Author
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ORDOVAS, JOSE - TUFTS-HNRCA |
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Submitted to: Functional Foods for Health Promotion
Publication Type: Proceedings Publication Acceptance Date: 10/1/2002 Publication Date: 1/2/2003 Citation: ORDOVAS, J.M. INFLUENCE OF GENETICS ON RESPONSES TO DIETARY COMPONENTS: THE QUEST FOR PERSONALIZED RECOMMENDATIONS. FUNCTIONAL FOODS FOR HEALTH PROMOTION, 2003:36-39. Interpretive Summary: Technical Abstract: Both disease and longevity have a significant genetic component. For several decades we have struggled to determine the relative contribution of genes and the environment for most common disorders, such as cardiovascular diseases, diabetes, obesity, and cancer. We now have the tools to associate specific tags (genes) with disease traits. The swift development of genomics has taken us by surprise, so that we still apply the approaches used to characterize single-gene disorders to the resolution of common complex, polygenic disorders. Consequently, the field of polygenic disorders, most of them associated with aging, is filled with unsubstantiated and conflicting reports of genotype-phenotype associations, resulting in considerable disappointment and confusion in this area of research. It is now evident that a different and more comprehensive tactics is needed. The answer may come from new approaches that are characterized by buzzwords in the scientific and popular literature. Two of them are nutrigenomics and nutrigenetics. |
