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Title: RECOMBINANT SCFV ANTIBODIES SPECIFIC TO EIMERIA SPP. RESPONSIBLE FOR COCCIDIOSIS

Author
item KIM, J - SEOUL KOREA
item HAN, JAE - SEOUL KOREA
item SONG, K - KOREA
item KIM, S - KOREA
item Min, Wongi
item SON, EUN - USDA,ARS,ANRI,APDL
item Lillehoj, Hyun
item LILLEHOJ, PETER - U MD BALTIMORE

Submitted to: Patent Application
Publication Type: Other
Publication Acceptance Date: 4/5/2005
Publication Date: 4/15/2007
Citation: Kim, J.K., Han, J.Y., Song, K.D., Kim, S.W., Min, W., Son, E.J., Lillehoj, H.S., Lillehoj, P. 2007. Recombinant scfv antibodies specific to eimeria spp. responsible for coccidiosis. Patent Application 6790937.

Interpretive Summary: Avian coccidiosis is caused by several different Eimeria species which infect the gut of chickens. Infection with these parasites cause severe damage to the gut and, as a result, chickens do not gain body weight normally. In this US Patent, ARS scientists in collaboration with scientists at Seoul National University and Changwon University, developed recombinant antibody fragment which recognize important structural protein of Eimeria. Using this recombinant antibody, the scientists are now trying to develop an intervention strategy to reduce coccidiosis infection in the field. Preliminary results described in this patent indicate a possibility of reducing coccidiosis using this recombinant protein. The results will help US industry to develop novel control methods for avian coccidiosis. interferes with nutrient absorption. The present invention relates to (a) variable regions of heavy and light chains of an antibody specific to a surface antigen in sporozoite of Eimeria spp.; (b) a recombinant ScFv (single chain variable fragment ) antibody prepared using the variable region; (c) a method for preparing a recombinant ScFv antibody; and (d) an expression vector for expression a recombinant ScFv antibody.

Technical Abstract: The present invention relates to (a) variable regions of heavy and light chains of an antibody specific to a surface antigen in sporozoite of Eimeria spp.; (b) a recombinant ScFv (single chain variable fragment ) antibody prepared using the variable region; (c) a method for preparing a recombinant ScFv antibody; and (d) an expression vector for expression a recombinant ScFv antibody.