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Title: MAREK'S DISEASE VIRUS ENCODES A NOVEL IL8-LIKE CHEMOKINE

Author
item CUI, XIAOPING - MICHIGAN STATE UNIVERSITY
item Lee, Lucy
item REED, WILLIE - MICHIGAN STATE UNIVERSITY
item KUNG, HSING - UC DAVIS CANCER CENTER
item Reddy, Sanjay

Submitted to: North Central Avian Disease Conference
Publication Type: Abstract Only
Publication Acceptance Date: 10/1/2001
Publication Date: 7/14/2002
Citation: CUI, X., LEE, L.F., REED, W., KUNG, H.J., REDDY, S.M. MAREK'S DISEASE VIRUS ENCODES A NOVEL IL8-LIKE CHEMOKINE. NORTH CENTRAL AVIAN DISEASE CONFERENCE. 2002.

Interpretive Summary:

Technical Abstract: Marek's disease virus (MDV) is an alpha herpesvirus that induces an economically important cancer-like disease in chickens. Recently, a new IL8-like gene encoded by MDV (vIL8) has been identified, but its function in MDV is unknown. It has been shown that lymphoid cells are the primary target cells for infection and transformation by MDV. VIL8 may play an important role in recruiting proper target cells, as the recruitment of such lymphoid cells is crucial in the establishment of Marek's disease. Using rabbit anti-vIL8 peptide serum, we localized vIL8 expression in the cytoplasm of MDV infected cells. Recombinant Baculovirus was used to over express vIL8 in insect cells. The in vitro role of vIL8 will be further studied using the expressed protein.