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Title: ISOLATION OF AN ADENOVIRUS AND AN ADENO-ASSOCIATED VIRUS FROM GOAT KIDS WITH ENTERITIS

Author
item OLSON, ERIK - UNIVERSITY OF MINNESOTA
item HASKELL, SCOTT - UNIVERSITY OF MINNESOTA
item FRANK, RODNEY - UNIVERSITY OF MINNESOTA
item LEHMKUHL, HOWARD
item HOBBS, LEA
item WARG, JANET - NVSL
item LANDGRAF, JOHN - NVSL
item WUNSCHMANN, ARNO - UNIVERSITY OF MINNESOTA

Submitted to: Journal of Veterinary Diagnostic Investigation
Publication Type: Peer Reviewed Journal
Publication Acceptance Date: 2/16/2004
Publication Date: 9/8/2004
Citation: Olson, E.J., Haskell, S.R., Frank, R.K., Lehmkuhl, H.D., Hobbs, L.A., Warg, J.V., Landgraf, J., Wunschmann, A. 2004. Isolation of an adenovirus and an adeno-associated virus from goat kids with enteritis. Journal of Veterinary Diagnostic Investigation. 16:461-464.

Interpretive Summary: Respiratory and enteric disease is a major cause of economic loss to the goat industry in the United States. Adenoviruses are known to produce both respiratory and enteric disease in goats. Adenovirus particles were detected in the pooled feces by electron microscopy from goat kids with diarrhea and pneumonia. This is the first report of enteritis in goats with an adenovirus antigenically related to ovine adenovirus type 2. This information is important for veterinary diagnosticians and if the virus is demonstrated to be widespread in the United States there may be a need to develop a vaccine.

Technical Abstract: A dairy goat operation in Minnesota experienced a sudden, markedly increased mortality among a subgroup of its neonatal goats (approximately 46%). The animals had diarrhea and dyspnea of one to two days duration prior to death. Necropsy of four goat kids revealed marked, acute, catarrhal enteritis and fibrinous pleuropneumonia. Basophilic inclusion bodies filling the entire nucleus were present in few enterocytes of the ileum of three goats. Adenovirus particles were detected in the pooled feces by electron microscopy and were subsequently isolated from the intestinal content together with a parvo-like virus (dependovirus). Morphology, physicochemical characteristics, and neutralization tests indicated that the adenovirus resembled ovine adenovirus-2 (OAdV-2). However, the restriction endonuclease pattern produced by the goat adenovirus was distinct from that of OAdV-2.