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ARS Home » Plains Area » Houston, Texas » Children's Nutrition Research Center » Research » Publications at this Location » Publication #112847
Title: BONE TURNOVER ASSESSMENT IN INFANTS

Author
item LAPILLONNE, ALEXANDRE - BAYLOR COLLEGE OF MED
item PICAUD, JEAN-CHARLES - HOPITAL EDOUARD HERRIOT
item GLORIEUX, FRANCIS - SHRINERS HOSP, MONTREAL
item SALLE, BERNARD - HOPITAL EDOUARD HERRIOT

Submitted to: Acta Paediatrica
Publication Type: Review Article
Publication Acceptance Date: 4/25/2000
Publication Date: N/A
Citation: N/A

Interpretive Summary:

Technical Abstract: The recent availability of biochemical markers is a major methodological advance in assessing bone turnover. Bone disease disrupts the usual patterns of these bone markers. Diseases that lead to osteopenia reduce the ratio of bone formation markers relative to bone resorption markers. These markers provide a dynamic assessment of the skeleton that potentially can be used in combination with measurements of bone mineral content. The use of these markers in pediatrics is likely to continue to increase because these measurements are noninvasive, relatively inexpensive, generally available, capable of measuring changes in bone turnover over short intervals, and useful in long-term studies. Their increased usages, in turn, has the potential to result in better selection of patients for therapy, tailoring of specific therapies to different types of patients, and better monitoring of the effectiveness of individual therapies.