Research Project: Identification of Disease Mechanisms and Control Strategies for Viral Respiratory Pathogens of Ruminants

Location: Ruminant Diseases and Immunology Research

Publications (Clicking on the reprint icon will take you to the publication reprint.)

Genome sequence and experimental infection of calves with bovine gammaherpesvirus 4 (BoHV-4) - (Peer Reviewed Journal)
Bauemann, F.V., Falkenberg, S.M., Martins, M., Dassanayake, R.P., Neill, J.D., Ridpath, J.F., Silveria, S., Palmer, M., Buysse, A., Mohr, A., Flores, E., Diel, D. 2022. Genome sequence and experimental infection of calves with bovine gammaherpesvirus 4 (BoHV-4). Journal of General Virology. 167(8):1659-1668. https://doi.org/10.1007/s00705-022-05486-8.

Virome Characterization in Commercial Bovine Serum Batches—A Potentially Needed Testing Strategy for Biological Products - (Peer Reviewed Journal)
Falkenberg, S.M., Paim, W.P., Maggioli, M.F., Ramachandran, A., Weber, M.N., Canal, C.W., Bauermann, F.V. 2021. Virome Characterization in Commercial Bovine Serum Batches—A Potentially Needed Testing Strategy for Biological Products. Transboundary and Emerging Diseases. 13(12). Article 2425. https://doi.org/10.3390/v13122425.

Use of multivariate analysis to evaluate antigenic relationships between US BVDV vaccine strains and non-US genetically divergent isolates - (Peer Reviewed Journal)
Mosena, A.S., Falkenberg, S.M., Ma, H., Casas, E., Dassanayake, R.P., Booth, R., De Mia, G., Schweizer, M., Canal, C., Neill, J.D. 2021. Use of multivariate analysis to evaluate antigenic relationships between US BVDV vaccine strains and non-US genetically divergent isolates. Journal of Virological Methods. 299. Article 114328. https://doi.org/10.1016/j.jviromet.2021.114328.

Protection against Mycoplasma bovis infection in calves following intranasal vaccination with modified-live Mannheimia haemolytica expressing Mycoplasma antigens - (Peer Reviewed Journal)
Briggs, R.E., Billing, S.R., Boatwright Jr, W.D., Chriswell, B.O., Casas, E., Dassanayake, R.P., Palmer, M.V., Register, K.B., Tatum, F.M. 2021. Protection against Mycoplasma bovis infection in calves following intranasal vaccination with modified-live Mannheimia haemolytica expressing Mycoplasma antigens. Microbial Pathogenesis. 161. Article 105159. https://doi.org/10.1016/j.micpath.2021.105159.

Bovine viral diarrhea virus in cattle from Mexico: current status - (Peer Reviewed Journal)
Ridpath, J., Gomez-Romero, N., Verdugo-Rodriguez, A., Basurto-Alcantara, F.J. 2021. Bovine viral diarrhea virus in cattle from Mexico: current status. Frontiers in Veterinary Science. 8. Article 673577. https://doi.org/10.3389/fvets.2021.673577.

Evaluation of antigenic comparisons among BVDV isolates as it relates to humoral and cell mediated immunological measures - (Peer Reviewed Journal)
Falkenberg, S.M., Dassanayake, R.P., Terhaar, B., Ridpath, J., Neill, J.D., Roth, J. 2021. Evaluation of antigenic comparisons among BVDV isolates as it relates to humoral and cell mediated immunological measures. Frontiers in Veterinary Science. 8. Article 685114. https://doi.org/10.3389/fvets.2021.685114.

Experimental innoculation of young calves with SARS-CoV-2 - (Peer Reviewed Journal)
Falkenberg, S.M., Buckley, A.C., Laverack, M., Martins, M., Palmer, M.V., Diel, D., Lager, K.M. 2021. Experimental innoculation of young calves with SARS-CoV-2. Viruses. 13(3). Article 441. https://doi.org/10.3390/v13030441.

Virus strain influenced the interspecies transmission of influenza D virus between calves and pigs - (Peer Reviewed Journal)
Kaplan, B.S., Falkenberg, S.M., Dassanayake, R.P., Neill, J.D., Velayudhan, B., Li, F., Vincent, A.L. 2020. Virus strain influenced the interspecies transmission of influenza D virus between calves and pigs. Transboundary and Emerging Diseases. https://doi.org/10.1111/tbed.13943.

