Research Project: Effect of Resistant Starch and Cruciferous Vegetables on Mucosal Immunity and Disease Resistance

Location: Diet, Genomics and Immunology Laboratory

Publications (Clicking on the reprint icon will take you to the publication reprint.)

A type 4 resistant potato starch alters the cecal microbiome and gene expression in mice fed a Western diet based on NHANES data - (Peer Reviewed Journal)
Smith, A.D., Chen, C.T., Cheung, L., Ward, R., Jones, B., Pletsch, E.A., Dawson, H.D. 2024. A type 4 resistant potato starch alters the cecal microbiome and gene expression in mice fed a Western diet based on NHANES data. Nutrients. 15:3141-3157. https://doi.org/10.1039/d3fo04512a.

Raw potato starch alters the microbiome, colon and cecal gene expression, and resistance to citrobacter rodentium infection in mice fed a western diet - (Peer Reviewed Journal)
Smith, A.D., Chen, C.T., Cheung, L., Dawson, H.D. 2023. Raw potato starch alters the microbiome, colon and cecal gene expression, and resistance to citrobacter rodentium infection in mice fed a western diet. Frontiers in Nutrition. 9:2022. https://doi.org//10.3389/fnut.2022.1057318.

Immunologic and pathologic characterization of a novel swine biomedical research model for eosinophilic esophagitis - (Peer Reviewed Journal)
Cortesa, L.M., Brodsky, D., Chen, C.T., Pridgen, T., Odle, J., Snyder, D., Cruse, G., Putikova, A., Masuda, M.Y., Doyle, A.D., Wright, B.L., Dawson, H.D., Blikslager, A., Dellon, E.S., Laster, S.M., Kaser, T. 2022. Immunologic and pathologic characterization of a novel swine biomedical research model for eosinophilic esophagitis. Frontiers in Allergy. 3:2022. https://doi.org//10.3389/falgy.2022.1029184.

Resistant potato starch alters the cecal microbiome and gene expression in mice fed a Western diet based on NHANES data - (Peer Reviewed Journal)
Smith, A.D., Chen, C.T., Cheung, L., Ward, R., Hintze, K., Dawson, H.D. 2022. Resistant potato starch alters the cecal microbiome and gene expression in mice fed a Western diet based on NHANES data. Frontiers in Nutrition. 9. Article 782667. https://doi.org/10.3389/fnut.2022.782667.

IL-25 treatment improves metabolic syndrome in high fat diet and genetic models of obesity - (Peer Reviewed Journal)
Smith, A.D., Fan, A.X., Qin, B., Desai, N., Zhao, A., Shea-Donohue, T. 2021. IL-25 treatment improves metabolic syndrome in high-fat diet and genetic models of obesity. Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy. 14:4875-4887. https://doi.org/10.2147/DMSO.S335761.

Up-regulation of gasdermin C in mouse small intestine is associated with lytic cell death in enterocytes in worm-induced type 2 immunity - (Peer Reviewed Journal)
Xi, R., Montague, J., Lin, X., Lu, C., Lei, W., Tanaka, K., Zhang, Y., Xu, X., Zheng, X., Zhou, X., Urban Jr, J.F., Iwatsuki, K., Margolskee, R.F., Matsumoto, I., Tizzano, M., Li, J., Jiang, P. 2021. Up-regulation of gasdermin C in mouse small intestine is associated with lytic cell death in enterocytes in worm-induced type 2 immunity. Proceedings of the National Academy of Sciences (PNAS). 118(30). Article e2026307118. https://doi.org/10.1073/pnas.2026307118.

Interleukin-33 promotes seratonin release from enterochromaffin cells for intestional homeostasis - (Peer Reviewed Journal)
Chen, Z., Luo, J., Li, J., Kim, G., Stewart, A., Urban Jr, J.F., Huang, Y., Chen, S., Wu, L., Chester, A., Trinchieri, G., Li, W., Wu, C. 2020. Interleukin-33 promotes seratonin release from enterochromaffin cells for intestional homeostasis. Immunity. 54(1):151-163.e6. https://doi.org/doi:10.1016/j.immuni.2020.10.014.

Potentiation of IL-4 signaling by retinoic acid in intestinal epithelial cells and macrophages - mechanisms and targets - (Peer Reviewed Journal)
Chen, C.T., Smith, A.D., Cheung, L., Pham, Q., Urban Jr, J.F., Dawson, H.D. 2020. Potentiation of IL-4 signaling by retinoic acid in intestinal epithelial cells and macrophages - mechanisms and targets. Frontiers in Immunology. 10.3389. https://doi.org/10.3389/fimmu.2020.00605.