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Title: RESPONSE OF WHITE LEGHORN CHICKENS OF VARIOUS B HAPLOTYPE TO INFECTION WITH SUBGROUP J AVIAN LEUKOSIS VIRUS

Author
item Mays, Jody
item BACON, LARRY - USDA-ARS-MWA-ADOL
item PANDIRI, ARUN - MICHIGAN STATE UNIVERSITY
item Fadly, Aly

Submitted to: American Veterinary Medical Association Abstract
Publication Type: Abstract Only
Publication Acceptance Date: 7/19/2003
Publication Date: 12/31/2003
Citation: MAYS, J., BACON, L., PANDIRI, A., FADLY, A. RESPONSE OF WHITE LEGHORN CHICKENS OF VARIOUS B HAPLOTYPE TO INFECTION WITH SUBGROUP J AVIAN LEUKOSIS VIRUS. XIII CONGRESS OF WORLD VETERINARY POULTRY ASSOCIATION. 2003. ABSTRACT P. 99.

Interpretive Summary:

Technical Abstract: Chickens from seven 15.B congenic lines (genetically identical except for the MHC B haplotype) and Line 0 and Line 0.B semicongenic lines, were infected with strain ADOL HC-1 of subgroup J Avian Leukosis virus (ALV-J) at hatch. At 5, 8, and 16 weeks of age, chickens were tested for ALV-J-induced viremia, antibody, and cloacal shedding; chickens were also monitored for development of ALV-J tumors. By 16 weeks of age, the incidence of viremia and shedding was comparable in all 15.B congenic lines (B*2, B*5, B*12, B*15, B*19, and B*21) regardless of B haplotype. However, the incidence of viremia in Line 0 and 0.B semicongenic lines (Line 0-21 and Line 0.P-13) was significantly lower than in the 15.B congenic lines, 15.P-13 and 15.N-21, which express the same B haplotype. Results suggest that line of chicken, but not B haplotype may influence ALV-J infection.