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ARS Home » Northeast Area » Boston, Massachusetts » Jean Mayer Human Nutrition Research Center On Aging » Research » Publications at this Location » Publication #171873
Title: THE STATE VERSUS AMYLOID-BETA: THE TRAIL OF THE MOST WANTED CRIMINAL IN ALZHEIMER'S DISEASE

Author
item ROOTKAMP, CATHERINE - CASE WESTERN RESRV UNIV
item ATWOOD, CRAIG - CASE WESTERN RESRV UNIV
item Joseph, James
item AKIHIKO, NUNOMURA - ASAHIKAWA MEDICAL COLLEGE
item PERRY, GEORGE - CASE WESTERN RESRV UNIV
item SMITH, MARK - CASE WESTERN RESRV UNIV

Submitted to: Peptides
Publication Type: Review Article
Publication Acceptance Date: 6/13/2001
Publication Date: 5/28/2002
Citation: Rottkamp, C.A., Atwood, C.S., Joseph, J.A., Akihiko, N., Perry, G., and Smith, M.A. 2002. The State versus amyloid-beta: The trail of the most wanted criminal in Alzheimer's Disease. Peptides 23: 1333-1341.

Interpretive Summary: Investigators studying the primary culprit responsible for Alzheimer disease have, for the past two decades, primarily focused on amyloid-beta (Abeta). Abeta is a protein deposit seen in abundance in the brains of Alzheimer disease patients. Here, we put Abeta on trial and review evidence amassed by the prosecution that implicate Abeta and also consider arguments and evidence gathered by the defense team who are convinced of the innocence of their client. As in all trials, the arguments provided by the prosecution and defense revolve around the same evidence, with opposing interpretations. Below, we present a brief synopsis of the trial for you, the jury, to decide the verdict. Amyloid-beta: guilty or not-guilty?

Technical Abstract: Investigators studying the primary culprit responsible for Alzheimer disease have, for the past two decades, primarily focused on amyloid-beta (Abeta). Here, we put Abeta on trial and review evidence amassed by the prosecution that implicate Abeta and also consider arguments and evidence gathered by the defense team who are convinced of the innocence of their client. As in all trials, the arguments provided by the prosecution and defense revolve around the same evidence, with opposing interpretations. Below, we present a brief synopsis of the trial for you, the jury, to decide the verdict. Amyloid-beta: guilty or not-guilty?