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ARS Home » Midwest Area » Ames, Iowa » National Animal Disease Center » Virus and Prion Research » Research » Publications at this Location » Publication #160988
Title: A RECOMBINANT AD5 SWINE INFLUENZA VACCINE THAT OVERRIDES MATERNAL ANTIBODY INTERFERENCE

Author
item Wesley, Ronald
item Lager, Kelly

Submitted to: International Pig Veterinary Society (IPVS)
Publication Type: Proceedings
Publication Acceptance Date: 4/1/2004
Publication Date: 6/27/2004
Citation: Wesley, R.D., Lager, K.M. 2004. A recombinant Ad5 swine influenza vaccine that overrides maternal antibody interference. In: Proceedings of the 18th Congress of the International Pig Veterinary Society, Hamburg, Germany, June 27-July 2, 2004. p. 47.

Interpretive Summary:

Technical Abstract: Sows and gilts generally have some immunity to ubiquitous porcine adenoviruses but they lack immunity to human adenoviruses including the commonly used human adenovirus 5 (Ad5) serotype. Hence, critical immunogenic proteins of numerous swine pathogens can be expressed with Ad5 vectored vaccines in order to immunize suckling piglets that have acquired interfering, maternally-derived antibodies (1). These passively acquired antibodies are important for the early protection of piglets but are a common cause of vaccine failure. In this study we used a replication-incompetent Ad5 vaccine to prime immunity in one-week-old piglets. The piglets had suckled maternal antibodies from gilts with farm exposure to swine influenza virus (SIV). Three weeks later, the preconditioned piglets were vaccinated with a commercial SI vaccine yielding an anamnestic humoral immune response and solid protective immunity.