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ARS Home » Plains Area » College Station, Texas » Southern Plains Agricultural Research Center » Food and Feed Safety Research » Research » Publications at this Location » Publication #166523
Title: SWAINSONINE COMPOUNDS AS INHIBITORS OF TOXIN RECEPTOR EXPRESSION

Author
item Anderson, Robin
item Droleskey, Robert - Bob
item Nisbet, David

Submitted to: Patent Application
Publication Type: Patent Application
Publication Acceptance Date: 6/11/2002
Publication Date: 12/30/2003
Citation: Anderson, R.C., Droleskey, R.E., Nisbet, D.J. 2003. Swainsonine compounds as inhibitors of toxin receptor expression. U.S. Patent 6,670,374B1.

Interpretive Summary:

Technical Abstract: This invention provides a method for treating infections in animals which are caused by toxin producing enteric bacterial pathogens, including Shigella species, enterohemorrhagic E. coli, and enterotoxigenic E. coli. Receptors expressed by animal cells which typically recognize these bacterial toxins may be modified by administration of swainsonine compounds to the animal, thereby effectively inhibiting toxin binding to the cells.