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ARS Home » Research » Publications at this Location » Publication #126318
Title: SINGLE NUCLEOTIDE POLYMORPHISMS (SNPS)-A NEW GENERATION OF DNA MARKER

Author
item Cregan, Perry
item ZHU, YOULIN - CHINA
item SONG, QIJIAN - CHINA

Submitted to: American Society of Agronomy Meetings
Publication Type: Abstract Only
Publication Acceptance Date: 10/5/2001
Publication Date: N/A
Citation: N/A

Interpretive Summary:

Technical Abstract: Single DNA base changes between homologous DNA fragments plus small insertions and deletions, collectively referred to as single nucleotide polymorphisms (SNPs), are the most abundant source of DNA polymorphisms in most organisms. The driving force in SNP discovery and detection is the wide ranging applications for human SNPs which range from the study of the genetic control of disease to the prediction of an individual's response to medication. A number of biotech companies including Genset, Paris, France; Celera Genomics Corporation, Rockville, MD, USA; and Incyte Pharmaceuticals, Palo Alto, CA, USA, as well as the U.S. National Institutes of Health have announced plans to create libraries of tens of thousands of SNPs. In April 1999, the SNP Consortium (http://snp.cshl.org/) composed of 10 pharmaceutical companies and Great Britain's Wellcome Trust initiated research to discover 300,000 SNPs and release all sequence information to the public free of charge. One result of these efforts has been accelerated development of a wide range of technologies for high-throughput low-cost SNP detection. The development of high-throughput low-cost detection combined with the likely abundance of SNPs in plant genomes strongly suggest that SNPs will become the consensus marker system in plants for relating QTLs to candidate genes, gene isolation, and marker assisted plant improvement.