COMPARATIVE MAPPING OF A CHROMOSOMAL REGION ASSOCIATED WITH A CONFORMATIONAL TRAIT LOCUS IN DAIRY CATTLE

Authors: Connor, Erin; Sonstegard, Tad; Ashwell, Melissa; MATUKAMALLI, LAKSHMI - GEORGE MASON UNIVERSITY; Lake, Jill; Shade, Larry; Bennett, Gary; WILLIAMS, J - ROSLIN INSTITUTE

Submitted to: Germplasm Release
Publication Type: Germplasm Release
Publication Acceptance Date: 10/21/2003
Publication Date: 10/21/2003
Citation: Connor, E.E., Sonstegard, T.S., Ashwell, M.S., Matukamalli, L.K., Philpot, J.C., Shade, L.L., Bennett, G.L., Williams, J.L. 2003. Comparative mapping of a chromosomal region associated with a conformational trait locus in dairy cattle. Germplasm Release. Accession numbers. CG695835-CG699931, CG706319-CG706518, BV096721-BV096734.

Interpretive Summary: Germplasm release: No interpretive summary required.

Technical Abstract: The current gene density on the bovine maps is extremely limited and resolution of the human-bovine comparative map is insufficient for selection of candidate genes controlling many economic traits of interest in dairy cattle. Twelve selected gene-associated markers were positioned on the bovine linkage and radiation hybrid maps to improve the breakpoint resolution in the human-bovine comparative map near two previously identified quantitative trait loci for the conformation trait, dairy form. Two novel regions of conserved synteny were identified between the telomeric region of bovine chromosome 27 (BTA27) and human chromosome 3 (HSA3) p24 region and between the HSA4q34.1 region and BTA8. These data increase the number of genes positioned on the bovine gene maps, refine the human-bovine comparative map, and should improve the efficiency of candidate gene selection for the dairy form trait in cattle.