Skip to main content
ARS Home » Research » Publications at this Location » Publication #109379
Title: ENCAPSULATION OF INSULIN IN STARCH-OIL COMPOSITES

Author
item Erhan, Selim
item WANG, DAVID - UNIV IL MEDICAL SCHOOL
item WANG, LIJUAN - UNIV IL MEDICAL SCHOOL

Submitted to: American Oil Chemists' Society Meeting
Publication Type: Abstract Only
Publication Acceptance Date: 4/28/2000
Publication Date: N/A
Citation: N/A

Interpretive Summary:

Technical Abstract: Fantesk**TM is a multipurpose carrying agent. It is a composite, prepared by co-jet cooking oil, water, and starch. This cooking produces a very stable emulsion, a lubricous fluid gel, containing up to 50% oil. It can be drum dried to a film and reduced to a dry, non-oily powder. This powder, which is stable, can be resuspended in water to produce a stable gel resembling the original gel from the jet-cooker. This dispersion acts as an emulsifier for lipid materials. Lipophilic compounds that are sensitive to oxidation and heat can be blended at room temperature into a Fantesk**TM emulsion without effecting the emulsion stability. Several formulations were prepared to encapsulate insulin for oral delivery. Insulin was successfully encapsulated in a double Fantesk**TM emulsion. These formulations were freeze dried. The resulting white powder was easily reconstituted into water at room temperature. Muscle injections of the original emulsion and emulsions prepared by reconstituting the powder showed that the insulin was active in these formulations even after 18 mos when stored at 0 deg C.