Research Project: Discovery and Development of Natural Product-Based Pesticides and Pharmaceuticals

Location: Natural Products Utilization Research

Publications (Clicking on the reprint icon will take you to the publication reprint.)

Curcuma longa essential oils:toxicity and repellency against hybrid imported fire ants (Formicidae: Hymenoptera) - (Peer Reviewed Journal)
Ali A, Shah FM, Radwan MM, Elhendawy MA, Elsohly MA, Khan IA. Curcuma longa essential oils: toxicity and repellency against imported fire ants (Formicidae: Hymenoptera). J Med Entomol. 2024 Jan 12;61(1):191-200. doi:https://doi.org/10.1093/jme/tjad151

Matricaria chamomilla Essential Oils: Repellency and Toxicity against Imported Fire Ants (Hymenoptera: Formicidae) - (Peer Reviewed Journal)
Shah, F.M.; Guddeti, D.K.; Paudel, P.; Chen, J.; Li, X.-C.; Khan, I.A.; Ali, A. Matricaria chamomilla Essential Oils: Repellency and Toxicity against Imported Fire Ants (Hymenoptera: Formicidae). Molecules 2023, 28, 5584. https://doi.org/10.3390/molecules28145584

Identification of botanicals that unmask beta-glucan from the cell surface of an opportunistic fungal pathogen - (Peer Reviewed Journal)
Zhang, J., Agarwal, A., Feng, Q., Tripathi, S.K., Khan, I.A., Pugh, N.D. 2023. Identification of botanicals that unmask beta-glucan from the cell surface of an opportunistic fungal pathogen. Journal of Dietary Supplement. https://doi.org/10.1080/19390211.2023.2201355.

Juniper berry (Juniperus communis L.) extract regulates obesity markers through modulating PPAR-alpha, PPAR-gamma, and LXR: in vitro and in vivo effects - (Peer Reviewed Journal)
Chae, H., Dale, O., Mir, T.M., Ashfaq, M.K., Avula, B., Walker, L.A., Khan, I.A., Khan, S.I. 2023. Juniper berry (Juniperus communis L.) extract regulates obesity markers through modulating PPAR-alpha, PPAR-gamma, and LXR: in vitro and in vivo effects. Journal of Medicinal Food. https://doi.org/10.1089/jmf.2022.0146.

In vitro and in silico studies of neolignans from Magnolia Grandiflora L. seeds against human cannabinoid and opioid receptors - (Peer Reviewed Journal)
Pandey, P., Kumarihamy, M., Ibrahim, M.A., Ilias, M., Doerksen, R.J. 2023. In vitro and in silico studies of neolignans from Magnolia Grandiflora L. seeds against human cannabinoid and opioid receptors. Molecules. https://doi.org/10.3390/molecules28031253.

Natural product-based crop protection compounds - origins and future prospects - (Peer Reviewed Journal)
Sparks, T.C., Sparks, J.M., Duke, S.O. 2023. Natural product-based crop protection compounds - origins and future prospects. Journal of Agricultural and Food Chemistry. https://doi.org/10.1021/acs.jafc.2c06938.

Advances in the chemistry, analysis, and adulteration of anthocyanin rich-berries and fruits: 2000-2022 - (Peer Reviewed Journal)
Avula, B., Katragunta, K., Osman, A.G., Ali, Z., Adams, S., Chittiboyina, A.G., Khan, I.A. 2023. Advances in the chemistry, analysis, and adulteration of anthocyanin rich-berries and fruits: 2000-2022. Molecules. https://doi.org/10.3390/molecules28020560.

Phytochemical investigation of Teucrium pruinosum and biological potential assessment of the isolated diterpenoids - (Peer Reviewed Journal)
Aydogan, F., Boga, M., Khan, S.I., Zulfiqar, F., Khan, I.A., Ali, Z. 2022. Phytochemical investigation of Teucrium pruinosum and biological potential assessment of the isolated diterpenoids. Biochemical Systematics and Ecology, Volume 105, 2022, 104545, https://doi.org/10.1016/j.bse.2022.104545.

Bioassay-guided isolation of iridoid glucosides from Stenaria nigricans, their biting deterrence against aedes aegypti (Diptera: Culicidae) and repellency potential against imported fire ants (Hymenoptera: Formicidae) - (Peer Reviewed Journal)
Zulfiqar, F., Ali, A., Ali, Z., Khan, I.A. 2022. Bioassay-guided isolation of iridoid glucosides from Stenaria nigricans, their biting deterrence against aedes aegypti (Diptera: Culicidae) and repellency potential against imported fire ants (Hymenoptera: Formicidae). Molecules. https://doi.org/10.3390/molecules27207053.

Screening of medicinal plants for possible herb-drug interactions through modulating nuclear receptors, drug-metabolizing enzymes and transporters - (Peer Reviewed Journal)
Husain, I., Dale, O.R., Martin, K., Gurley, B.J., Avula, B., Chittiboyina, A.G., Khan, I.A., Khan, S.I. 2022. Screening of medicinal plants for possible herb-drug interactions through modulating nuclear receptors, drug-metabolizing enzymes and transporters. Journal of Ethnopharmacology. https://doi.org/10.1016/j.jep.2022.115822.

