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ARS Home » Northeast Area » Boston, Massachusetts » Jean Mayer Human Nutrition Research Center On Aging » Research » Publications at this Location » Publication #152808
Title: ASSOCIATION OF ENERGY INTAKE WITH PROSTATE CANCER IN A LONG-TERM STUDY: BALTIMORE LONGITUDINAL STUDY OF AGING (UNITED STATES)

Author
item HSIEH, LILLIAN - JOHNS HOPKINS UNIVERSITY
item CARTER, H. BALLENTINE - JOHNS HOPKINS UNIVERSITY
item LANDIS, PATRICIA - JOHNS HOPKINS UNIVERSITY
item TUCKER, KATHERINE - HNRCA
item METTER, JEFFREY - NAT INST AGING
item NEWSCHAFFER, CRAIG - JOHNS HOPKINS UNIVERSITY
item PLATZ, ELIZABETH - JOHNS HOPKINS UNIVERSITY

Submitted to: Urology
Publication Type: Peer Reviewed Journal
Publication Acceptance Date: 9/6/2002
Publication Date: 2/1/2003
Citation: HSIEH, L.J., CARTER, H., LANDIS, P.K., TUCKER, K.L., METTER, J., NEWSCHAFFER, C.J., PLATZ, E.A. ASSOCIATION OF ENERGY INTAKE WITH PROSTATE CANCER IN A LONG-TERM STUDY: BALTIMORE LONGITUDINAL STUDY OF AGING (UNITED STATES). UROLOGY. 2003:61;297-301.

Interpretive Summary: Animal studies have shown that eating less total calories slows tumor growth. Human studies looking at calorie intake and risk of prostate cancer, however, have been inconsistent. The objective of this study was to examine the association of total calorie intake and the types of food eaten with prostate cancer risk. We examined the diets of 444 men, aged 45 to 92, who were currently participating in the Baltimore Longitudinal Study of Aging. 68 of these men had prostate cancer, either diagnosed before or during the study. We found that men with higher total calorie intakes were more likely to have prostate cancer. The amounts of protein, fat, and carbohydrates eaten did not affect risk of prostate cancer. These results suggest that higher total calorie intake increases the risk of prostate cancer among men.

Technical Abstract: To examine the association of total energy intake and macronutrient contributors to energy with prostate cancer risk among men in the Baltimore Longitudinal Study of Aging. In the Baltimore Longitudinal Study of Aging cohort, 444 men completed at least one food frequency questionnaire (FFQ). At their earliest FFQ completion, men were 45 to 92 years old. The total number of prostate cancer cases (n = 68) consisted of men who were diagnosed with cancer before their FFQ completion (n = 46) and those who were diagnosed after their FFQ completion (n = 22). Multiple logistic regression analysis was used to calculate the odds ratio of prostate cancer and its 95% confidence interval.Total energy intake was positively associated with prostate cancer. Compared with the lowest quintile of energy intake, the odds ratio for the highest quintile was 3.79 (95% confidence interval 1.52 to 9.48, P TREND = 0.002). Energy-adjusted intakes of protein, fat, and carbohydrates were not statistically significantly associated with prostate cancer risk. This analysis, in which we used current energy intake as a surrogate for past prediagnostic intake, suggests a higher risk of prostate cancer with increased energy intake.