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ARS Home » Research » Publications at this Location » Publication #161236
Title: ANTICANCER AGENTS FROM UNIQUE NATURAL PRODUCTS SOURCES

Author
item IRELAND, CHRIS - UNIVERSITY OF UTAH
item ANDERSEN, RAYMOND - UNIV OF BRITISH COLUMBIA
item CLARDY, JON - HARVARD MEDICAL SCHOOL
item CHURCHILL, ALICE - BTI - CORNELL UNIVERSITY
item FROST, PHILIP - WYETH PHARMACEUTICALS
item Gibson, Donna
item GREENBERGER, LEE - WYETH PHARMACEUTICALS
item GREENSTEIN, MICHAEL - WYETH PHARMACEUTICALS

Submitted to: Pharmaceutical Biology
Publication Type: Peer Reviewed Journal
Publication Acceptance Date: 5/30/2004
Publication Date: 10/1/2004
Citation: Ireland, C.M., Andersen, R.J., Clardy, J., Churchill, A.C., Frost, P., Gibson, D.M., Greenberger, L., Greenstein, M. 2004. Anticancer agents from unique natural products sources. Pharmaceutical Biology. 41:S15-38.

Interpretive Summary: Anticancer Agents from Unique Natural Products Sources is a consortium of researchers from academia and industry organized in1995 in response to a request for proposals by the National Cancer Institute to establish National Cooperative Drug Discovery Groups (NCDDGs). The USDA-ARS participation in this consortium is founded on the use of isolates from the ARS Collection of Entomopathogenic Fungi, while our in house activities remain directed toward agricultural uses. The underlying theme of the overall program is to integrate the discovery of novel biologically active natural products from organisms that inhabit unique ecological niches with mechanism-directed biologically- based screening. The rationale behind this approach is that chemical diversity stems from biological diversity and environmental pressures that select for unique genotypes. This article summarizes the work of the consortium over the past 8 years and discusses a number of novel products discovered to date.

Technical Abstract: Anticancer Agents from Unique Natural Products Sources is a consortium of researchers from academia and industry organized in1995 in response to a request for proposals by the National Cancer Institute to establish National Cooperative Drug Discovery Groups (NCDDGs). The goal of the consortium is to discover and develop novel anticancer agents from a variety of natural product sources.