Changes in circulating lymphocytes and lymphoid tissue associated with vaccination of colostrum deprived calves - (Peer Reviewed Journal)
Falkenberg, S.M., Dassanayake, R.P., Palmer, M.V., Silveria, S., Roth, J.A., Gauger, E., Kaiser, T., Guidarini, C., Neill, J.D., Ridpath, J. 2020. Changes in circulating lymphocytes and lymphoid tissue associated with vaccination of colostrum deprived calves. Vaccine. 38(46):7268-7277. https://doi.org/10.1016/j.vaccine.2020.09.046.

Expression of viral microRNAs in serum and white blood cells of cows exposed to bovine leukemia virus - (Peer Reviewed Journal)
Casas, E., Ma, H., Lippolis, J.D. 2020. Expression of viral microRNAs in serum and white blood cells of cows exposed to bovine leukemia virus. Frontiers in Veterinary Science. 7. Article 536390. https://doi.org/10.3389/fvets.2020.536390.

Multivariate analysis as a method to evaluate antigenic relationships between BVDV vaccine and field strains - (Peer Reviewed Journal)
Mosena, A.C., Falkenberg, S.M., Ma, H., Casas, E., Dassanayake, R.P., Watz, P., Canal, C., Neill, J.D. 2020. Multivariate analysis as a method to evaluate antigenic relationships between BVDV vaccine and field strains. Vaccine. 38(36):5764-5772. https://doi.org/10.1016/j.vaccine.2020.07.010.

Bovine viral diarrhea virus: an updated ACVIM consensus statement with focus on virus biology, hosts, immunosuppression, and vaccination - (Review Article)
Walz, P.H., Chamorro, M.F., Falkenberg, S.M., Passler, T., Van Der Meer, F., Woolums, A. 2020. Bovine viral diarrhea virus: an updated ACVIM consensus statement with focus on virus biology, hosts, immunosuppression, and vaccination. Journal of Veterinary Internal Medicine. 34(5):1690-1706. https://doi.org/10.1111/jvim.15816.

Changes introduced in the open reading frame of bovine viral diarrhea virus during serial infection of pregnant swine - (Peer Reviewed Journal)
Kuca, T., Passler, T., Newcomer, B.W., Neill, J.D., Galik, P.K., Riddell, K.P., Zhang, Y., Bayles, D.O., Walz, P.H. 2020. Changes introduced in the open reading frame of bovine viral diarrhea virus during serial infection of pregnant swine. Frontiers in Microbiology. 11:1138. https://doi.org/10.3389/fmicb.2020.01138.

The immunology of bovine respiratory disease: recent advancements - (Peer Reviewed Journal)
McGill, J.L., Sacco, R.E. 2020. The immunology of bovine respiratory disease: recent advancements. Veterinary Clinics of North America. 36(2):333-348. https://doi.org/10.1016/j.cvfa.2020.03.002.

Measuring CMI responses using the PrimeFlow RNA assay; a new method of evaluating BVDV vaccination response in cattle - (Peer Reviewed Journal)
Falkenberg, S.M., Dassanayake, R.P., Neill, J.D., Walz, P., Casas, E., Ridpath, J.F., Roth, J. 2020. Measuring CMI responses using the PrimeFlow RNA assay; a new method of evaluating BVDV vaccination response in cattle. Veterinary Immunology and Immunopathology. 221:110024. https://doi.org/10.1016/j.vetimm.2020.110024.

Vitamin A deficiency impairs the immune response to intranasal vaccination and RSV infection in neonatal calves - (Peer Reviewed Journal)
McGill, J.L., Kelly, S.M., Guerra-Maupome, M., Winkley, E., Henningson, J., Narasimhan, B., Sacco, R.E. 2019. Vitamin A deficiency impairs the immune response to intranasal vaccination and RSV infection in neonatal calves. Scientific Reports. 9(15157). https://doi.org/10.1038/s41598-019-51684-x.

Oxidative stress pathway gene transcription after bovine respiratory syncytial virus infection in vitro and in vivo - (Peer Reviewed Journal)
Hofstetter, A.R., Sacco, R.E. 2019. Oxidative stress pathway gene transcription after bovine respiratory syncytial virus infection in vitro and in vivo. Veterinary Immunology and Immunopathology. 219(2020):109956. https://doi.org/10.1016/j.vetimm.2019.109956.

In vitro method to evaluate virus competition between BVDV-1 and BVDV-2 strains using the PrimeFlow RNA assay - (Peer Reviewed Journal)
Silveria, S., Falkenberg, S.M., Dassanayake, R.P., Walz, P.H., Ridpath, J.F., Canal, C.W., Neill, J.D. 2019. In vitro method to evaluate virus competition between BVDV-1 and BVDV-2 strains using the PrimeFlow RNA assay. Virology. 536:101-109. https://doi.org/10.1016/j.virol.2019.07.029.

