Location: Zoonotic and Emerging Disease Research
Project Number: 3022-32000-021-003-S
Project Type: Non-Assistance Cooperative Agreement
Start Date: Sep 1, 2022
End Date: Aug 31, 2025
Objective:
The overall objective of this agreement is to increase the knowledge on the epidemiology, ecology, and pathogenesis of Crimean-Congo Hemorrhagic Fever virus.
Approach:
1- Identifying alternative tick vectors and evaluating their vector competence compared to Hyalomma ticks.
2- Identifying viral elements mediating pathogenesis and persistence in the reservoir.
NGS sequencing will be used to obtain comprehensive genomic data from virus isolates. RNA seq and proteomics will be performed on vertebrate and tick cells infected with CCHFV, in order to compare the expression profiles and identify potential pathogenesis and maintenance pathways.
