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ARS Home » Northeast Area » Boston, Massachusetts » Jean Mayer Human Nutrition Research Center On Aging » Research » Publications at this Location » Publication #164746
Title: FUNCTION OF THE UBIQUITIN PROTEOLYTIC PATHWAY IN THE EYE

Author
item SHANG, FU - TUFTS-HNRCA
item TAYLOR, ALLEN - TUFTS-HNRCA

Submitted to: Experimental Eye Research
Publication Type: Review Article
Publication Acceptance Date: 10/1/2003
Publication Date: 1/4/2004
Citation: Shang, F., Taylor, A. 2004. Function of the ubiquitin proteolytic pathway in the eye. Experimental Eye Research. 78:1-14.

Interpretive Summary:

Technical Abstract: Compelling reasons to study the function of the ubiquitin pathway (UP) include several major recent observations: 1) a fully functional UP has been documented in the lens, retina, and cornea, 2) the UP is involved in regulation of cell proliferation and differentiation in eye tissues, and 3) there is an accumulation of damaged proteins, including ubiquitinated proteins, in the lens and retina upon aging or exposure to stress. Thus, an active UP may be required to avoid such age and disease-related accumulation of damaged proteins. In this review we will explain the biochemistry of the UP and we will document the most important studies regarding UP function in the lens, retina and cornea.