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ARS Home » Midwest Area » Ames, Iowa » National Animal Disease Center » Food Safety and Enteric Pathogens Research » Research » Publications at this Location » Publication #123890
Title: SECRETION OF A PUTATIVE CYTOTOXIN IN MULTIPLE ANTIBIOTIC RESISTANT SALMONELLA ENTERICA SEROTYPE TYPHIMURIUM PHAGETYPE DT104

Author
item CARLSON, STEVEN
item MEYERHOLZ, DAVID - IOWA STATE UNIVERSITY
item STABEL, THOMAS
item JONES, BRADLEY - UNIVERSITY OF IOWA

Submitted to: Microbial Pathogenesis
Publication Type: Peer Reviewed Journal
Publication Acceptance Date: 6/24/2001
Publication Date: N/A
Citation: N/A

Interpretive Summary: Salmonella enterica serotype Typhimurium phagetype DT104 (DT104) is a multiple antibiotic resistant pathogen. DT104 infections have been reported in a multitude of hosts including humans, companion animals, livestock, and wildlife. Recently, several isolates of DT104 were recovered from veal calves exhibiting abomasitis. Abomasitis is an inflammation of the "true" stomach of cattle and it is not usually associated with a Salmonella infection. Using an intestinal infection model we found that multiple antibiotic resistant DT104 can elaborate a toxin that damages cells. This information is useful to scientists; veterinarians, especially those working in a diagnostic lab; and farmers.

Technical Abstract: Salmonella enterica serotype Typhimurium phagetype DT104 (DT104) is a multiple antibiotic resistant pathogen. DT104 infections have been reported in a multitude of hosts including humans, companion animals, livestock and wildlife. Recently, several isolates of DT104 were recovered from veal calves exhibiting abomasitis, a finding that is inconsistent with classic salmonellosis. One of these isolates was used in murine ligated loop experiments where it was observed that multiresistant DT104 can elaborate a putative cytotoxin. Thus it appears that DT104 has the ability to evade pharmacologic interventions, via antibiotic resistance, and also to elaborate a toxin that can damage cells.