Stepping beyond hormesis modelling and sub-NOAEL predictions in plant biology - (Peer Reviewed Journal)
Duke, S.O., Belz, R.G. 2022. Stepping beyond hormesis modelling and sub-NOAEL predictions in plant biology. Current Opinion in Environmental Science & Health. https://doi.org/10.1016/j.coesh.2022.100366.

Simultaneous determination and characterization of flavonoids, sesquiterpene lactone, and other phenolics from centaurea benedicta and dietary dupplements using UHPLC-PDA-MS and LC-DAD-QToF - (Peer Reviewed Journal)
Avula, B., Katragunta, K., Wang, Y., Ali, Z., Khan, I.A. 2022. Simultaneous determination and characterization of flavonoids, sesquiterpene lactone, and other phenolics from centaurea benedicta and dietary dupplements using UHPLC-PDA-MS and LC-DAD-QToF. Journal of Pharmaceutical and Biomedical Analysis. https://doi.org/10.1016/j.jpba.2022.114806.

A novel cyclohexane carboxylic acid derivative from Black Turtle Bean (Phaseolus vulgaris L.) - (Peer Reviewed Journal)
Balkisu, A., Fadime, A., Zulfiqar, F., Zhao, J., Khan, I. 2022. A novel cyclohexane carboxylic acid derivative from Black Turtle Bean (Phaseolus vulgaris L.). Records of Natural Products. http://doi.org/10.25135/rnp.325.2202.2361.

Chemical profiling and UHPLC-QToF analysis for the simultaneous determination of anthocyanins and flavonoids in Sambucus berries and authentication and detection of adulteration... - (Peer Reviewed Journal)
Avula, B., Katragunta, K., Wang, Y., Ali, Z., Srivedavyasasri, R., Gafner, S., Slimestad, R., Khan, I.A. 2022. Chemical profiling and UHPLC-QToF analysis for the simultaneous determination of anthocyanins and flavonoids in Sambucus berries and authentication and detection of adulteration in elderberry dietary supplements using UHPLC-PDA-MS. Journal of Pharmaceutical and Biomedical Analysis. https://doi.org/10.1016/j.jfca.2022.104584.

Analysis of Crocetins and Saffanal variations in Saffron(Crocus sativus) stigma samples and dietary supplements using HPLC-UHPLC-PDA-MS: Chemical profiling and chemometric analysis using LC-QToF - (Peer Reviewed Journal)
Avula, B., Katragunta, K., Wang, Y., Upton, R., Khan, I.A. 2022. Analysis of Crocetins and Saffanal variations in Saffron(Crocus sativus) stigma samples and dietary supplements using HPLC-UHPLC-PDA-MS: Chemical profiling and chemometric analysis using LC-QToF. Food Analytical Methods. https://doi.org/10.1007/s12161-022-02268-5.

Modelling biphasic hormetic dose responses to predict sub-NOAEL effects using plant biology as an example - (Peer Reviewed Journal)
Belz, R.G., Duke, S.0. 2022. Modelling biphasic hormetic dose responses to predict sub-NOAEL effects using plant biology as an example. Current Opinion in Toxicology. https://doi.org/10.1016/j.cotox.2022.01.003.

The potential influence of hormesis on evolution of resistance to herbicides - (Peer Reviewed Journal)
Belz, R.G., Carbonari, C.A., Duke, S.O. 2022. The potential influence of hormesis on evolution of resistance to herbicides. Current Opinion in Environmental Science & Health. https://doi.org/10.1016/j.coesh.2022.100360.

A multitarget approach to evaluate the efficacy of Aquilaria sinensis flower extract against metabolic syndrome - (Peer Reviewed Journal)
Chae, H., Dale, O., Maqbool, M., Zhao, J., Avula, B., Khan, I.A., Khan, S.I. 2022. A multitarget approach to evaluate the efficacy of Aquilaria sinensis flower extract against metabolic syndrome. Molecules. https://doi.org/10.3390/molecules27030629.

Undescribed C-Glycosylflavones from corn silk and potential anti-inflammatory activity evaluation of isolates - (Peer Reviewed Journal)
Sarfare, S., Khan, S.I., Zulfiqar, F., Radhakrishnan, S., Ali, Z., Khan, I.A. 2022. Undescribed C-Glycosylflavones from corn silk and potential anti-inflammatory activity evaluation of isolates. Planta Medica. https://doi.org/10.1055/a-1728-1347.

Structure simplification of natural products as a lead generation approach in crop protection compound discovery - (Peer Reviewed Journal)
Sparks, T.C., Duke, S.O. 2021. Structure simplification of natural products as a lead generation approach in crop protection compound discovery. Journal of Agricultural and Food Chemistry. 69(30):8324-8346. https://doi.org/10.1021/acs.jafc.1c02616.