Skip to main content
ARS Home » Northeast Area » Boston, Massachusetts » Jean Mayer Human Nutrition Research Center On Aging » Research » Publications at this Location » Publication #166807
Title: THE STATE VERSUS AMYLOID-BETA: THE TRAIL OF THE MOST WANTED CRIMINAL IN ALZHEIMER'S DISEASE

Author
item ROTTKAMP, CATHERINE - CASE WESTERN RESERVE UNIV
item ATWOOD, CRAIG - CASE WESTERN RESERVE UNIV
item Joseph, James
item AKIHIKO, NUNOMURA - ASAHIKAWA MEDICAL COLLEGE
item PERRY, GEORGE - CASE WESTERN RESERVE UNIV
item SMITH, MARK - CASE WESTERN RESERVE UNIV

Submitted to: Peptides
Publication Type: Review Article
Publication Acceptance Date: 6/13/2001
Publication Date: 7/1/2002
Citation: Rottkamp, C.A., Atwood, C.S., Joseph, J.A., Akihiko, N., Perry, G., Smith, M.A. 2002. The state versus amyloid-beta: the trail of the most wanted criminal in alzheimer's disease. Peptides 23 (2002) 1333-1341.

Interpretive Summary: Investigators studying the primary culprit responsible for Alzheimer disease have, for the past two decades, primarily focused on amyloid-beta(Abeta). Abeta is a protein deposit seen in abundance in the brains of Alzheimer disease patients. Here, we put Abeta on trial and review evidence amassed by the prosecution that implicate Abeta and also consider arguments and evidence gathered by the defense team who are convinved of the innocence of their client. As in all trials, the arguments provided by the prosecution and defense revolve around the same evidence, with opposing interpretations. Below, we present a brief synopsis of the trail for you, the jury, to decide the verdict. Amyloid-beta: guilty or not-guilty?

Technical Abstract: Investigators studying the primary culprit responsible for Alzheimer disease have, for the past two decades, primarily focused on amyloid-beta (Abeta). Here, we put Abeta on trial and review evidence missed by the prosecution that implicate Abeta and also consider arguments and evidence gathered by the defense team who are convinced of the innocence of thier client. As in all trials, the arguments provided by the prosecution and defense revolve around the same evidence, with opposing interpretations. Below, we present a brief synopsis of the trial for you, the jury, to decide the verdict. Amyloid-beta: guilty or not-guilty?