Genomic and antigenic characterization of a cytopathic bovine viral diarrhea virus 1i isolated in the United States - (Peer Reviewed Journal)
Neill, J.D., Crossley, B.M., Mosena, A.C., Ridpath, J.F., Bayles, D.O., Killian, M.L., Falkenberg, S.M. 2019. Genomic and antigenic characterization of a cytopathic bovine viral diarrhea virus 1i isolated in the United States. Virology. 535:279-282. https://doi.org/10.1016/j.virol.2019.07.020.

A serosurvey for bovine Influenza D virus exposure from cattle in the United States, 2014-2015 - (Peer Reviewed Journal)
Silveira, S., Falkenberg, S.M., Kaplan, B.S., Crossley, B., Ridpath, J.F., Bauermann, F.B., Fossler, C.P., Dargatz, D.A., Dassanayake, R.P., Vincent, A.L., Canal, C.W., Neill, J.D. 2019. Serosurvey for influenza D virus exposure in cattle, United States, 2014-2015. Emerging Infectious Diseases. 25(11). https://doi.org/10.3201/eid2511.1902532.

Bovine respiratory syncytial virus infection - (Book / Chapter)
McGill, J.L., Sacco, R.E. 2019. Chapter 52: bovine respiratory syncytial virus infection. In: Coetzer, J.A.W., Thomson, G.R., Maclachaln, N.J., Penrith, M.L., editors. Infectious Diseases of Livestock. Africa. Anipedia. Part 2.

Utility of the neonatal calf model for testing vaccines and intervention strategies for use against human RSV infection - (Peer Reviewed Journal)
Guerra-Maupome, M., Palmer, M.V., McGill, J.L., Sacco, R.E. 2019. Utility of the neonatal calf model for testing vaccines and intervention strategies for use against human RSV infection. Vaccines. 7(1):7. https://doi.org/10.3390/vaccines7010007.

Identification of BVDV2b and 2c subgenotypes in the United States: genetic and antigenic characterization - (Peer Reviewed Journal)
Neill, J.D., Workman, A.M., Hesse, R., Bai, J., Poulsen-Porter, E., Meadors, B., Anderson, J., Bayles, D.O., Falkenberg, S.M. 2019. Identification of BVDV2b and 2c subgenotypes in the United States: genetic and antigenic characterization. Virology. 528:19-29. https://doi.org/10.1016/j.virol.2018.12.002.

Resistance of colostrum-deprived domestic lambs to infection with deer adenovirus - (Peer Reviewed Journal)
Imus, J.K., Lehmkuhl, H.D., Woods, L.W. 2018. Resistance of colostrum-deprived domestic lambs to infection with deer adenovirus. Journal of Veterinary Diagnostic Investigation. 31(1):78-82. https://doi.org/10.1177/1040638718817508.

Frequency of bovine viral diarrhea virus detected in subpopulations of peripheral blood mononuclear cells in persistently infected animals and health outcome - (Peer Reviewed Journal)
Falkenberg, S.M., Dassanayake, R.P., Walz, P., Casas, E., Neill, J.D., Ridpath, J.F. 2019. Frequency of bovine viral diarrhea virus detected in subpopulations of peripheral blood mononuclear cells in persistently infected animals and health outcome. Veterinary Immunology and Immunopathology. 207:46-52. https://doi.org/10.1016/j.vetimm.2018.11.015.

Analysis of tRNA halves (tsRNAs) in serum from cattle challenged with bovine viral diarrhea virus - (Peer Reviewed Journal)
Taxis, T.M., Bauermann, F.V., Ridpath, J.F., Casas, E. 2019. Analysis of tRNA halves (tsRNAs) in serum from cattle challenged with bovine viral diarrhea virus. Genetics and Molecular Biology. 42(2). https://dx.doi.org/10.1590/1678-4685-GMB-2018-0019.

Experimental infection of calves with bovine gammaherpesvirus 4 - (Abstract Only)

Distribution of atypical porcine pestivirus in the cerebellum of newborn piglets following in utero inoculation - (Abstract Only)

Association of transfer RNA fragments in white blood cells with antibody response to bovine leukemia virus in Holstein cattle - (Peer Reviewed Journal)
Taxis, T.M., Kehrli Jr., M.E., D'Orey-Branco, R., Casas, E. 2018. Association of transfer RNA fragments in white blood cells with antibody response to bovine leukemia virus in Holstein cattle. Frontiers in Genetics. 9:236. https://doi.org/10.3389/fgene.2018.00236.

