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Title: PHYLOGENETIC ANALYSIS OF CLASSICAL SWINE FEVER VIRUS (CSFV) FIELD STRAINS ISOLATED IN CENTRAL AND SOUTH AMERICA

Author
item PEREDA, A.J. - IN.DE BIOTECNOLOGIA ARG A
item GREISER-WILKE, I. - IN.OF VIROLOGY, GERMANY
item SCHMITT, B. - USDA/APHIS, NVL, AMES
item RINCON, M.A. - IN.COLOMBIANO AGROPEC.
item MOGOLLON, J.D. - IN.COLOMBIANO AGROPE.
item SABOGAL, Z.Y. - IN.COLOMBIANO AGROPE.
item LORA, A.M. - IN.COLOMBIANO AGROPE.
item SANGUINETTI, H. - SENASA, ARGENTINA
item Piccone, Maria

Submitted to: Virus Research
Publication Type: Peer Reviewed Journal
Publication Acceptance Date: 12/20/2004
Publication Date: 6/1/2005
Citation: Pereda, A., Greiser-Wilke, I., Schmitt, B., Rincon, M., Mogollon, J., Sabogal, Z., Lora, A., Sanguinetti, H., Piccone, M.E. 2005. Phylogenetic Analysis of Classical Swine Fever Virus (CSFV) Field Strains Isolated in Central and South America. Virus Research. 110: (1-2) P. 111-118

Interpretive Summary: Classical Swine Fever (CSF), or hog cholera, is a highly contagious viral disease of pigs. An outbreak of CSF results in the immediate loss of export markets for all pork and pork products, and outbreaks are associated with high economic and welfare consequences. Molecular epidemiology based on nucleotide sequence diversity is a useful tool for tracing virus spread and for developing disease control strategies. In this paper we have determined the relatedness between South and Central American CSFV isolates from 1978 to 2002. The results showed that all the strains analyzed belonged to group 1 and represents a progress towards identifying the extent and distribution of CSF virus diversity in the region.

Technical Abstract: Up to date, there exists little information concerning the epidemiological situation of classical swine fever (CSF) in the Americas. In the present communication, available data are summarized. In addition, a 190 base pair fragment of the E2 envelope glycoprotein gene of available classical swine fever viruses (CSFV) isolated from domestic pigs in different South and Central American countries was used for genotyping. It was found that all the strains analyzed belonged to group 1 and were further resolved into three subgroups. The Cuban isolates clustered in subgroup 1.2, whereas the isolates from Honduras and Guatemala clustered in subgroup 1.3. The remaining isolates from Argentina, Brazil, Colombia and Mexico generated relatively distinct clusters in subgroup 1.1. The results reveal the genetic diversity of CSFV in South America and could be used for the establishment of a regional database, which is essential for helping South American epidemiologists to trace the virus spread and in the development of appropriate control and eradication programs. This will be pursued in the scope of the Continental Plan for Classical Swine Fever Eradication in the Americas (FAO program TCP/ARG/2901).