Author
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King, Jerry |
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Submitted to: Journal of Chromatography
Publication Type: Book / Chapter Publication Acceptance Date: 10/24/2001 Publication Date: N/A Citation: N/A Interpretive Summary: Technical Abstract: Supercritical fluid chromatography (SFC) was first investigated in the late 1960's as a potential analytical technique but gained little acceptance due to the complex instrumentation involved in performing separations. Beginning in the middle 1970's, these experimental difficulties were overcome, and commercial SFC instrumentation became available by the early 1980's. Although SFC is often viewed by many as an analytical technique, this article illustrates its universal applicability for sample preparation, preparative/production scale operation, and as a valuable tool for determining physicochemical properties relevant to the supercritical fluid state. SFC experiments and technique can be designed for investigated solubility and adsorption phenomena that are required when performing SFC's analogue, supercritical fluid extraction (SFE). Off-line SFE has emerged as the most extensively used form of analytical SFE; however, the off-line mode can be a valuable optional technique for specific types of problems where a small sample is involved. Examples are provided of specific separation and analysis problems that can be solved rapidly by using SFC, the advantageous coupling of SFC with SFE, and scaling up SFC for the production of high value nutraceutical grade chemicals for human consumption. |
