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ARS Home » Northeast Area » Boston, Massachusetts » Jean Mayer Human Nutrition Research Center On Aging » Research » Publications at this Location » Publication #163501
Title: MODULATION OF ENDOTHELIAL CELL GENE EXPRESSION BY GREEN TEA EPIGALLOCATECHIN GALLATE (EGCG)

Author
item LIU, LIPING - TUFTS-HNRCA
item LAI, CHAOQIANG - TUFTS-HNRCA
item ORDOVAS, JOSE - TUFTS-HNRCA
item MOSER, LETA - TUFTS-HNRCA
item MEYDANI, MOHSEN - TUFTS-HNRCA

Submitted to: Experimental Biology
Publication Type: Abstract Only
Publication Acceptance Date: 2/1/2004
Publication Date: 3/24/2004
Citation: LIU, L., LAI, C., ORDOVAS, J.M., MOSER, L., MEYDANI, M. MODULATION OF ENDOTHELIAL CELL GENE EXPRESSION BY GREEN TEA EPIGALLOCATECHIN GALLATE (EGCG). EXPERIMENTAL BIOLOGY. 2004;18(4 PT I):A380.

Interpretive Summary:

Technical Abstract: Human and animal studies have shown that green tea consumption is associated with reduced risk of some cancer. This has been attributed to its polyphenols, in particular EGCG. EGCG inhibits angiogenesis, thus reduces tumor growth and metastasis. We tested the EGCG modulation of the endothelial cell's gene expression profile stimulated by VEGF using Affymetrix microarrays. We found that EGCG down-regulated 9 cell proliferation related genes, such as interacting protein of TATA binding protein, coactivator activator, and cyclin-A2. EGCG up-regulated the anti-proliferation genes such as mitogen-responsive phosphoprotein and IGF binding protein-7. EGCG also down regulated angiogenesis promoting genes, such as EGF response factor-2, sprouty homolog-2 and heme oxygenase-1. Further, EGCG modulated inflammatory genes of endothelial cells such as single Ig IL-1R-related molecule, and regulation of genes involved in glucose and cholesterol metabolism. Thus, we hypothesize that the anti-angiogenesis effect of EGCG was partially mediated through up-regulation of genes such as antagonist of FGF signaling and tryptophanyl-tRNA synthetase, and down regulation of angiogenesis promoting genes. Our data further supports earlier observations in anticancer effect of EGCG through modulation of genes associated with angiogenesis and cell proliferation.