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ARS Home » Research » Publications at this Location » Publication #125056
Title: TRACE TOXICANT ANALYSIS IN TISSUE SAMPLES USING CRITICAL FLUID MEDIA

Author
item King, Jerry
item Curren, Meredith

Submitted to: Pittsburgh Conference
Publication Type: Abstract Only
Publication Acceptance Date: 11/21/2001
Publication Date: N/A
Citation: N/A

Interpretive Summary:

Technical Abstract: Extraction of trace toxicants using environmentally-benign supercritical and pressurized fluids offers many benefits, including elimination or reduction of hazardous extraction solvents and their attendant disposal costs. In addition, methods based on critical fluids frequently result in faster extractions with integrated cleanup of the extract prior to analysis. In this presentation, pressurized water modified with structure breaking additives, such as ethanol, have been used for the extraction and in-situ cleanup of fortified atrazine and avoparcin-containing sample matrices. Sorbent addition, MSPD (matrix solid phase dispersion) to the sample, aids in the comminution of the matrix as well as providing selective retention of coextractives that interfere in the final analysis. Both solid phase microfiber extraction (SPME) and solid phase extraction (SPE) are utilized after the pressurized extraction to isolate the target analyte from the dilute aqueous extract. Utilizing the above techniques, complete recoveries can be achieved from kidney tissue for atrazine and avoparcin. General correlations for predicting the solubility of a solute (analyte) in subcritical water and modified subcritical water will also be presented, as well as guidelines for the selection of the MSPD sorbent, SPME fiber, and additive addition to the aqueous medium.