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Title: SEQUENCE ANALYSIS OF MAREK'S DISEASE VIRUS GENE ENCODING THE MAJOR CAPSID PROTEIN

Author
item Reddy, Sanjay
item SUI, D - AVIAN DISEASE ONCOL LAB
item WU, PING - AVIAN DISEASE ONCOL LAB
item QIN, AIJIAN - AVIAN DISEASE ONCOL LAB
item Lee, Lucy

Submitted to: World Poultry Congress Proceedings
Publication Type: Proceedings
Publication Acceptance Date: 8/20/2000
Publication Date: N/A
Citation: N/A

Interpretive Summary:

Technical Abstract: Marek's disease virus (MDV), a member of the alpha-herpesvirus family, is the etiological agent of Marek's disease. DNA sequence analysis revealed a gene encoding the major capsid protein (MCP) in the BamHI C and F fragments. Identification was based on extensive amino acid homology with MCP of other herpesviruses. MCP's play an important role in viral capsid structure and assembly. We describe here a 4053 base pair fragment of MDV encoding a putative MCP of 1351 amino acids with a relative molecular weight of 150 kDa. MDV MCP showed extensive homology to six distantly related herpesviruses. Data on the characterization of MCP will be discussed.