Author
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BAIROS, LYNN - HNRCA |
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DAWSON-HUGHES, BESS - HNRCA |
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ROUBENOFF, RONENN - HNRCA |
Submitted to: International Journal of Body Composition Research
Publication Type: Peer Reviewed Journal Publication Acceptance Date: 10/1/2002 Publication Date: 1/1/2003 Citation: BAIROS, L.M., DAWSON-HUGHES, B., ROUBENOFF, R. COMPARISON OF WHOLE AND REGIONAL BODY COMPOSITION MEASURED BY HOLOGIC QDR-200 AND LUNAR DPX-L DUAL-ENERGY X-RAY ABSORPTIOMETRY (DXA). International Journal of Body Composition Research. 2003;1:1-6. Interpretive Summary: Dual energy x-ray absorptiometry (DXA) scanners have become the standard instruments for measuring whole and regional body composition. In multicenter clinical trials, both Lunar and Hologic instruments are often intermixed. However, little is known about the differences between these instruments and the potential errors that such practice may cause. Therefore, we assessed the degree of agreement between Hologic QDR-2000 (fan-beam) and Lunar DPX-L (pencil-beam) absorptiometers. Seventy nine healthy volunteers were recruited, 41 women and 38 men, and underwent two DXA scans on the same day to compare lean, fat, and bone mineral density in whole body, appendages, and trunk. There were significant differences between the scanners for women and men in whole body lean, fat, bone, and percent body fat; leg lean, fat, and bone; and arm lean and fat (all p=0.0001). Women also showed significant differences in estimates of trunk fat (p=0.006) and arm bone (p=0.0001). These differences increased with increasing body mass, but not with age. We conclude that Lunar and Hologic densitometers give different estimates of regional and whole body soft-tissue composition, which are biased by increasing mass. Multicenter trials that combime data from the two manufacturers should address systematic differences between these instruments. Technical Abstract: Dual energy x-ray absorptiometry (DXA) scanners have become the standard instruments for measuring whole and regional body composition. In multicenter clinical trials, both Lunar and Hologic instruments are often intermixed. However, little is known about the differences between these instruments and the potential errors that such practice may cause. Therefore, we assessed the degree of agreement between Hologic QDR-2000 (fan-beam) and Lunar DPX-L (pencil-beam) absorptiometers. Seventy nine healthy volunteers were recruited, 41 women and 38 men, and underwent two DXA scans on the same day to compare lean, fat, and bone mineral density in whole body, appendages, and trunk. There were significant differences between the scanners for women and men in whole body lean, fat, bone, and percent body fat; leg lean, fat, and bone; and arm lean and fat (all p=0.0001). Women also showed significant differences in estimates of trunk fat (p=0.006) and arm bone (p=0.0001). These differences increased with increasing body mass, but not with age. We conclude that Lunar and Hologic densitometers give different estimates of regional and whole body soft-tissue composition, which are biased by increasing mass. Multicenter trials that combime data from the two manufacturers should address systematic differences between these instruments. |