Identification of conserved amino acid substitutions during serial infection of pregnant cattle and sheep with bovine viral diarrhea virus - (Peer Reviewed Journal)
Kuca, T., Passler, T., Newcomer, B.W., Neill, J.D., Galik, P., Riddell, K.P., Zhang, Y., Walz, P.H. 2018. Identification of conserved amino acid substitutions during serial infection of pregnant cattle and sheep with bovine viral diarrhea virus. Frontiers in Microbiology. 9:1109. https://doi.org/10.3389/fmicb.2018.01109.

Identification of a DRB3*1101-restricted CD4 T cell response against bovine respiratory syncytial virus - (Abstract Only)

Immunomediator expression profiling in two beluga whale (delphinapterus leucas) clinical cases - (Abstract Only)

Serological survey for antibodies against pestiviruses in Wyoming domestic sheep - (Peer Reviewed Journal)
Silveira, S., Falkenberg, S.M., Elderbrook, M.J., Sondgeroth, K.S., Dassanayake, R.P., Neill, J.D., Ridpath, J.F., Canal, C.W. 2018. Serological survey for antibodies against pestiviruses in Wyoming domestic sheep. Veterinary Microbiology. 219:96-99. https://doi.org/10.1016/j.vetmic.2018.04.019.

Comparison of reproductive protection against bovine viral diarrhea virus provided by multivalent viral vaccines containing inactivated fractions of bovine viral diarrhea virus 1 and 2 - (Peer Reviewed Journal)
Walz, P.H., Riddell, K.P., Newcomer, B.W., Neill, J.D., Falkenberg, S.M., Cortese, V.S., Scruggs, D.W., Short, T.H. 2018. Comparison of reproductive protection against bovine viral diarrhea virus provided by multivalent viral vaccines containing inactivated fractions of bovine viral diarrhea virus 1 and 2. Vaccine. 36(26):3853-3860. https://doi.org/10.1016/j.vaccine.2018.04.005.

Relationship between viral shedding in the transmission of bovine viral diarrhea virus to naïve calves by direct and indirect exposure routes - (Peer Reviewed Journal)
Falkenberg, S.M., Dassanayake, R.P., Neill, J.D., Ridpath, J.F. 2018. Evaluation of bovine viral diarrhea virus transmission potential to naïve calves by direct and indirect exposure routes. Veterinary Microbiology. 217:144-148. https://doi.org/10.1016/j.vetmic.2018.03.012.

Sequential exposure to bovine viral diarrhea virus and bovine coronavirus results in increased respiratory disease lesions: clinical, immunologic, pathologic, and immunohistochemical findings - (Peer Reviewed Journal)
Ridpath, J., Fulton, R.W., Bauermann, F.V., Falkenberg, S.M., Welch, J., Confer, A.W. 2020. Sequential exposure to bovine viral diarrhea virus and bovine coronavirus results in increased respiratory disease lesions: clinical, immunologic, pathologic, and immunohistochemical findings. Journal of Veterinary Diagnostic Investigation. 32(4):513-526. https://doi.org/10.1177/1040638720918561.

Development and testing of species-specific ELISA assays to measure IFN-gamma and TNF-alpha in bottlenose dolphins (Tursiops truncatus) - (Peer Reviewed Journal)
Eberle, K.C., Venn-Watson, S.K., Jensen, E.D., Labresh, J., Sullivan, Y., Kakach, L., Sacco, R.E. 2018. Development and testing of species-specific ELISA assays to measure IFN-gamma and TNF-alpha in bottlenose dolphins (Tursiops truncatus). PLoS One. 13(1):e0190786. https://doi.org/10.1371/journal.pone.0190786.

Feed intake and weight changes in Bos indicus-Bos taurus crossbred steers following Bovine Viral Diarrhea Virus Type 1b challenge under production conditions - (Peer Reviewed Journal)
Runyan, C.A., Downey-Slinker, E.D., Ridpath, J.F., Hairgrove, T.B., Sawyer, J.E., Herring, A.D. 2017. Feed intake and weight changes in Bos indicus-Bos taurus crossbred steers following Bovine Viral Diarrhea Virus Type 1b challenge under production conditions. Pathogens. 6(4):66. https://doi.org/10.3390/pathogens6040066.

Longitudinal monitoring of bottlenose dolphins leukocyte cytokine mRNA responsiveness by qPCR - (Abstract Only)

Efficacy of a mucosal, polyanhydride nanovaccine for use against respiratory syncytial virus infection in the neonatal calf - (Peer Reviewed Journal)
McGill, J.L., Kelly, S.M., Kumar, P., Speckhart, S., Haughney, S.L., Henningson, J., Narasimhan, B., Sacco, R.E. 2018. Efficacy of mucosal, polyanhydride nanovaccine against respiratory syncytial virus infection in the neonatal calf. Nature Scientific Reports. 8(1):3021. https://doi.org/10.1038/s41598-018-21292-2.

