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Title: BEAUVERICIN NOT AN ACUTE TOXIN TO DUCKLING BIOASSAY

Author
item Vesonder, Ronald
item WU, WEIDONG - U OF WI, MADISON, WI
item McAlpin, Cesaria

Submitted to: American Phytopathological Society Abstracts
Publication Type: Abstract Only
Publication Acceptance Date: 8/12/1999
Publication Date: N/A
Citation: N/A

Interpretive Summary:

Technical Abstract: Acute toxic effect of beauvericin (BEA) was investigated in newly hatched white Pekin ducklings by oral doses. The purified BEA administered by gastric intubation produced no 7-day median lethal dose response at doses up to 100 mg/kg body weight compared to T-2 toxin and moniliformin (MON) 7-day median lethal dose of 4.5 and 4.1 mg/kg body weight respectively. Two isolates of Fusarium subglutinans were fermented on rice at 25C for 21 days. Mycotoxin analysis of the fermented rice for BEA, (MON) by analytical HPLC revealed only the presence of BEA. Each Fusarium-fermented rice containing BEA, when dried and mixed into a poultry diet (10% by weight), caused no acute mortality in baby Pekin ducklings. Ducklings fed Fusarium infected rice containing MON caused acute mortality (less than 48 hr) and correlated significantly with the amount of MON in the fermented rice. BEA role in poultry mycotoxicoses has not been investigated, and these results demonstrate BEA is not an acute toxin to duckling bioassay and further studies are needed to determine its role in longer feeding studies.