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Submitted to: US Food and Drug Administration-Public Master File - Potassium Permanganate
Publication Type: Other Publication Acceptance Date: 5/1/2003 Publication Date: 5/1/2003 Citation: STRAUS, D.L. FDA PROTOCOL - A RANGE-FINDING FIELD STUDY ON THE USE OF POTASSIUM PERMANGANATE TO CONTROL MORTALITY ASSOCIATED WITH ICHTHYOPHTHIRIASIS IN CHANNEL CATFISH. US FOOD AND DRUG ADMINISTRATION-PUBLIC MASTER FILE - POTASSIUM PERMANGANATE. 2003. v.1. pp. 27. Interpretive Summary: Technical Abstract: Ichthyophthirius multifiliis is a common external protozoan parasite that invades the skin and gills of freshwater fish. When channel catfish fingerlings are raised at high densities, this parasite can eradicate an entire fish population unless its reproductive cycle is interrupted. The life cycle of I. multifiliis has been well documented; the reproductive cycle can be stopped by killing the infective theront or the detached trophont with various anti-protozoal drugs. Potassium permanganate is being looked at to control mortality caused by this parasite in fingerling channel catfish in a pond environment. Fish of this size are typically raised during a time of year when the occurrence of a parasite outbreak is most likely. Readily oxidizable substances rapidly reduce the amount of KMnO4 present after treatments and this initial permanganate demand diminishes the effective concentration. Therefore, it is imperative to study the efficacy of potassium permanganate in pond water. This is the fourth revision of this protocol and the study is intended to provide the U.S. Food and Drug Administration/Center for Veterinary Medicine (FDA/CVM) with range-finding field efficacy data. |
