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ARS Home » Research » Publications at this Location » Publication #110895
Title: CHARACTERIZATION OF THE IRS/US/TRS JUNCTION REGION IN DIFFERENT MDV ISOLATES

Author
item Lupiani, Blanca
item Silva, Robert
item Reddy, Sanjay
item Lee, Lucy
item Kutish, Gerald
item Rock, Daniel

Submitted to: World Poultry Congress Proceedings
Publication Type: Abstract Only
Publication Acceptance Date: 8/20/2000
Publication Date: N/A
Citation: N/A

Interpretive Summary:

Technical Abstract: Serotype 1 MDV is classified according to pathotypes. The typical standard pathotype (vMDV) includes the strains GA and JM; the very virulent pathotype (vvMDV) includes Md5 and Md11 and the very virulent plus pathotype (vvMDV+) includes recently isolated hot strains such as 648A and 584A. The complete nucleotide sequence of the GA and Md5 strains is now available. Sequence analysis of the IRS/US/TRS regions of GA and MD5 indicated significant differences of the junction regions. The IRS and TRS regions are longer in Md5 than in GA resulting in a partial duplication of SORF2 at both ends of the US region. The new protein generated at the US/TRS junction , SORF2 like, is 149 aa long and shares the 119 amino end acids with SORF2. The IRS/US/TRS junctions of different MDV pathotypes will be characterized and compared to those of Md5 and GA.