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Title: ANTIMICROBIAL SUSCEPTIBILITY PATTERNS FOR SALMONELLA ISOLATES OF ANIMAL ORIGIN, NARMS 2001

Author
item HEADRICK, MARCIA - FDA - CVM
item Cray, Paula
item TOLLEFSON, LINDA - FDA - CVM
item DARGATZ, DAVID - USDA-APHIS
item WINELAND, NORA - USDA-APHIS
item ANANDARAMAN, NEENA - USDA-FSIS
item SALAMONE, BEN - USDA-FSIS
item ROSE, BONNIE - USDA-FSIS

Submitted to: American Society for Microbiology
Publication Type: Abstract Only
Publication Acceptance Date: 3/18/2003
Publication Date: 5/18/2003
Citation: Headrick, M., Cray, P.J., Tollefson, L., Dargatz, D.A., Wineland, N.E., Anandaraman, N., Salamone, B., Rose, B. 2003. Antimicrobial susceptibility patterns for salmonella isolates of animal origin, narms 2001. American Society for Microbiology. aBSTRACT. y-018. p. 94.

Interpretive Summary:

Technical Abstract: Background: The National Antimicrobial Susceptibility Monitoring System-Enteric Bacteria (NARMS-EB) was established to provide descriptive data on the extent and temporal trends of antimicrobial resistance in zoonotic enteric pathogens from human and animal populations. Salmonella was chosen as the sentinel organism. Methods: As part of the 2001 study, 5,739 Salmonella isolates of animal origin were tested against 18 antimicrobials using a SensititreTM custom designed microtiter plate. Minimal inhibitory concentrations (MICs) were determined for all antimicrobials. Animal sources of isolates included cattle, swine, chickens, turkeys, exotics, horses, dogs, and cats. These isolates were from both diagnostic and non-diagnostic submissions. Results: Overall, all isolates were susceptible to Amikacin and Ciprofloxacin. The following percent sensitivity was observed for all other antimicrobials - Amoxicillin/clavulanic acid (82.0%), Ampicillin (72.3%), Apramycin (98.4%), Cefoxitin (88.1%), Ceftiofur (88.4%), Ceftriaxone (94.1%), Cephalothin (84.8%), Chloramphenicol (82.7%), Gentamicin (88.7%), Imipenem (99.9%), Kanamycin (83.5%), Nalidixic Acid (98.0%), Streptomycin (61.5%), Sulfamethoxazole (64.5%), and Trimethoprim/sulfa (95.7%). Breakpoints for Tetracycline did not enable accurate determination of susceptibility to that antimicrobial. Overall resistance to Tetracycline was 44.1%. For all antimicrobials, isolates collected from raw product were more susceptible than diagnostic isolates. Over one hundred serotypes were identified, and the 5 most common serotypes were S. Typhimurium (including var. copenhagen, n=934), S. Heidelberg (n=630), S. Kentucky (n=538), S. Newport (n=455), and S. Cholerasuis var. kunzendorf (n=273). Conclusion: These data provide information that can be used to evaluate trends in antimicrobial resistance over time, within species class and source of isolates, when compared to previous years.