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Title: MEQ, AN MDV-SPECIFIC BZIP TRANSACTIVATOR WITH TRANSFORMING PROPERTIES

Author
item KUNG, HSING-JIEN - CASE WESTERN UNIV CLEV OH
item XIA, LIANG - CASE WESTERN UNIV CLEV OH
item BRUNOVSKIS, PETER - CASE WESTERN UNIV CLEV OH
item LI, DESHAN - CASE WESTERN UNIV CLEV OH
item LIU, JUINN-LIN - CASE WESTERN UNIV CLEV OH
item Lee, Lucy

Submitted to: Current Topics in Microbiology and Immunology
Publication Type: Book / Chapter
Publication Acceptance Date: 10/8/2000
Publication Date: 12/31/2000
Citation: KUNG, H., XIA, L., BRUNOVSKIS, P., LI, D., LIU, J., LEE, L.F. MEQ, AN MDV-SPECIFIC BZIP TRANSACTIVATOR WITH TRANSFORMING PROPERTIES. HIRAI, K. EDITOR. SPRINGER-VERLAG, NEW YORK. CURRENT TOPICS IN MICROBIOLOGY AND IMMUNOLOGY. 2000. V. 255. P. 245-260.

Interpretive Summary:

Technical Abstract: In this review we described the properties and functions of Meq. It is clear that Meq is a versatile protein and likely to participate in both transforming and replication functions of MDV. Yet, despite all these studies, the crucial evidence that Meq is involved in oncogenesis or latency is still lacking, largely due to the difficulty in conducting genetic analyses of MDV. The cell-associated nature of MDV makes the cloning of genetic mutants more difficult. The elegant technique developed by Morgan and Parcells (Parcells et al. 1999) has overcome some of the difficulties and provides means to alter individual genes of MDV. The recent completion of the sequence determination of MDV genome should also greatly facilitate the genetic analysis (Lee et al. 2000). In addition, the development of high throughput analyses such as DNA chip and microarray will allow rapid identification of Meq targets and the study of the genes involved in replication and latency. Thus, while Meq has been identified almost a decade ago this is an exciting Juncture when we can put all the information together to understand its in vivo functions.