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ARS Home » Research » Publications at this Location » Publication #151726
Title: COORDINATED EXPRESSION OF TRACHEAL ANTIMICROBIAL PEPTIDE AND INFLAMMATORY-RESPONSE ELEMENTS IN THE LUNGS OF NEONATAL CALVES WITH ACUTE BACTERIAL PNEUMONIA

Author
item CAVERLY, J - IA STATE UNIV., AMES, IA
item DIAMOND, G - IA STATE UNIV., AMES, IA
item GALLUP, J - IA STATE UNIV., AMES, IA
item BROGDEN, KIM
item DIXON, R - IA STATE UNIV., AMES, IA
item ACKERMANN, MARK - IA STATE UNIV., AMES, IA

Submitted to: Infection and Immunity
Publication Type: Peer Reviewed Journal
Publication Acceptance Date: 1/20/2003
Publication Date: 5/20/2003
Citation: CAVERLY, J.M., DIAMOND, G., GALLUP, J.M., BROGDEN, K.A., DIXON, R.A., ACKERMANN, M.R. COORDINATED EXPRESSION OF TRACHEAL ANTIMICROBIAL PEPTIDE AND INFLAMMATORY-RESPONSE ELEMENTS IN THE LUNGS OF NEONATAL CALVES WITH ACUTE BACTERIAL PNEUMONIA. INFECTION AND IMMUNITY. 2003. INFECTION AND IMMUNITY. v.71(5). p. 2950-2955.

Interpretive Summary: Respiratory tract diseases are a leading cause of loss from disease in the cattle, sheep and goat industries. Losses are from mortality, reduced feed efficiency, slaughter condemnations, and treatment measures. In this study, lung tissue removed from neonatal calves with acute Mannheimia haemolytica pneumonia showed that rapid up-regulation of the basal mRNA expression of tracheal antimicrobial peptide (TAP), NF-kappa B, and intercellular adhesion molecule 1 occurred after infection; TAP and interleukin 8 expression were highly correlated. This work suggests that the coordinated expression of beta-defensin and inflammatory elements occurs during bacterial pneumonia. Our findings are an important step in determining the molecular pathogenesis of shipping fever of cattle.

Technical Abstract: Lung tissue removed from neonatal calves with acute Mannheimia haemolytica pneumonia showed that rapid up-regulation of the basal mRNA expression of tracheal antimicrobial peptide (TAP), NF-kappa B, and intercellular adhesion molecule 1 occurred after infection; TAP and interleukin 8 expression were highly correlated. This work suggests that the coordinated expression of beta-defensin and inflammatory elements occurs during bacterial pneumonia.