Monitoring bottlenose dolphin leukocyte cytokine mRNA responsiveness by qPCR - (Peer Reviewed Journal)
Hofstetter, A.R., Eberle, K.C., Venn-Watson, S.K., Jensen, E.D., Porter, T.J., Waters, T.E., Sacco, R.E. 2017. Monitoring bottlenose dolphin leukocyte cytokine mRNA responsiveness by qPCR. PLoS One. 12(12):e0189437. https://doi.org/10.1371/journal.pone.0189437.

Identification of monoclonal antibodies cross-reactive with bottlenose dolphin orthologues of the major histocompatibility complex and leukocyte differentiation molecules - (Peer Reviewed Journal)
Elnaggar, M.M., Abdellrazeq, G.S., Venn-Watson, S.K., Jensen, E.D., Mack, V., Fry, L.M., Sacco, R.E., Davis, W.C. 2017. Identification of monoclonal antibodies cross-reactive with bottlenose dolphin orthologues of the major histocompatibility complex and leukocyte differentiation molecules. Developmental and Comparative Immunology. 192:54-59. https://doi.org/10.1016/j.vetimm.2017.09.007.

Longitudinal monitoring of bottlenose dolphin leukocyte cytokine mRNA responsiveness by qPCR - (Abstract Only)

Clinical report: Detection and management of bovine viral diarrhea virus Type 1b in a large dairy herd - (Peer Reviewed Journal)
Cox, E.A., Ridpath, J.F., Falkenberg, S.M. 2017. Clinical report: Detection and management of bovine viral diarrhea virus Type 1b in a large dairy herd. Bovine Practitioner Journal. 51(2):153-156.

Improved detection of Bovine Viral Diarrhea Virus in Bovine lymphoid cell lines using PrimeFlow RNA assay - (Peer Reviewed Journal)
Falkenberg, S.M., Dassanayake, R.P., Silveira, S., Neill, J.D., Ridpath, J.F. 2017. Improved detection of Bovine Viral Diarrhea Virus in Bovine lymphoid cell lines using PrimeFlow RNA assay. American Association of Veterinary Laboratory Diagnosticians. 235:77-81. 10.1016/j.virol.2017.06.032.

Serological survey for antibodies against pestiviruses in sheep in Wyoming - (Abstract Only)

Demonstration of systemic infection of BVDV Vaccine virus after vaccination in presence of PI calves - (Abstract Only)

Improved detection of bovine viral diarrhea virus in bovine lymphoid cell lines using PrimeFlow RNA assay - (Peer Reviewed Journal)
Falkenberg, S.M., Dassanayake, R.P., Neill, J.D., Ridpath, J.F. 2017. Improved detection of bovine viral diarrhea virus in bovine lymphoid cell lines using PrimeFlow RNA assay. Virology. 509(2017):260-265. doi. 10.1016/j.virol.2017.06.032.

Isolation and characterization of a novel cervid adenovirus from white-tailed deer (Odocoileus virginianus) fawns in a captive herd - (Peer Reviewed Journal)
Ridpath, J.F., Neill, J.D., Palmer, M.V., Bauermann, F.V., Falkenberg, S.M., Wolff, P.L. 2017. Isolation and characterization of a novel cervid adenovirus from white-tailed deer (Odocoileus virginianus) fawns in a captive herd. Virus Research. 238:198-203. doi: 10.1016/j.virusres.2017.06.020.

MicroRNA expression and implications for infectious diseases in livestock - (Peer Reviewed Journal)
Taxis, T.M., Casas, E. 2017. MicroRNA expression and implications for infectious diseases in livestock. Centre for Agriculture and Biosciences International. 12(26):1-20. https://doi.org/10.1079/PAVSNNR201712026.

Circulating microRNAs in serum from cattle challenged with Bovine Viral Diarrhea Virus - (Peer Reviewed Journal)
Taxis, T.M., Bauermann, F.V., Ridpath, J.F., Casas, E. 2017. Circulating microRNAs in serum from cattle challenged with Bovine Viral Diarrhea Virus. Frontiers in Genetics. doi.org/10.3389/fgene.2017.00091.

NADPH oxidases (NOXes) and reactive oxygen in viral infections, with emphasis on influenza - (Book / Chapter)

Development of specific cytokine and Chemokine ELISAs for Bottlenose Dolphins - (Abstract Only)