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ARS Home » Southeast Area » Athens, Georgia » U.S. National Poultry Research Center » Endemic Poultry Viral Diseases Research » Research » Research Project #441124
Research Project: Elucidation of Molecular Determinants of Avian Herpesviruses Virulence and Evolution to Inform the Development of Safe and Effective Vaccines

Location: Endemic Poultry Viral Diseases Research

Publications (Clicking on the reprint icon Reprint Icon will take you to the publication reprint.)

Non-targeted RNA sequencing: towards the development of universal clinical diagnosis methods for human and veterinary infectious diseases Reprint Icon - (Peer Reviewed Journal)
Afonso, C., Spatz, S.J. 2024. Non-targeted RNA sequencing: towards the development of universal clinical diagnosis methods for human and veterinary infectious diseases. Veterinary Sciences. https://doi.org/10.3390/vetsci11060239.

Comparative analysis of multiple consensus genomes of the same strain of Marek’s disease virus reveals intrastrain variation - (Peer Reviewed Journal)

Efficacy of recombinant Marek’s disease vaccine 301B/1 expressing membrane-anchored chicken interleukin-15 Reprint Icon - (Peer Reviewed Journal)
Kim, T.N., Hearn, C.J., Heidari, M. 2024. Efficacy of recombinant Marek’s disease vaccine 301B/1 expressing membrane-anchored chicken interleukin-15. Avian Diseases. 68(2):117-128. https://doi.org/10.1637/aviandiseases-D-23-00068.

Construction of recombinant Marek’s disease virus vaccine expressing sigma C proteins of avian reoviruses - (Abstract Only)

Phenotypic characterization of recombinant Marek’s disease virus in live birds validates polymorphisms associated with virulence Reprint Icon - (Peer Reviewed Journal)
Kim, T.N., Hearn, C.J., Mays, J.K., Velez-Irizarry, D., Reddy, S.M., Spatz, S.J., Cheng, H.H., Dunn, J.R. 2023. Phenotypic characterization of recombinant Marek’s disease virus in live birds validates polymorphisms associated with virulence. Viruses. 15(11):2263. https://doi.org/10.3390/v15112263.

Molecular characterization and phylogenetic analysis of Marek's disease virus in chickens from Ogun State, Nigeria Reprint Icon - (Peer Reviewed Journal)
Oluwayinka, E.B., Otesile, E.B., Oni, O.O., Ajayi, O.L., Dunn, J.R. 2023. Molecular characterization and phylogenetic analysis of Marek's disease virus in chickens from Ogun State, Nigeria. Avian Pathology. 52(6):401-411. https://doi.org/10.1080/03079457.2023.2243838.

Proteogenomic and expression profiling of Marek’s disease virus during fully productive replication in the host - (Abstract Only)

Virulence determination of Marek's disease virus that changed multiple nucleotides in virulence-related open reading frames. - (Proceedings)

The alphaherpesvirus conserved pUS10 is important for natural infection and its expression is regulated by the conserved Herpesviridae protein kinase (CHPK) Reprint Icon - (Peer Reviewed Journal)
Ponnuraj, N., Akbar, H., Arrington, J.V., Spatz, S.J., Nagarajan, B., Desai, U.R., Jarosinski, K.W. 2023. The alphaherpesvirus conserved pUS10 is important for natural infection and its expression is regulated by the conserved Herpesviridae protein kinase (CHPK). PLoS Pathogens. 19(2):e1010959. https://doi.org/10.1371/journal.ppat.1010959.

Targeted ablation of exon 2 of the Avian Leukosis Virus-A (ALV-A)receptor gene in a chicken fibroblast cell line by CRISPR abrogates ALV-A infection Reprint Icon - (Peer Reviewed Journal)
Conrad, S.J., Mays, J.K., Hearn, C.J., Dunn, J.R. 2023. Targeted ablation of exon 2 of the Avian Leukosis Virus-A (ALV-A)receptor gene in a chicken fibroblast cell line by CRISPR abrogates ALV-A infection. Avian Diseases. 67(1):102-107. https://doi.org/10.1637/aviandiseases-D-22-00072.

Fast forwarding evolution – accelerated adaptation in a proofreading deficient hypermutator herpesvirus Reprint Icon - (Peer Reviewed Journal)
Xing, N., Hofler, T., Hearn, C.J., Nascimento, M., Camps Paradell, G., Mcmahon, D.P., Kunec, D., Cheng, H.H., Trimpert, J., Osterrieder, N. 2022. Fast forwarding evolution – accelerated adaptation in a proofreading deficient hypermutator herpesvirus. Virus Evolution. 8(2):veac099. https://doi.org/10.1093/ve/veac099.

Coinfection in the host can result in functional complementation between live vaccines and virulent virus Reprint Icon - (Peer Reviewed Journal)
Xu, H., Kriter, A.L., Ponnuraj, N., Tien, Y., Kim, T.N., Jarosinski, K.W. 2022. Coinfection in the host can result in functional complementation between live vaccines and virulent virus. Virulence. 13(1):980-989. https://doi.org/10.1080/21505594.2022.2082645.

The conserved Herpesviridae protein kinase (CHPK) of Gallid alphaherpesvirus 3 (GaHV3) is required for horizontal spread and natural infection in chickens Reprint Icon - (Peer Reviewed Journal)
Krieter, A., Xu, H., Akbar, H., Kim, T.N., Jarosiniski, K.W. 2022. The conserved Herpesviridae protein kinase (CHPK) of Gallid alphaherpesvirus 3 (GaHV3) is required for horizontal spread and natural infection in chickens. Viruses. 14(3):586. https://doi.org/10.3390/v14030586.