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Submitted to: Meeting Abstract
Publication Type: Abstract Only Publication Acceptance Date: 12/15/2004 Publication Date: 4/2/2005 Citation: Park, J.B. 2005. N-coumaroyldopamine and its analogues found in cocoa (theobroma cacao l.) are potent beta-adrenoceptor agonists suppressing platelet activition via increasing camp production. [Abstract]. Experimental Biology 566(2): 566. Interpretive Summary: No Interpretive Summary is required for a meeting abstract. Technical Abstract: N-coumaroyldopamine and its natural analogues (N-cinnamoyldopamine, N-caffeoyldopamine, N-feruloyldopamine and N-sinapoyldopamine) are clovamide-type phenylpropenic acid amides that have chemical structures similar to beta adrenoceptor agonists such as dobutamine and denopamine used for treating cardiac decompression. Beta-adrenoceptor agonists have been used clinically for treating symptoms originating from cardiac diseases. N-coumaroyldopamine and its analogues are phytochemicals found in various plants including cocoa (Theobroma cacao L.). In this study, N-coumaroyldopamine and its natural analogues were synthesized and investigated to determine their potency as beta-adrenoceptor agonists. These phytochemicals increased cAMP production via beta 2-adrenoceptors in monocytic U937 cells and platelets. Platelet aggregation is a main cause of human heart disease, which can be inhibited by increasing cAMP production in platelets. Therefore, the effects of N-coumaroyldopamine and its analogues on platelet aggregation were investigated in in vitro and in vivo models. This study provides information regarding the efficacy of N-coumaroyldopamine and its analogues as beta-adrenoceptor agonists and their effects on platelet aggregation in vitro and in vivo. |
