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Title: MOUSE CYTOKINE PROFILES IN MICE ASSOCIATED TO BRUCELLA ABORTUS RB51 VACCINATION OR TO B. ABORTUS 2308 INFECTION

Author
item PASQUALI, PAOLO - ROME ITALY
item ADONE, ROSANNA - ROME ITALY
item Gasbarre, Louis
item PISTOIA, CLAUDIA - ROME ITALY
item CUCHINI, FRANCO - ROME ITALY

Submitted to: Infection and Immunity
Publication Type: Peer Reviewed Journal
Publication Acceptance Date: 7/25/2001
Publication Date: 10/1/2001
Citation: PASQUALI, P., ADONE, R., GASBARRE, L.C., PISTOIA, C., CUCHINI, F. MOUSE CYTOKINE PROFILES IN MICE ASSOCIATED TO BRUCELLA ABORTUS RB51 VACCINATION OR TO B. ABORTUS 2308 INFECTION. INFECTION AND IMMUNITY. vol. 69, pp. 6541-6544, 2001.

Interpretive Summary: This study indicated that mice injected with the RB51 vaccine strain of the bacteria Brucella abortus RB51 were protected from a challenge infection with a lethal strain of the bacteria. The reason that the mice were resist and a challenge with the lethal bacteria was that they had an enhanced level of the important cytokine Interferon-gamma, and that this cytokine is important in immunity to the bacteria.

Technical Abstract: This study indicated that mice immunized with Brucella abortus RB51 bacteria and subsequently challenged with B.abortus 2308 were protected from reinfection. After vaccination both Th1 and Th2 cytokine patterns were observed. Of those, the early production of IFN-g seems to have the prominent role in inducing an immunologically-based protection.