Author
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Holt, Peter |
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Submitted to: Midwest Poultry Federation Proceedings
Publication Type: Abstract Only Publication Acceptance Date: 3/3/2000 Publication Date: 3/27/2003 Citation: Holt, P.S. 2003. A review of current salmonella vaccines available. Midwest Poultry Federation Proceedings. Interpretive Summary: Technical Abstract: Because of increasing demands by government and the consumer for reduced levels of Salmonella contamination in poultry and poultry products, industry has sought methods to reduce Salmonella infections in poultry flocks. Vaccination is one intervention scheme receiving increased reassessment as a means to combat the Salmonella problem. There are two main vaccine types available to immunize poultry against Salmonella: live and inactivated. Both methods have their pluses and minuses. Live vaccines stimulate both systemic and intestinal antibody responses as well as activating cell mediated immunity, immunity shown to be important in mammalian studies for protecting individuals against the organism. However, being a potential human pathogen and therefore possibly reverting back to a virulent organism, live vaccines are still viewed with some trepidation by producers. Inactivated vaccines containing killed Salmonella bacteria in an oil emulsion formulation are much more accepted by industry. Because the vaccine only contains killed organism, there is no chance for vaccine-produced infections. However, the vaccine only produces strong serum antibody response and a little intestinal immunity resulting from bile entry into the intestine. Both vaccine types provide good protection against Salmonella infections in poultry and it is up to the producer to decide which vaccine type works best for his situation. |
