Skip to main content
ARS Home » Midwest Area » Ames, Iowa » National Animal Disease Center » Ruminant Diseases and Immunology Research » Research » Publications at this Location » Publication #169864
Title: INTERLEUKIN-8 EXPRESSION IN MAMMARY GLAND TISSUE INFECTED WITH ESCHERICHIA COLI

Author
item KRUEGER, REBECCA - UNIVERSITY OF WISCONSIN
item MCCLENAHAN, DAVID - UNIVERSITY OF WISCONSIN
item Kehrli Jr, Marcus
item CZUPRYNSKI, CHARLES - UNIVERSITY OF WISCONSIN

Submitted to: Conference Research Workers Disease Meeting
Publication Type: Abstract Only
Publication Acceptance Date: 10/1/2004
Publication Date: 11/14/2004
Citation: Krueger, R., McClenahan, D., Kehrli Jr., M.E., Czuprynski, C. 2004. Interleukin-8 expression in mammary gland tissue infected with Escherichia coli [abstract]. Conference of Research Workers in Animal Diseases. Paper No. P45. p. 94.

Interpretive Summary:

Technical Abstract: Epithelial and endothelial cells play a pivotal role in initiating and controlling the movement of cells into tissues during inflammation.Ê One example of epithelial and endothelial involvement in inflammation is neutrophil migration into bovine mammary tissue during the initial stages of Escherichia coli (E. coli) mastitis.Ê The central hypothesis was that activated epithelial and endothelial cells produce IL-8 during tissue inflammation.Ê The specific objective of this study was to use in situ hybridization with an IL-8 riboprobe to determine IL-8 expression by mammary gland epithelial and endothelial cells in response to experimental infection with E. coli.Ê The results to date have shown that IL-8 is an early contributor in the inflammation process.