel insights into host responses and the reproductive pathophysiology of type 2 porcine reproductive and respiratory syndrome (PRRS) - (Review Article)
Harding, J., Ladininig, A., Novakovic, P., Detmer, S., Wilkinson, J., Yang, T., Lunney, J.K., Plastow, G. 2017. Novel insights into host responses and the reproductive pathophysiology of type 2 porcine reproductive and respiratory syndrome (PRRS). Veterinary Microbiology. 209: 114-123. 10.1016/j.vetmic.2017.02.019.