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Title: FVABC1, A FUSARIUM VERTICILLIOIDES GENE ENCODING AN ATP-BINDING CASSETTE PROTEIN, MAY BE REQUIRED FOR TOLERANCE OF PHYTOANTICIPINS PRODUCED BY CORN (ZEA MAYS)

Author
item PALENCIA, E - PLANT PATH/U GEORGIA
item Glenn, Anthony - Tony

Submitted to: Phytopathology
Publication Type: Abstract Only
Publication Acceptance Date: 6/1/2004
Publication Date: 7/15/2004
Citation: Palencia, E.R., Glenn, A.E. 2004. Fvabc1, a fusarium verticillioides gene encoding an atp-binding cassette protein, may be required for tolerance of phytoanticipins produced by corn (zea mays). Phytopathology. 94:S80.

Interpretive Summary: American Phytopathological Society abstract - no summary required

Technical Abstract: The ascomycete Fusarium verticillioides, a common pathogen of corn (Zea mays) throughout the world, often causes significant concern due to production of mycotoxins such as fumonisins. Corn produces the phytoanticipins 6-methoxy-2-benzoxazolinone (MBOA) and 2-benzoxazolinone (BOA) as a general chemical defense mechanism, yet F. verticillioides can actively metabolize these compounds. The present study was initiated to characterize an ATP-binding-cassette (ABC) transporter gene which may be required for tolerance of both MBOA and BOA. ESTs, having homology to fungal ABC transporters, were previously identified in a subtracted cDNA library enriched for genes expressed in response to BOA. We have sequenced a putative ABC transporter gene (FvABC1) from a genomic cosmid clone. Characterization of FvABC1 is underway, including creation of a gene knock-out mutant. Future plans include assessing the role of this ABC-transporter gene in F. verticillioides tolerance to antimicrobial compounds and whether such tolerance impacts in planta associations with corn or the ecological fitness of F. verticillioides in general.