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Title: INHIBITORY EFFECTS OF ERINACOL ON PROLIFERATION OF VASCULAR SMOOTH MUSCLE CELLS AND ITS PROTECTIVE EFFECT ON CC1 4-INDUCED HEPATIC DAMAGE

Author
item CHOI, WON-SIK - SOONCHUNHYANG UNIV, KOREA
item KIM, CHANG-JIN - SOONCHUNHYANG UNIV, KOREA
item PARK, BYEOUNG-SOO - SEOUL NAT'L UNIV, KOREA
item LEE, SUNG-EUN - SEOUL NAT'L UNIV, KOREA
item Takeoka, Gary
item KIM, DONG-GOO - H&M BIO CO., LTD., KOREA
item LANPIAO, XIANG - SEOUL NAT'L UNIV, KOREA
item KIM, JEONG-HAN - SEOUL NAT'L UNIV, KOREA

Submitted to: Journal of Ethnopharmacology
Publication Type: Peer Reviewed Journal
Publication Acceptance Date: 2/17/2005
Publication Date: 6/6/2005
Citation: Choi, W-S., Kim, C-J., Park, B-S., Lee, S-E., Takeoka, G.R., Kim, D-G., Lanpiao, X., Kim, J-H. 2005. Inhibitory effect on proliferation of vascular smooth muscle cells and protective effect on CC1 4-induced hepatic damage of HEAI extract. Journal of Ethnopharmacology. 100:176-179.

Interpretive Summary: Smooth muscle cells are one of the main cellular components of the walls of blood vessels and they play an important role in vascular pathology. Smooth muscle cell proliferation is a major factor in the development of several vascular diseases including atherosclerosis. Agents that inhibit vascular smooth muscle cell proliferation may be useful in treating diseases such as atherosclerosis. Hericum erinaceum is a well known traditional edible mushroom that is also known as lion's mane. Our study found that Erinacol, a methanol extract of Hericium erinaceus cultivated with Artemisia iwayomogi, inhibited human vascular smooth muscle cell proliferation. Erinacol also had a strong protective effect on the livers of rats exposed to chemicals such as carbon tetrachloride.

Technical Abstract: The effects of methanol extract from Hericium erinaceus cultivated with Artemisia iwayomogi (Erinacol) on proliferation of vascular smooth muscle cells and carbon tetrachloride-induced hepatic damage were evaluated. Erinacol was shown to have a potent inhibitory effect on the proliferation of vascular smooth muscle cells (VSMCs). Interestingly, a methanol extract of Hericium erinaceus showed no inhibitory effect on the proliferation of VSMCs, while a methanol extract of Artemisia iwayomogi possessed strong inhibitory effects on the proliferation of VSMCs. Therefore, the inhibitory effects of Erinacol may be caused by the changes of chemical components in the culture broth after the addition of Artemisia iwayomogi in the Erinacol growth media. Erinacol also had a strong protective effect on carbon tetrachloride-induced hepatic damage in rats. The activity was evaluated using biochemical parameters such as glutamic oxaloacetic transaminase (GOT), glutamic pyruvic transaminase (GPT) and alkaline phosphatase (ALP). Erinacol treatment caused a significant reduction in the activity of GOT but not of GPT and ALP in comparison with those only receiving carbon tetrachloride treatment. Histopathological studies showed that liver samples treated with Erinacol were significantly different when compared to non-treated animals after carbon tetrachloride exposure.