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ARS Home » Plains Area » Grand Forks, North Dakota » Grand Forks Human Nutrition Research Center » Healthy Body Weight Research » Research » Publications at this Location » Publication #124389
Title: LOW COPPER INTAKE REDUCES SERUM IGF-1 AND BONE STRENGTH

Author
item Hill, Kathleen
item Lukaski, Henry
item Roughead, Zamzam

Submitted to: Meeting Abstract
Publication Type: Abstract Only
Publication Acceptance Date: 7/11/2001
Publication Date: 7/25/2001
Citation: Hill, K.M., Lukaski, H.C., Roughead, Z.K. 2001. Low copper intake reduces serum IGF-1 and bone strength [abstract]. Proceedings of the 9th Annual Experimental Program to Stimulate Competitive Research (EPSCOR). Abstract #53. p.15.

Interpretive Summary:

Technical Abstract: In a study of graded intakes of copper and zinc in growing rats, dietary copper was the main determinant of serum insulin-like growth factor-1 (IGF- 1), femur density, and strength. Compared to the high copper groups, the rats fed the low copper diet had significantly lower serum IGF-1 (27%), femur density (3%) and strength (12%). Low serum IGF-1 may, in part, explain the adverse effects of low copper intake on bone status.