THE ACUTE PHASE RESPONSE IN E. COLI CHALLENGED PIGS TREATED WITH SYSTEMIC ANTIBIOTICS

Authors: HAMBACH, ANDREA - UNIVERSITY OF MO; FANGMAN, THOMAS - UNIVERSITY OF MO; Carroll, Jeffery - Jeff Carroll

Submitted to: American Association of Swine Veterinarians Annual Meeting
Publication Type: Proceedings
Publication Acceptance Date: 3/2/2002
Publication Date: N/A
Citation: N/A

Interpretive Summary:

Technical Abstract: Changes in serum C-reactive protein (CRP), haptoglobin (HG) and cortisol (CS), and rectal temperature (RT) were evaluated in response to an acute enterotoxemia elicited by antibiotic injection. Twenty-four, 24-day old, pigs were individually housed and provided feed and water ad libitum. Twelve pigs were non-surgically cannulated for blood collection and RT was monitored on the remaining 12 pigs. All pigs received a 10-mL oral dose of 2.4 X 10**8 colony-forming units of E. coli K88. Five hours later, 6 pigs in each group were injected with .5 mL of saline (Group A) or 25 mg of Ceftiofur HCl (Group B). Blood collection and RT monitoring occurred hourly from -1 hr to 5 hr post-E. coli (PRE). Between 5 and 8 hr, blood collection and RT monitoring occurred every .5 hr with a final collection at 24 hr post-E. coli (POST). RT increased over time (P<.0001) in both groups during the PRE period. During the POST period, a time X treatment interaction (P<.02) was observed such that Group B pigs had higher RT compared to Group A pigs. A time x treatment interaction (P<.0001) was observed for CRP between groups. CRP in Group B rose .5 hr POST, whereas in Group A there was no additional rise in CRP. No differences were observed in HG during the PRE period. During the POST period, there was an increase (P<.0001) in HG for both groups. CS increased (P<.0001) over time for both groups during the PRE period. During the POST period, a time X treatment interaction (P=.05) was observed such that CS was higher in Group B pigs.