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ARS Home » Midwest Area » Ames, Iowa » National Animal Disease Center » Infectious Bacterial Diseases Research » Research » Publications at this Location » Publication #158715
Title: COMPARISON OF IMMUNOLOGIC RESPONSES OF BISON (BISON BISON) AND CATTLE TO VACCINATIONS WITH BRUCELLA ABORTUS STRAIN RB51

Author
item Olsen, Steven
item Stoffregen, William
item Waters, Wade

Submitted to: Research Workers in Animal Diseases Conference Proceedings
Publication Type: Proceedings
Publication Acceptance Date: 11/9/2003
Publication Date: 11/9/2003
Citation: Olsen, S.C., Stoffregen, W.C., Waters, W.R. 2003. Comparison of immunologic responses of bison (bison bison) and cattle to vaccinations with brucella abortus strain rb51 [abstract]. Proceedings of the 84th Annual Meeting of the Conference of Research Workers in Animal Diseases. Poster No. 67.

Interpretive Summary:

Technical Abstract: The prevalence of brucellosis in bison within Yellowstone National Park in the United States has raised concerns in regards to possible transmission to domestic livestock. The purpose of the study reported here was to characterize immunologic responses of bison and bovine calves to hand vaccination with Brucella abortus strain RB51 (SRB51), and to characterize responses to delivery of SRB51 in a biobullet. Immunologic responses evaluated included: antibody responses, proliferative responses to killed SRB51, g-interferon production (g-IFN), nitric oxide production, and flow cytometric analysis of proliferating PBMC subsets. Hand vaccinates tended to have greater antibody responses, proliferative responses and g-IFN tended to be greater in hand vaccinates as compared to ballistic vaccinates. Production of g-IFN peaked earlier in culture in vaccinated cattle as compared to bison. Our data suggests that immunologic responses of bison are similar to responses of cattle, although route of vaccine delivery can influence responses. Cumulative data suggests that vaccination of bison with SRB51 can reduce the incidence of abortion and risk of transmission, and may be of value as a management tool in an Brucella-infected bison herd.