Author
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ORDOVAS, JOSE - TUFTS-HNRCA |
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Submitted to: Human Genomics
Publication Type: Review Article Publication Acceptance Date: 10/19/2003 Publication Date: 1/1/2004 Citation: Ordovas, J.M. 2004. Pharmacogenetics of lipid diseases. Human Genomics 2004;1:111-125. Interpretive Summary: Technical Abstract: The genetic basis for most of the rare lipid monogenic disorders have been elucidated, but the challenge remains in determining the combination of genes that contribute to the genetic variability in lipid levels in the general population; this has been estimated to be in the range of 40'60 per cent of the total variability. Therefore, the effect of common polymorphisms on lipid phenotypes will be greatly modulated by gene'gene and gene'environment interactions. This approach can also be used to characterize the individuality of the response to lipid-lowering therapies, whether using drugs (pharmacogenetics) or dietary interventions (nutrigenetics). In this regard, multiple studies have already described significant interactions between candidate genes for lipid and drug metabolism that modulate therapeutic response, although the outcomes of these studies have been controversial, calling for more rigorous experimental design and analytical approaches. Once we have solid evidence about the predictive value of genetic panels, we can start generating risk and therapeutic algorithms that should provide an accurate measure of genetic predisposition, as well as targeted behavioral modifications or drugs of choice and also personalized dosage of these drugs. |
