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ARS Home » Plains Area » Grand Forks, North Dakota » Grand Forks Human Nutrition Research Center » Dietary Prevention of Obesity-related Disease Research » Research » Publications at this Location » Publication #105764
Title: ISOLATED VENTRICULAR MYOCYTES FROM COPPER-DEFICIENT RAT HEARTS EXHIBIT ENHANCED CARDIAC CONTRACTILE FUNCTION

Author
item WOLD, LOREN - UNIV OF NORTH DAKOTA
item Saari, Jack
item REN, JUN - UNIV OF NORTH DAKOTA

Submitted to: Meeting Abstract
Publication Type: Abstract Only
Publication Acceptance Date: 9/17/1999
Publication Date: N/A
Citation: Wold, L.E., Saari, J.T., Ren, J. 1999. Isolated ventricular myocytes from copper-deficient rat hearts exhibit enhanced cardiac contractile function [abstract]. 2nd Biennial Joint EPSCoR Conference (North and South Dakota)Abstracts. p.29.

Interpretive Summary:

Technical Abstract: Copper-deficiency (CD) leads to cardiac hypertrophy, fibrosis, and contractile dysfunction. This study was conducted to determine if the impaired cardiac function is due to abnormalities at the single cell level. Rats were fed with either copper-adequate or copper-deficient diets for 5 weeks. The CD rats displayed cardiac, hepatic and renal hypertrophy. Myocytes from CD hearts exhibited significantly enhanced myocyte shortenin with reduced shortening duration. These data suggest that cardiac contractile dysfunction seen in CD hearts may not be due to depressed contractile function at the single cell level, but rather due to other mechanisms, such as fibrosis.